<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27297
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICFPSPGPGLVWVLCGWQPLPGRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLCGGLWWRVPLSYP |
Length | 860 |
Position | Tail |
Organism | Callithrix jacchus (White-tufted-ear marmoset) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae>
Callitrichinae> Callithrix> Callithrix.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.052 |
Instability index | 49.23 |
Isoelectric point | 7.88 |
Molecular weight | 95097.56 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
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GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
|
GO - Biological Function | catalytic activity GO:0003824 IEA:InterPro
thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP27297
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 325.68| 98| 369| 378| 493| 1
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195- 286 (134.54/79.67) PS.GQVLTSTESLCRLRGRVALADIA..FTGGGNIVV...ATADGSSASP.VQFYKVCVSVVS.....EKCRIDTEILP.....SLfMRCTTDLNRKDKFP.AITHLKFL.....
378- 482 (150.72/131.13) PGlGLALAFHDGSVHIVHRLSLQTMAvfYSSAAPRPVdepAIKRPRTAGPaVHFKAMQLSWTS....LALVGIDNQGKL.....SV.LRLSPSMGHPLEVGLALRHLLFLLEYCM
618- 673 (40.43/11.68) ..........................................................LQWVGdfvlYLLASLPNQGSLlrpghSF.LRDGTSLGMLRELMVVIRIWGLLKPSCL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 185.49| 47| 200| 90| 136| 2
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86- 132 (80.98/44.20) CLEWDQSGSRL.L..SADADGQIKCWSM.ADHL.ANSWESSVGSLVEGDPIV
133- 177 (66.60/35.13) ALSWLHNGVKLaL..HVEKSGAS...SF.GEKF.SRVKFSPSLTLFGGKPME
295- 335 (37.92/17.05) ..........L.LcaSSQTSSIVECWSLrKEGLpVNNIFQQISPVVGDKQPT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 77.27| 22| 32| 762| 783| 3
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762- 783 (41.83/23.94) QPK.QPL.RLQFGRAPTLPGSAAT
795- 818 (35.44/19.22) QPKiDHLrRLHLGAYPTEECKACT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.92| 25| 126| 558| 584| 4
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558- 584 (41.86/27.11) STLKSLLRPHFLNTPdkSPGDRLTEI.C
687- 712 (46.05/24.24) SLLFRLLTKLWICFP..SPGPGLVWVlC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 33.67| 10| 35| 714| 726| 5
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714- 726 (13.18/17.98) WqpLPGRDeGPAS
750- 759 (20.48/10.64) W..LPASD.GLVS
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