<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27242

Description Mediator complex subunit 23
SequenceMADSDIFFFQESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLCNKTLQMNDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGNMRISLPGISCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSLALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSQLHSLASVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWALHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLDRIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVNPPMQIQPSYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYELHLRERTSLKRKLVHAIIGSLKDNRPQGWCLSDTYLKYAMNPREESPWIPDDTYYCRLIGRLITPMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALTVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLLITALPEPYWIVLHDRIVSVLSSSSLTSETEWVGYPFQLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLAEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYEMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKDQVEKIICNLRPALKLRLRFITHISKMEPAAVPPQAINSGSPAPQPSQVPVNVALPVTQ
Length1333
PositionTail
OrganismOrnithorhynchus anatinus (Duckbill platypus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Monotremata> Ornithorhynchidae> Ornithorhynchus.
Aromaticity0.10
Grand average of hydropathy0.011
Instability index45.26
Isoelectric point7.57
Molecular weight152489.80
Publications
PubMed=18464734

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27242
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.57|      16|      17|     958|     973|       1
---------------------------------------------------------------------------
  958-  973 (31.59/20.77)	YKFHDRPVTYLYNTL.H
  975-  991 (23.98/13.98)	YELHLRERTSLKRKLvH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     184.03|      40|     133|     547|     586|       2
---------------------------------------------------------------------------
  547-  586 (72.21/42.84)	FISQL..LP.TV.....FKSHAWGILHTL......LEMFSYRM......HHIQPHY....RVQL
  587-  628 (29.91/13.41)	.LSQLhsLA.SV.....PQTN.QNQLHLC......VESTALRLitalgsSEVQPQF........
  631-  671 (35.64/17.39)	FLSD....PkTV.....LSAESEELNRAL......ILTLA.RA......THVTDFFtgsdSIQ.
  674-  719 (46.28/24.80)	WCKDI..L....qtimsFTPHNWA.LHTLscfpapLQAF.FKQ......NNVPQES....RFNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.47|      43|     717|     408|     455|       3
---------------------------------------------------------------------------
  372-  406 (42.10/20.03)	IPVP..................D..............INK..PQSTHAFAM.TCiwihlnrKAQNDNSKL
  408-  450 (77.79/47.88)	IPIP..................HSLKLHHEF.LQQSLCNKTLQMNDYKIAL.LC.......NAYSTNSEC
  470-  525 (28.58/14.84)	ISLPgiscmasgsitplpmnllDSLTVHAKMsLIHSIATRVIKLAHAKSSLaLA.......PA.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.25|      32|     717|     146|     212|       4
---------------------------------------------------------------------------
  146-  205 (45.76/89.10)	KLY.PEGKLPHWLLGN.LVSDFVdtfrptarinsicgrcsllpvvnnsgaiCNSWKLDPTTL
  218-  251 (48.49/23.25)	DLFePQTALLRYVLEQpYSRDMV............................CNMLGLNKQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.72|      40|     717|     260|     313|       5
---------------------------------------------------------------------------
  262-  301 (69.79/59.10)	VLEDQLVDLVVYAMERSETE......EKFDDGGTSQ...............LLWQHLS.SQL
 1126- 1187 (50.92/17.91)	VLHDRIVSVLSSSSLTSETEwvgypfQLFDFTACHQsysemscsytlalahAVWHHSSiGQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.82|      12|      18|     314|     325|       6
---------------------------------------------------------------------------
  314-  325 (21.06/12.32)	HMVLSLHQKLAG
  334-  345 (22.76/13.96)	HLMWVLLQFISG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.84|      23|     262|     934|     956|       7
---------------------------------------------------------------------------
  934-  956 (41.50/27.50)	IHRFLE..LLPVSKSLETLL..DHLGG
 1190- 1216 (32.34/19.59)	IPKFLAevLLPIVKTEFQLLyvYHLVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.45|      31|     262|     739|     813|       8
---------------------------------------------------------------------------
  739-  771 (50.83/91.50)	IITHFSMQGSPPLFLCLlwKMLLETDHINQIGY
  816-  846 (55.62/17.43)	MVWKYNIVTLDRLILCL..AMRSHEGNEAQVCY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.64|      13|     261|    1033|    1051|      13
---------------------------------------------------------------------------
  475-  487 (25.53/ 8.11)	ISCMASGSITPLP
 1039- 1051 (27.11/ 9.42)	ITPMAGKSPGPFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.51|      10|     372|     873|     887|      17
---------------------------------------------------------------------------
  857-  866 (17.69/14.40)	NDFRNRVSDF
  878-  887 (20.82/ 6.59)	NDWHTKHMSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27242 with Med23 domain of Kingdom Metazoa
Unable to open file!