<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27259

Description Uncharacterized protein
SequenceVESQLEAVFGKALNTDIIVEVFTGFVSLANLDHTKRLKTCIKDFRTLYNSQSTEEHVTSITLLIKFIHKQQHPRRISFMFDFLETCIQDGFLLPRPVLDQLQGAELVHTNRLHWCRTYEVIRKFVHMVDYKGCRNLLHSMVLKMTQIPQSVWIEEKQQVDAICSTIQLLLDPEACLLPGYLAVNEIRQNMQDDLLDAPWFQPLLGKLTEFIDRFRATATMVSTTARWMLLPVVDHAFYQLPSTWKLEADTLRFQLKKQLPYRPEMYQRQHRLLNYILDQTYSRDMVLQVLGMQKHQKQRCEALEMGLVDLMFSTVKKCSTFEDKSNIQHLMWQHVACQVIYFVLYQLASFPHIVEDLHTKLAASEELRDQCIQGGRDYIMWVLLQFISGSIQKNPLSDFLSVIKLVNLLYPEKQPLELPEMKSHSCTISFAAVCNLVHLNRKAQDRNQQWNIPVALHNQHECIKQCLKTTSINLKDSQVALISNACSSNTEMFNMAVSVLVESVFGDTSSTSPMPGNNCVAFNKTVPCSMDLLDTLTVHTKMSMLHSISTKIQKFAQAKSSVGLAPALVETYSRLLIYYEIETLGIKILVSQVVPKVYEYRAWGILNTLLELMSYRMHHIQPNYRIQLLTHLHTLANSPHANQRQLHLRLESTALKLIMGFDNFGIKPQLVRMFNEQKQSIVSQKSEELNRVLVLTLARSIHITVFPFKFSGAESISGSWCTDILKAVMSATPHRWPQQTLACFPQSIQDFFNHSNVTVEPLNKKQLKTNVEQEYINSSGSSLTEADALNHFSQPGTPPYYLCLLWKVLFEEKKLSSTSYKVLERIGASQLSQHVRKFSDFLVYEFSVLEGGSDVKICANVLQDMVWKYNIVFLDRLILCLALRSSEANDVQVAFFIIQYLLIKPDDFLNRVRSFDHDVENLDHWMQDDWHAKHMAYHQKFPEHYFFEGLVAHCSSPEQPNATGEKPQPTYLPTYFCNITLRFLPVLDIVIHRCLELPPSSKSLETLLEHLGLLYKFHDQPVTYLFNTLHYYESKLRGRHLLKKKLVSTIIGAITKNKPPGWILSETFMDYLQQPNDQQWQPDSVYYCQLIQRLATSPVGGKMTSSFSSRDWRFNEFPNASSHALHVTCVEALALPLPGEQVGQALMDVVLKTQSFVEREQSLPWLNAVALVLTALPEIYWKPLHQNILKMLQCPTLTADIEPGSSYPYHILSYSNQQLSFTDMPCTRLLALTHVVWHHMSIGQLSLVSQFLKEEAKPLIETELQLLYIFHLIGPYFPRFQLERTRCMMDVAQLLYNILLRVSKHSSEIHFADEIADFLYHVKYMHIGVAINDRVEEVVVQLQPKLRKRLQFITQAPASSAARQQSAQVHSNTTTEKM
Length1378
PositionTail
OrganismCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Tunicata> Ascidiacea> Phlebobranchia> Cionidae> Ciona.
Aromaticity0.10
Grand average of hydropathy-0.115
Instability index50.20
Isoelectric point7.36
Molecular weight158784.01
Publications
PubMed=12481130
PubMed=15114417

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27259
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.77|      51|      60|     589|     640|       1
---------------------------------------------------------------------------
  589-  640 (84.70/72.75)	LVSQVVPKVYEYRAWGILNTLLELMSYRMHHI..QPNYRIQLLTHLhTLANSPH
  650-  702 (78.07/60.64)	LESTALKLIMGFDNFGIKPQLVRMFNEQKQSIvsQKSEELNRVLVL.TLARSIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     336.38|      85|      90|      86|     173|       3
---------------------------------------------------------------------------
   29-   84 (72.81/50.04)	..................ANLDHTKRLKT.....C.....IKDF...RTLYNSQSTEEHVTSITLLIKFI.......HKQQHP...RRI..SFMFDfLE
   86-  173 (143.18/118.97)	CIQDGFLLPRPVLDQLQGAELVHTNRLHW.....CRTYEVIRKF...VHMVDYKGCRNLLHSMVLKMTQIPqSVWieEKQQVDAICSTI..QLLLD.PE
  175-  264 (120.39/88.79)	CLLPGYLAVNEIRQNMQD.DLLDAP...WfqpllGKLTEFIDRFratATMVSTTARWMLLPVVDHAFYQLP.STW...KLEADTLRFQLkkQLPYR.PE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.46|      53|      65|     454|     510|       6
---------------------------------------------------------------------------
  454-  510 (83.94/73.27)	VALHNQHECIKQCLKTTSINLKDSQValisNACSSNTEMFNMA.VSVLVESVFGDTSS
  520-  573 (83.52/62.75)	VAFNKTVPCSMDLLDTLTVHTKMSML....HSISTKIQKFAQAkSSVGLAPALVETYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.12|      26|      66|     837|     868|       7
---------------------------------------------------------------------------
  837-  868 (38.28/39.73)	KFSDFL..VYEFsvlegGSDVKICANVLQDmVWK
  904-  931 (48.84/31.28)	KPDDFLnrVRSF.....DHDVENLDHWMQD.DWH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.09|      61|     661|     351|     420|       9
---------------------------------------------------------------------------
  351-  420 (91.23/77.53)	PhiVEDLHTKLAASE.ELRdqciqgGRDYIMWVLLQFISGSIQKN.PLSDFLSVIKLVNLLYPEKQPLElPE
 1021- 1083 (104.86/63.77)	P..VTYLFNTLHYYEsKLR......GRHLLKKKLVSTIIGAITKNkPPGWILSETFMDYLQQPNDQQWQ.PD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.44|      18|     633|     742|     762|      10
---------------------------------------------------------------------------
  742-  762 (29.42/26.39)	ACFPQSIQdffNHSNVTVEPL
 1361- 1378 (32.02/18.82)	AARQQSAQ...VHSNTTTEKM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27259 with Med23 domain of Kingdom Metazoa
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