<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27251

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMQPNQEQHIQQQQHMQNMQQMQQQNIQPQQNIQQQNIQQQNIQQQNLQQQNIQQQNLQQQNIQQQNIQQQNLQQQNIQQQQNMQQDSMYINRAGNQQTIYQTNQIQRTPQNNIIQQGSPGMPMRGMAPTNSPMSRTMTGLPSPQSSMGYQRTQWSQPSPGNQQYGAGQFVQPRPPPPTNMQTSYTAIQVFSSMCEQDLKQTIVICLQQKYIVCITIHLYIQPILKMPDSTGQPHSNTIPSLSPNHPSPQVHNTSPGLRTPGSVQAAPSPGGCVNVTIIYPMNKTTTPNIGTLAINTIPSPTPLNNSQVEDDKEYMEKLKQLQKYIEPLSRMISKFNEDEEKYNNDLCKMKTLRDTLMNPNKRLLMSTLDKCEKVLQKVTTPLTPPPLQPPLLQPRPDQHMCQPILNVIASATKSPLLNHTLKRTFGPAMKTLCGNYTIPEFVPNKRQKLQEAVLELRANKAKGKLSDNVKREIANLDSKFNIVVDEVGNDMGGNVQLFCYLNDPKLPGIPPIQISVPQSYPTQPPTWVQGFNYEPSDFLLKLRPMIRSRLTMVNNTHCTISSLLQTWASSAASASTLVH
Length579
PositionTail
OrganismCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Tunicata> Ascidiacea> Phlebobranchia> Cionidae> Ciona.
Aromaticity0.05
Grand average of hydropathy-0.737
Instability index70.63
Isoelectric point9.25
Molecular weight65514.99
Publications
PubMed=12481130
PubMed=15114417

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27251
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.60|      23|      23|      29|      51|       1
---------------------------------------------------------------------------
   14-   37 (40.52/12.35)	HMQNMQQ..MQQQNiqpQQNIQQQNI
   38-   62 (44.83/14.39)	QQQNIQQQNLQQQN.iqQQNLQQQNI
   63-   88 (43.25/13.64)	QQQNIQQQNLQQQNiqqQQNMQQDSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      94.50|      14|      18|     109|     122|       2
---------------------------------------------------------------------------
  109-  122 (27.14/10.32)	PQNNI.IQQGSPGMP
  128-  141 (23.72/ 8.01)	PTNSP.MSRTMTGLP
  143-  157 (20.81/ 6.04)	PQSSMgYQRTQWSQP
  233-  246 (22.83/ 7.41)	PHSNT.IPSLSPNHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     120.19|      25|      25|     345|     369|       3
---------------------------------------------------------------------------
  317-  336 (24.07/ 9.18)	...K..LKQ.LQ.KYIEPLSRMI.SKFN
  345-  369 (41.70/21.46)	DLCK..MKT.LRDTLMNPNKRLLMSTLD
  374-  397 (32.48/15.03)	VLQK..VTTpLTPPPLQPP..LLQPRPD
  399-  421 (21.94/ 7.69)	HMCQpiLNV.IASATKSP...LLNHTL.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27251 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IGTLAINTIPSPTPLNNSQVEDDKEYMEKLKQ
2) KMPDSTGQPHSNTIPSLSPNHPSPQVHNTSPGLRTPGSVQA
3) MQPNQEQHIQQQQHMQNMQQMQQQNIQPQQNIQQQNIQQQNIQQQNLQQQNIQQQNLQQQNIQQQNIQQQNLQQQNIQQQQNMQQDSMYINRAGNQQTIYQTNQIQRTPQNNIIQQGSPGMPMRGMAPTNSPMSRTMTGLPSPQSSMGYQRTQWSQPSPGNQQYGAGQFVQPRPPPPTNMQTSYTA
289
225
1
320
265
186










Molecular Recognition Features






MoRF SequenceStartStop




NANANA