<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27258

Description Mediator complex subunit 25
SequenceYNGDPPAEDLGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQAKQPVPLPPAPPSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQTPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPAAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKVLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAATGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length699
PositionUnknown
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.05
Grand average of hydropathy-0.284
Instability index59.61
Isoelectric point8.78
Molecular weight73131.15
Publications
PubMed=19892987

Function

Annotated function 
GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27258
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     288.50|      60|      62|     485|     546|       3
---------------------------------------------------------------------------
  129-  201 (53.02/ 9.10)	..QGIHFSI.....VSPRKLPALRLLFEKAAPPAmL.......EP.LQPP...TDVS.QDprhmvlvrglvlpvgggsapgPLQAKQPVPL.....P..
  385-  427 (57.85/10.59)	YVNHGENLKTEQ...WPQKLIMQ..LIPQQLLTT.L.......GPLF.......RNS.R......................MVQFH.............
  486-  546 (107.16/28.08)	FVNGIRQVITNHkQVQQQKLEQQRGMGAQQAPPG.L.......GPILEDQ...ARPS.QN.....................LLQLRPPQPQ.....PQG
  548-  617 (70.46/13.25)	.VGA..SAATG..QPQPQGAAQAPP.GAPQGPPG.AapgppppGPILRPQnpgANPQlRS.....................LL.LNPPPPQtgvppPQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.04|      22|     387|     277|     298|       6
---------------------------------------------------------------------------
  277-  298 (50.52/14.87)	PAPPLPPGPPGAPKPPPASQPS
  667-  688 (38.52/ 9.10)	PGQMLLSGGPRGPVPQPGLQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.73|      15|      30|     325|     339|       7
---------------------------------------------------------------------------
  213-  233 (21.54/ 6.38)	APQQPLPPVPQQyqvpgnLSA
  325-  339 (29.19/11.97)	APGGVSGPSPAQ......LGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.99|      15|      25|     439|     453|       9
---------------------------------------------------------------------------
  439-  453 (29.20/22.42)	LYRIMGNGFAGCVHF
  467-  481 (26.78/19.93)	LYSSKKKIFMGLIPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27258 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSAPGPLQAKQPVPLPPAPPSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQTPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPAAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAATGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
233
544
390
744










Molecular Recognition Features






MoRF SequenceStartStop




NANANA