<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27247

Description Mediator of RNA polymerase II transcription subunit 13
SequenceADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKLSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEESADKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGMDTDSASQRLVISAPDSQVRFSSIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTIYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAISSDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNNEREAGKKHKAKDGPSSVTVLSHAKDAMSLFSPSIKQDAPRPSGHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKSGCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWTVGKLELLPSGPALPFIKDGDGSTMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDLSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQSLITPSQMTNTGNANTPSATLASAASSTMTSGVAMSSSVAAANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSINSSTAGSMSTQASTVQNGQLGGQQSAAVQTPGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPSHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSFPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADAMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2150
PositionMiddle
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.08
Grand average of hydropathy-0.413
Instability index51.82
Isoelectric point5.51
Molecular weight236688.33
Publications
PubMed=19892987

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
triglyceride homeostasis	GO:0070328	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27247
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.74|      26|      28|    1076|    1103|       1
---------------------------------------------------------------------------
 1078- 1103 (49.57/34.62)	MNIK.GADVGVYIPDPTQEAQYRCTCG
 1108- 1134 (42.16/21.20)	MNRKfGNNSGLFLEDELDIIGRNTECG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.97|      26|      27|    1471|    1496|       2
---------------------------------------------------------------------------
 1471- 1496 (43.45/25.56)	MTNT...GNANTPSATLASAASSTMTSGV
 1498- 1526 (36.52/20.17)	MSSSvaaANSTLTTTSTSSSSSSNLNSGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.59|      19|      35|    1230|    1248|       3
---------------------------------------------------------------------------
 1230- 1248 (34.21/20.13)	DEALVKSSCLHPWSKRNDL
 1268- 1286 (34.38/20.26)	QDAIQKKRTVRPWGVQGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     268.42|      68|     714|     256|     338|       4
---------------------------------------------------------------------------
  268-  338 (113.81/72.12)	IPTPSSVGSSHCSASCLGVHQVPASTRDP..AMSSVTLTP..PTSPEEVQtvDPQSAQKWVKLSSvSDGFNSDST
  773-  816 (41.01/10.50)	..TPGSKKSANGSDDKSGCKESKTGNLDPlsCISTADLHKmyPTPP.............................
  964- 1025 (113.61/47.07)	MP.PSSAPPSNSGA...GILPSPSTPRFP..TPR..TPRT..PRTPRGAG..GPASAQGSVKYEN.SDLYSPAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.64|      68|     714|     825|     959|       5
---------------------------------------------------------------------------
  507-  577 (114.29/52.65)	NSPQPPPLSPH.PCDVVDEG.VTKTPSTPQSQHFyQMPTPDPLVPSKPMEdrIDSLSQSF.PAQFQEAVEPTIY
  825-  895 (110.35/139.54)	FSPMNMNNKEYgSMDTTPGGtVLEGNSSSIGAQF.KIEVDEGFCSPKPSE..IKDFSYVYkPENCQVLVGCSMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.90|      33|     714|     921|     959|       6
---------------------------------------------------------------------------
  898-  923 (38.46/16.73)	..LKTLPS.QCLPPIKLPEECIYRQ.........................................sWTV
  924-  953 (51.52/33.36)	GKLELLPSGPALPFIKDGDGSTMDQE..............YGPA..........................
 1575- 1640 (32.92/13.18)	GESSSLPTQPH.P...DVSESTMDRDkvgiptdgdshaitYPPAivvyiidpftyenkdestnssnvWTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.36|      26|     714|      14|      42|       7
---------------------------------------------------------------------------
   14-   42 (41.10/26.10)	QGPTSAPILfpvTEEDPILSSFSRCLKAD
  708-  733 (45.26/21.41)	DGPSSVTVL...SHAKDAMSLFSPSIKQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.10|      31|     714|     603|     639|       8
---------------------------------------------------------------------------
  603-  639 (47.51/43.55)	DVEFL...PPQLPS.DKFKDDPVGpfGQESVTSVtelmVQC
 1319- 1353 (49.59/28.44)	DYDFLvlsPFALPYwERLMLEPYG..SQRDIAYV....VLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.71|      34|     714|     437|     493|       9
---------------------------------------------------------------------------
  178-  211 (57.42/24.06)	SNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLI
  443-  476 (59.30/53.10)	SEKPQKRPLTPFHHRVSISDDVGMDTDSASQRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.26|      20|    1053|     685|     704|      10
---------------------------------------------------------------------------
  685-  704 (37.41/25.34)	FLFPDKKDRQNN..ER..EAGKKH
 1740- 1763 (25.85/14.97)	FILAPVKDKQTElgETfgEAGQKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.28|      27|      29|    1809|    1835|      12
---------------------------------------------------------------------------
 1801- 1832 (46.60/26.80)	PNRarrkkGSARRFGLQKLWEW.C.LGLVQMSSF
 1833- 1864 (38.69/20.98)	PWR..vviGRLGRIGHGELKDWsClLSRRNLQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.33|      45|    1053|     342|     390|      13
---------------------------------------------------------------------------
  342-  390 (70.04/74.97)	GGKIPRKLANHVVDRvW..QECN.MNRAQNKRKYSASsggLCEEESADKVAS
 1397- 1444 (67.29/55.54)	GSTASKKLSEKLVAE.WfsQAADgNNEAFSKLKLYAQ...VCRYDLGPYLAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.69|      20|    1397|     477|     499|      14
---------------------------------------------------------------------------
  477-  499 (30.73/27.77)	ISAPDSQvrfSSIRTNDVAKTPQ
 1877- 1896 (35.96/22.79)	ISAADSP...SILSACLVAMEPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.12|      27|      43|    1963|    1991|      20
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 1963- 1991 (39.19/33.26)	PN.NDGADAMGIFDLLDTgDDLDpDIINIL
 2008- 2035 (43.93/26.31)	PHgGDAGKGQGTDRLLST.ESHD.EVTNIL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27247 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSCLRHKNLKPRNPGQQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGMDTDSASQRLVISAPDSQVRFSSIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
2) DLDNLFNSDEDELTPGSKKSVNGSDDKSGCKESKT
3) FPDKKDRQNNEREAGKKHKVEDGPSSVTVLSHEE
4) GPALPFIKDGDGSTMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
5) GSPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
6) SSSVAAANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSINSSTAGSMSTQASTVQNGQLGGQQSAAVQTPGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
424
782
709
954
2019
1521
587
816
742
1039
2050
1627










Molecular Recognition Features






MoRF SequenceStartStop




1) YAFVEGDE
698
705