<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27294

Description mediator of RNA polymerase II transcription subunit 26-like isoform X1
SequenceMPPTVVQLTHRLLQIINKDGTISDQDVALEIIAMLETTVISCEELEETRLGKYINDVRRAATDTSIQRRAKKLIKTWQQMIQVKKRPKTVPEVVAAKTKPVGKPKQAQRTTKQTIVNGEKPNKQRNNSPAKPNEKNKIISKNAKPKVPEIRDSENNQSNNFTCMTNGLKVTFSNLPTKSPSNNISMKHPTKRKRTDENQDFVAKSEKIPAKNNTNISSISLSNVTKVNDVTKTSLETREVTATKTENVNHKPSSPNIEAKTLSDAGEPGSLPRGIDTKDSGPGTSDERPGIDGCRTNNGLWFSWQDGISVQRADLFETNDQDDILTILPYIELD
Length334
PositionUnknown
OrganismCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Tunicata> Ascidiacea> Phlebobranchia> Cionidae> Ciona.
Aromaticity0.03
Grand average of hydropathy-0.853
Instability index44.78
Isoelectric point9.43
Molecular weight37177.58
Publications
PubMed=12481130
PubMed=15114417

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27294
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.13|      48|      48|     200|     247|       1
---------------------------------------------------------------------------
  113-  160 (55.13/27.50)	QTIVNGEKpnkqrnnSPAKPNEKNKIISKNAKPKVPEI.................RDSENNQSNN
  200-  247 (73.64/39.09)	DFVAKSEK.......IPAKNNTNISSISLSNVTKVNDVTK..........TSLETREVTATKTEN
  249-  298 (55.36/27.64)	NHKPSSPN.......IEAK........TLSDAGEPGSLPRgidtkdsgpgTSDERPGIDGCRTNN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27294 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KRPKTVPEVVAAKTKPVGKPKQAQRTTKQTIVNGEKPNKQRNNSPAKPNEKNKIISKNAKPKVPEIRDSENNQSNNFTCMTNGLKVTFSNLPTKSPSNNISMKHPTKRKRTDENQDFVAKSEKIPAKNNTNISSISLSNVTKVNDVTKTSLETREVTATKTENVNHKPSSPNIEAKTLSDAGEPGSLPRGIDTKDSGPGTSDERPGID
85
292










Molecular Recognition Features






MoRF SequenceStartStop




NANANA