<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27274

Description Mediator complex subunit 25
SequenceMSLLSLPRVRAKEDGARSKPQPVPRTNMAARAFPAALNRPARVRAQRRRISPHSAVSAAAAVAVAASARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQTAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGTTGQPQPQSTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQILMSGGSRGPVPQPGLQPSVMEDDILMDLI
Length817
PositionUnknown
OrganismCallithrix jacchus (White-tufted-ear marmoset)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Callitrichinae> Callithrix> Callithrix.
Aromaticity0.05
Grand average of hydropathy-0.256
Instability index62.63
Isoelectric point9.48
Molecular weight85563.33
Publications









Function






Annotated function


GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27274
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.59|      21|      24|     414|     437|       1
---------------------------------------------------------------------------
  414-  437 (34.02/10.52)	PSLVSTVAPGSGLAPtaqPGAPSM
  677-  697 (36.57/ 7.69)	PQSTAQPPPGAPQGP...PGAASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     428.40|      59|      60|     294|     352|       2
---------------------------------------------------------------------------
  268-  323 (80.49/17.60)	.....AAPPAL...LEPLQPPTDVSQDPR......................hmvlvRGLVLPVGGGSAPG.....................PLQP.K.QPV.PLPPAAPS
  324-  385 (82.96/18.39)	GATLSAAPQQP...LPPVPPQYQVPGNLSAAQ.....................vaaQNAVEAAKNQKA.G......................LGP.RfSPItPLQQTAPG
  387-  457 (71.47/14.70)	GPPFSQAPAPP...LPPGPPG..APKPPPASQpslvstvapgsglaptaqpgapsmAGTVAP.GGVSGPS.....................PAQL.G.AP..........
  650-  710 (50.88/ 8.08)	........QNL...LQLRPPQ...PQ..P..Q.........................GTVGASGTTGQPQpqstaqpppgapqgppgaasgP.PP.P.GPI.LRPQN.P.
  711-  755 (71.30/14.65)	GAN....PQLRsllLNPPPPQTGVP.PPQASL........................H............H......................LQPpG.APA.LLPPPHQG
  762-  805 (71.30/14.65)	GPPLLH.P.PP...AQSWPAQ....LPPRAPL........................PGQILMSGGSRGPV.....................P.QP.GlQP..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.79|      26|      26|     541|     566|       3
---------------------------------------------------------------------------
  541-  566 (46.34/31.30)	V...QF.HFTNKDLESLKGLYRIMGNGFAG
  568-  594 (34.92/21.78)	V...HFpHTAPCEVRVLMLLYSSKKKIFMG
  596-  616 (20.90/10.09)	IpydQS.GFVN.......GIRQVITN.HKQ
  617-  634 (23.64/12.37)	V...Q.....QQKLEQQQ...RGMGGQQA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.90|      30|     111|     109|     139|       4
---------------------------------------------------------------------------
  109-  130 (32.32/13.70)	........YLLPA.IEYFNGGPPAETDFGGD
  132-  157 (39.06/19.99)	GGTQYSLV.....vFNTVDCAPESYVQCHAP
  158-  177 (26.52/ 7.36)	TSSAYEFVTWLDG.IKFMGGG..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.20|      19|      24|      59|      77|       5
---------------------------------------------------------------------------
   59-   77 (30.93/20.69)	AAAVAVAASARGMVPGSEG
   86-  104 (33.28/22.93)	ADVVFVIEGTANLGPYFEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.66|      20|      35|     203|     225|       6
---------------------------------------------------------------------------
  203-  225 (29.26/29.34)	EQIGQtHRVCLLICnsPPYLLPA
  241-  260 (34.40/21.63)	QQIGE.RGIHFSIV..SPRKLPA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27274 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQTAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGTTGQPQPQSTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQILMSGGSRGPVPQPGLQPSVMEDDILMD
302
614
460
815










Molecular Recognition Features






MoRF SequenceStartStop




1) ILMDLI
812
817