<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27311

Description Mediator complex subunit 12 like
SequenceQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHVASSAGEGPVPVPPDVEQAMKQWEYNEKLAFHLFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLAAHSPHMMIGPSSSSIGAPSPGAPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDSKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWAHQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSEYEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTQPRSPAGDNADEHYPKDHDGSRKSGLVKPGFSQSMDGSPSSQEMFESQTLPSCSLFSPSLPCSAGHSPSPNTPPVEEELPPPGQEPFRGVLGVEVNQPRTVQYLSHLQPIPKDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSSTETGVLKHIVPNTTGDKTWVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVANPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSVLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGKAILALSFTVKSGTHFFAVRRNGKGTSRRSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECPEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQASVAEMNNLLDNIAKATIEVFQQSADLNNNSSMCANRKDASLGVTPVSDFSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDTKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGDGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPSSPVSQEPERKSAE
Length1742
PositionKinase
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.07
Grand average of hydropathy-0.277
Instability index52.32
Isoelectric point6.41
Molecular weight193903.21
Publications
PubMed=19892987

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27311
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     290.50|      86|     155|     887|    1000|       1
---------------------------------------------------------------------------
  891-  957 (102.65/63.96)	....................LCVCIVAVLrRY...........................HSCL..ILNPDQTAQVFEGLCGVVKHVANPSECSSPERCILAYLYDLYVSCSHLRSK
  958- 1060 (102.98/98.68)	FGDLFSSACSKVKQTIYNNV............mpansnlrwdpdfmmdfienpsarsinYSVLgkILS.DNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSE
 1062- 1122 (84.88/48.62)	LGVLKALCCSSNHVWGFNDVLCTVDVSDL.SF...........................HDSLatFIAILIARQCF.SLEDVVQHVALPS..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.65|      40|     156|    1281|    1331|       2
---------------------------------------------------------------------------
 1281- 1331 (58.55/67.13)	LSNMQAQKLLQLI..CYpHGIKECPEG..DNLQRQhIKRILQNleqwtlrqsWLE
 1444- 1487 (63.10/40.60)	MSLLSQQPFLSLVltCL.KGQDEQREGllTSLQNQ.VNQILSN.........WRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.59|      41|      56|     732|     772|      15
---------------------------------------------------------------------------
  732-  772 (66.74/56.22)	KERDEARHQLKKI.TK.DILKILNKK...SSTETGVLKHIVPNTTG
  786-  831 (53.85/43.58)	KSKQEAFPTLETVfTKlQLLSYFDQHqvtSQISNNVLEQITSFASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.62|      28|    1047|     661|     688|      23
---------------------------------------------------------------------------
  661-  688 (59.14/36.73)	PCSAGHSPSPNTPPVEEELP..PPGQEPFR
 1709- 1738 (50.48/30.11)	PRSYYLEPLPLPPEEEEEEPssPVSQEPER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27311 with Med12 domain of Kingdom Metazoa
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