<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27254

Description Cyclin-dependent kinase 19
SequenceMDYEFKSKLSAEREKVEELFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWLEMCTLKFERSESQKKGFKLKLLFLQVITFYVKEGYKEIIKHILCFLQKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSDQALQDLYFQEDPLPTSDVFAGCQIPYPKREFLNEDEPEEKTEKNQQTQNQHQQQTATQQQTTVQQQQVQQQNSSQTNGTGGTAGAALQHSQDSSLNQGPQNKKPRMGPSANNSGGPSLMPSDYQHSSSRLGYQSNVQGSSQPQNAMGYSTTSQQSSQYHQSHRY
Length492
PositionKinase
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana.
Aromaticity0.10
Grand average of hydropathy-0.728
Instability index51.43
Isoelectric point8.25
Molecular weight56515.34
Publications
PubMed=20431018

Function

Annotated function 
GO - Cellular Component
cytosol	GO:0005829	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27254
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.33|      14|      74|       9|      22|       1
---------------------------------------------------------------------------
    9-   22 (24.09/16.12)	LSAEREKVEELFEY
   86-   99 (27.24/19.11)	LSHSDRKVWLLFDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.63|      15|      15|     376|     390|       2
---------------------------------------------------------------------------
  376-  390 (27.63/18.25)	QNQHQQQTATQQQTT
  393-  407 (27.00/17.67)	QQQVQQQNSSQTNGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.63|      15|      15|     458|     472|       3
---------------------------------------------------------------------------
  434-  453 (17.66/ 6.24)	MGPSANNSGgpSLMPsdyQH
  458-  472 (27.97/13.29)	LGYQSNVQG..SSQP...QN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.53|      14|      16|     313|     328|       6
---------------------------------------------------------------------------
  313-  328 (20.95/18.25)	LQKL.LTMDPTKriTSD
  331-  345 (22.58/12.52)	LQDLyFQEDPLP..TSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27254 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKTEKNQQTQNQHQQQTATQQQTTVQQQQVQQQNSSQTNGTGGTAGAALQHSQDSSLNQGPQNKKPRMGPSANNSGGPSLMPSDYQHSSSRLGYQSNVQGSSQPQNAMGYSTTSQQSSQYHQSHRY
352
492










Molecular Recognition Features






MoRF SequenceStartStop




1) AMGYST
473
478