<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27264

Description Mediator complex subunit 12 like
SequenceQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHVASSAGEGPVPVPPDVEQAMKQWEYNEKLAFHLFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLAAHSPHMMIGPSSSSIGAPSPGAPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDSKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWAHQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSEYEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTQPRSPAGDNADEHYPKDHDGSRKSGLVKPGFSQSMDGSPSSQEMFESQTLPSCSLFSPSLPCSAARAPPPEREGVRAEVGPHPRPTVSDTLGVIYDENRGVMYADAFSVFQDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSSTETGVLKHIVPNTTGDKTWVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVANPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSVLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGKAILALSFTVKSGTHFFARRNGKGTSRRSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECPEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQALVREMNNLLDNIAKATIEVFQQSADLNNNSSMCANRKDASLGVTPVSDFSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDTKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGDGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPSSPVSQEPERKSAE
Length1740
PositionKinase
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.07
Grand average of hydropathy-0.272
Instability index51.10
Isoelectric point6.44
Molecular weight193820.11
Publications
PubMed=19892987

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27264
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     410.96|     138|     160|    1285|    1444|       1
---------------------------------------------------------------------------
 1285- 1444 (201.42/190.50)	QKLLQLI..CYpHGIKECPEG..DNLQRQhIKRILQNleqWtlR....QSWLELQLMIKQALVREMN...NLLDNIAKATievfQQSAD.....LNNNSSMCANRKDASLGVTPVSDFssserRGVWLVAPLIARLPTSVQGrvlkaaGEELEKGQHLGSSSKKERDRQKQKSMSL
 1448- 1601 (209.54/142.27)	QPFLSLVltCL.KGQDEQREGllTSLQNQ.VNQILSN...W..ReeryQDDTKARQMMHEALQLRLNlvgGMFDTVQRST....QWTTDwalllLQIITSGTVDMHTNNELFTTVLDM.....LGVLINGTLASDLSNASPG......GSEENKRAYMNLVKKLKKELGDKRSESI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.35|      26|     202|    1054|    1081|       2
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 1054- 1081 (44.16/25.67)	TVLSSEWLG..VLKA...LCCSSNHVwgFNDVL
 1249- 1279 (38.19/16.02)	TICQQEWVGehCLKEperLCTDKELI..LDPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.16|      32|     202|     885|     967|       4
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  885-  930 (46.04/74.90)	SYTTGLCVCIVAVLRRyhsclilnpdqtaQVFeGLCGVVKHVANPS
 1090- 1121 (57.12/14.86)	SFHDSLATFIAILIAR.............QCF.SLEDVVQHVALPS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27264 with Med12 domain of Kingdom Metazoa
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