<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27280

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVAGQESDWRSNSFRQKLVSQIEEAMRKAGVAHSKSSKDMENHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQSSVSDPMNALQNLTGGPPAGATGIGMASRGPGQSLGGISGLGGVGQPMTLSGQPPPGTSAMPPHAQLQLQQVALQQQQQQQQQQQQQQQQQQQQQFQAQQQVALQQQQQQQQQQQQQQQQQFQAQQSAMQQQQQQFQVAVQQQQQQLQVAVQQQQQHLLKFHHQSQQQLQQQQQLRIAQLQLHQQQQQQQQQQQAALQAQPPPQPPPPSQAMQQQLQQLHHQQQHHPAQPPPQPPPPQVSQGQQPPLPPQAPPAQPLVSQAQSLSGQMMLTPQQLKAMQVRAQIVVQQAQQAQQAQAQAQAQAQAQAQQQQQQQQVAAAQAAQVAQMAAAAAAAAAAAGSQVSQGSMAMMSSPSPVQQAQTPQAMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPASARTPQTFSVPSPGPLNTPVNPSSVLSPASSSQAEEQQYLEKLKQLSKYIEPLRRMINKIDKNEERKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMEAIHGPPITAPIISPRKRKYEEDEKQTIPNVLQGEVARLNPKFLVNLNPSHCSNNGTVHLICKLDDKNLPSVPPLELSVPADYPAQSPLWIDKHWQYGAWGGSRGGGGGGEVSRTS
Length754
PositionTail
OrganismMonodelphis domestica (Gray short-tailed opossum)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Metatheria> Didelphimorphia> Didelphidae> Monodelphis.
Aromaticity0.03
Grand average of hydropathy-0.823
Instability index87.51
Isoelectric point9.58
Molecular weight82464.80
Publications
PubMed=17495919

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27280
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.54|      28|      28|     145|     172|       1
---------------------------------------------------------------------------
  189-  217 (48.28/ 6.41)	QQQQQQQQFQaQQSAMQQQQQQFQVAVQQ
  273-  300 (50.26/ 7.02)	QAQPPPQPPP.PSQAMQQQLQQLHHQQQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.75|      27|      98|     139|     170|       2
---------------------------------------------------------------------------
  242-  270 (47.60/ 6.51)	QQLQQQQQlrIAQL.Q.....LHQQQQQQQQQQQA
  301-  335 (30.15/ 6.40)	HPAQPPPQppPPQVsQgqqppLPPQAPPAQPLVSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.87|      26|      29|     444|     469|       3
---------------------------------------------------------------------------
  129-  166 (39.89/ 7.31)	PPPGTSAMPphaqlqlqqvalQQQQQQQQQQQQQQQQQ
  442-  467 (46.98/10.35)	PPPQPSPQP............GQPSSQPNSNVSSGPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.30|      18|     202|     167|     188|       4
---------------------------------------------------------------------------
  167-  186 (32.93/ 7.66)	QQQQFQAQQQValQQQQQQQ
  366-  383 (31.37/ 7.32)	QAQQAQAQAQA..QAQAQAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.67|      25|      28|     480|     507|       6
---------------------------------------------------------------------------
  481-  505 (45.89/15.74)	SQSPASARTPQTFSVPSPGPLNTPV
  650-  674 (32.78/ 7.11)	IISPRKRKYEEDEKQTIPNVLQGEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.68|      21|      29|     520|     547|       7
---------------------------------------------------------------------------
  532-  560 (16.62/32.33)	SKYIePLRRMinkiDKneERKKdLSKMKS
  569-  589 (37.05/22.84)	SKRC.PLKTL....QK..CEIA.LEKLKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.34|      14|     166|     218|     231|       8
---------------------------------------------------------------------------
  218-  231 (27.43/ 8.57)	QQQQLQVAVQQQQQ
  385-  398 (25.91/ 7.61)	QQQQQQVAAAQAAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27280 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQSSVSDPMNALQNLTGGPPAGATGIGMASRGPGQSLGGISGLGGVGQPMTLSGQPPPGTSAMPPHAQLQLQQV
2) QQQQQAALQAQPPPQPPPPSQAMQQQLQQLHHQQQHHPAQPPPQPPPPQVSQGQQPPLPPQAPPAQPLVSQAQSLSGQMMLTPQQLKAMQVRAQIVVQQAQQAQQAQAQAQAQAQAQAQQQQQQQQVAAAQAAQVAQMAAAAAAAAAAAGSQVSQGSMAMMSSPSPVQQAQTPQAMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPASARTPQTFSVPSPGPLNTPVNPSSVLSPASSSQAEEQQYLEKLKQ
70
265
147
530










Molecular Recognition Features






MoRF SequenceStartStop




NANANA