<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27318

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDAKQKEDELTALNVKQGFNNQPAVSADEHGSAKNVNFNPAKISSNFSSIMSEKLRCNTLPDTGRRKPQVNQKDNFMLVTVRTQSSINTWFSDLAGTKPLTHLAKKVSHMFNRFVHIEENLGNIIPSVLPLVQPLCILKNFQNFPCSHFPLIFLIWVIKGHVDLCAEWTQIITRYLWEQLQKIADYYRPALGGCSSPSGPMPPEVEVALKQWEYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRQGEDELLKLLLPLLLRYSNSLVQSAYLSRRLAYFCTRRLAQLLEGSGSHPGHLMTAQTGTALPPAPAPPPPSGSAPSSPFSDLLQCPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDNRIKTGSPLDHLPIAPSSLPMPGGSSAFTQQVRRKLRDMEQQIKERGRSVEVRWSFDKCQEATAGFPIGRVLHTLEVLDSHSFEKSDFSNNLDSLYNRIFGLGLGKDGHEISPDDDAVVTLLCEWAVSCKRYGHHRALVVAKLLEKRQAEIEAERCGDSEAVDEKGSVSSGSLSALSAPPVFQEVLLQFLDTQAPMLTDPANESERVEFYNLVLLFCELIRHDVFSHNMYMCTLISRGDLGIDPHAPRPRSPYEDPSDDTDRKEGEANSSIKLEDTTLSETMDIDHGSGALFEDMEKSEFPMFSPAMRCEGRSPGPEDGDRDIRRTVKGLNGEGPLSALYDQPRHIQYATHFPIPQEESCSHECNQRLVVLYGVGRQRDDARHIIKRITRDILKVLNRKSTSETGKIEKQVNVPKLTLSPCGTDEGQRRRRAKPEAFPTAEEIFCRFQQLSHFDQHQVTAQVSRNVLEQITSFALGLSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSSLVGSYTMGLCLCIVAVLRHYHTCLILNQEQTAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEQEFMLDTIINPSGHSVNCGMLGKLLSDSPTNRYSFVCNALVHVCAGDHDTDRVNDIAILCAELTGSCKALSSEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILVARQCLLLEDLIRCAAIPSLLNAACSEQDSEAGARLTCRILLHLFKTPQLNPCEPDGSKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELRGSGFSHPTGTDNASEEDIATRRAGGRPVSIETASLDEYAKYVLRSICQQEWVGERCVRSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLNDTEQGDNPQRQRIKHILQNLDQWTMRQSALELQLMIKQTPSNEMNSLLENIAKATIEVFQQSAENACAAPANSAALSNATSSNAPPNSKTKPVLSSLERSGAWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYGQVQQIVSNWREDQYQDDCKTPQLLHDVLKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGIKQSAPLSWGWFGTVRVDRRVSRMEEQQRLLLYHTHLKPKPRSYYLENLPLPPEDEEPPTPTSTEPDKKLSEALKVDKSGVGGTTNTDDRKKPSKPKREKKRNMAPSKVEEFPLGPGRPGPYGMVPTDLLHTQAAGMSRLPYATQNMYAQNQPLPPGGPRLDNSYRPTRMAMVKVPARPQYVSGVPQAGMMDSYKPVMYRPQPPIPQGQLLRQQLQAKLAQGMMPQPVRQMSQTPSYGSMQPQGYTSYGSHMTLQQHPPPSQAGALVPPPYSTQQYPGSLPPSGGALLDPVRQMQQRPSGYVHQQASGFSHSASAGQRFPHQQITQTGMMPSMGHLTTQPVTGAIRPQLLPERQQQILRVRAPPQPPPQQVPTVPQPQTQGQPPGLGMQTLQVSVGVGSVLSVSTEWRYLHELLNFTGDFIPIGFLSFLTDKSLSQFQRQGLQQTQQQQQTAALVRQLQQQLSSTQPQQNSNPFGRY
Length2178
PositionKinase
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
Lineage
Aromaticity0.07
Grand average of hydropathy-0.388
Instability index51.20
Isoelectric point6.66
Molecular weight242433.56
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27318
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     579.91|     143|     162|    1846|    2006|       1
---------------------------------------------------------------------------
 1716- 1774 (69.96/29.33)	VRVDRR.....VS.....RMEEQQRLLLYHTHlKPKPR.........................................................................................................................................syYLENLPLPPED..........eePPTPTSTEPDKklSEA
 1775- 1873 (167.89/82.24)	LKVD....K...SGVGGTTNTDD......RKK.PSKPKRE......................KKRNM..................APSKVEEFPLGPGRPGPYGMVPTDLLHTQAAGMSRLPYATQ...............................................NM..YAQNQPLPPGG............PRLDNSYRPTR..MAM
