<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27315

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVTGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPATGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTTTPQTQLQLQQVALQQQQQFQQQQVALQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQLQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPTVAQNQPSQLPPQSQTQPLVSQAPPLPGQMMYTQQQLKLVRPPMVVQQPQVQPQVQQQQTAVPTAQASQIVGSGVQMITAALAQGGMQVRARFPPTTAMSAVPSSSISLGGQPLAQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPVTAPVVCARKRKFEEDEKQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length782
PositionTail
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.03
Grand average of hydropathy-0.685
Instability index85.71
Isoelectric point9.46
Molecular weight85911.64
Publications
PubMed=19892987

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27315
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.77|      19|      27|     296|     322|       4
---------------------------------------------------------------------------
  296-  322 (27.63/15.24)	PPQPQqPtvaqnQPSQlpPQSQTQPLV
  445-  463 (36.15/ 6.74)	PPQPS.P.....QPGQ..PSSQPNSNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.83|      20|      22|      95|     116|       5
---------------------------------------------------------------------------
   86-  105 (37.95/17.52)	QSLTGGPATGAAGIGMPSRG
  108-  127 (40.88/27.71)	QSLGGMGGLGAMGQPMPLSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.43|      15|      22|     221|     235|       6
---------------------------------------------------------------------------
  221-  235 (29.30/ 6.59)	QNQQQLQQQQQQLQR
  242-  256 (30.13/ 6.99)	QQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.07|      33|      36|     464|     496|       7
---------------------------------------------------------------------------
  362-  422 (34.08/ 8.13)	TA....................VPTaqasqivgsgvqmitaalaqggmqvrarfPPTTAMSAVPSSSISLGGQPL.AQVSQN
  442-  494 (48.21/14.91)	MPpppqpspqpgqpssqpnsnvSSG.............................PAPSPSSFLPSPSPQPSQSPVTARTPQN
  593-  622 (51.78/16.62)	MA....................VPT.............................PPPPP..V.PPTKQQYLCQPLLDAVLAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.79|      29|     201|     129|     157|       9
---------------------------------------------------------------------------
  129-  157 (54.63/21.25)	PP.PGTSGMAPHGMAVVSTT....TPQTQLQLQQ
  326-  359 (47.16/17.24)	PPlPGQMMYTQQQLKLVRPPmvvqQPQVQPQVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.45|      30|     151|     542|     576|      11
---------------------------------------------------------------------------
  542-  576 (44.06/38.35)	RMINKIDkneDrkKDLSKMKSL.LDILTDPSKRCPL
  699-  729 (49.39/28.60)	HLICKLD...D..KDLPSVPPLeLSVPADYPAQSPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27315 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NALQSLTGGPATGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTTT
2) QQVALQQQQQQQQQFQAQQNAMQQQFQAVV
3) VLGALQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPTVAQNQPSQLPPQSQTQPLVSQAPPLPGQMMYTQQQLKLVRPPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQMITAALAQGGMQVRARFPPTTAMSAVPSSSISLGGQPLAQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNGGACLVFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
85
171
228
150
200
513










Molecular Recognition Features






MoRF SequenceStartStop




NANANA