 1874- 2060 (232.99/143.36)	VKVPAR..PQYVSGVPQAGMMDSYKPVMYRPQ.PPIPQGQLLRQQLQAKLAQG..M.MPQPVRQMSQ..................TPSYGSMQPQGYTSYGSHMTLQQHPPPSQAGALVPPPYSTQqypgslppsggalldpvRQMQQRPSGYVHQQasgfshsasagqrfphQQ..ITQTGMMPSMGhlttqpvtgairPQL.LPERQQQ..ILR
 2061- 2170 (109.08/50.25)	VRAPPQppPQQVPTVPQ........P.QTQGQ.PP....GLGMQTLQVSVGVGsvLsVSTEWRYLHEllnftgdfipigflsfltDKSLSQFQRQG.........LQQTQQQQQTAALV........................RQLQQQLSSTQPQQ...........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.00|      51|      77|     283|     334|       2
---------------------------------------------------------------------------
  283-  334 (83.61/46.40)	PLLLRYSnSLVQSAYLSRRLAYFCTRRLAQLLEGSGSHPGHLMTAQTGTALP
  362-  412 (94.39/49.05)	PLVFGLS.CMLQSIVLCCPSALVWHYSLTDNRIKTGSPLDHLPIAPSSLPMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.36|      10|      77|     179|     193|       3
---------------------------------------------------------------------------
  179-  193 (14.82/22.14)	FLIWVIKghvdlCAE
  259-  268 (21.55/13.14)	FLTWVLE.....CFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.00|      19|      77|    1330|    1354|       4
---------------------------------------------------------------------------
 1330- 1348 (32.91/11.90)	LNDTEQGDNPQRQRIKHIL
 1523- 1541 (34.10/25.91)	REDQYQDDCKTPQLLHDVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.31|      32|     162|     555|     594|       6
---------------------------------------------------------------------------
  555-  594 (42.68/48.00)	KGSVSSGSLSALSAPPVFqevlLQFlDTQAPMltdPANES
  718-  749 (61.63/40.46)	KGLNGEGPLSALYDQPRH....IQY.ATHFPI...PQEES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.49|      23|     550|     939|     961|      13
---------------------------------------------------------------------------
  939-  961 (41.04/26.87)	TCLILNQEQTAQVFEGLCGVVKH
 1495- 1517 (40.45/26.37)	TCLKGQDEQREGLLTSLYGQVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.57|      11|     111|    1006|    1016|      24
---------------------------------------------------------------------------
 1006- 1016 (22.58/15.82)	NTIYCNVEPSD
 1115- 1125 (20.99/14.10)	NDLLCNVDVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.24|      21|      23|    1560|    1582|      28
---------------------------------------------------------------------------
 1560- 1582 (30.70/24.92)	QQTTewAVL.LLDIISSGTV..DMQS
 1585- 1608 (26.54/13.79)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27318 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSYKPVMYRPQPPIPQGQLLRQQLQAKLAQGMMPQPVRQMSQTPSYGSMQPQGYTSYGSHMTLQQHPPPSQAGALVPPPYSTQQYPGSLPPSGGALLDPVRQMQQRPSGYVHQQASGFSHSASAGQRFPHQQITQTGMMPSMGHLTTQPVTGAIRPQLL
2) ERQQQILRVRAPPQPPPQQVPTVPQPQTQGQPPGLGMQ
3) FSPAMRCEGRSPGPEDGDRDIRRTVKGLNGEGPLSALYDQPRHIQYATHFPIPQE
4) GIDPHAPRPRSPYEDPSDDTDRKEGEANSSIKLEDTTLSE
5) SYYLENLPLPPEDEEPPTPTSTEPDKKLSEALKVDKSGVGGTTNTDDRKKPSKPKREKKRNMAPSKVEEFPLGPGRPGPYGMVPTDLLHTQAAGMSRLPYATQNMYAQNQPLPPGGPRLDNSYRPTRMAMVKVPARPQYVSGVPQ
1893
2053
693
631
1744
2051
2090
747
670
1888










Molecular Recognition Features






MoRF SequenceStartStop




1) YKPVMYR
1895
1901