<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27235

Description Cyclin-dependent kinase 19
SequenceMDYEFKSKLSAEREKVEELFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWYLYDFLVLGASNARTQKCPRGIFKKMLFMVLDCIFFLNHNYIFNSNFKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSDQALQDLYFQEDPLPTSDVFAGCQIPYPKREFLNEDEPEEKTEKESQGHRNGTGGTAGAALQHSQDSSLNQGPQNKKPRMGPSANNSGGPSLMPSDYQHSSSRLGYQSNVQGSSQPQNAMGYSTTSQQSSQYHQSHRY
Length464
PositionKinase
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
Lineage
Aromaticity0.11
Grand average of hydropathy-0.625
Instability index45.83
Isoelectric point8.01
Molecular weight53175.74
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27235
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.79|      29|      35|     359|     393|       1
---------------------------------------------------------------------------
  359-  390 (43.53/40.80)	LNEDePEEKteKESQG.HRNGTGGTA..GAALQHS
  395-  426 (47.26/24.86)	LNQG.PQNK..KPRMGpSANNSGGPSlmPSDYQHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.38|      69|      87|     174|     256|       4
---------------------------------------------------------------------------
  174-  252 (110.23/94.42)	MGFA......RLFNSPLKPLADLDpvvvtFW...YRAPELL.LGARHYTKAiDiwaiGCIF...AELLTSEPIFHCRQEDIKTSNPFHHDQL
  259-  340 (102.15/57.13)	MGFPadkdweDIRKMPEYPTLQKD.....FRrttYANSSLIkYMEKHKVKP.D....SKVFlllQKLLTMDPTKRITSDQALQDLYFQEDPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.33|      14|      76|       9|      22|       5
---------------------------------------------------------------------------
    9-   22 (24.09/13.22)	LSAEREKVEELFEY
   86-   99 (27.24/15.67)	LSHSDRKVWLLFDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27235 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKTEKESQGHRNGTGGTAGAALQHSQDSSLNQGPQNKKPRMGPSANNSGGPSLMPSDYQHSSSRLGYQSNVQGSSQPQNAMGYSTTSQQSSQYHQSHRY
353
464










Molecular Recognition Features






MoRF SequenceStartStop




1) HSSSRLGYQSNVQGS
2) KKPRMGP
3) LMPSDY
4) PQNAMGYSTTSQQ
5) QYHQSHRY
425
402
418
442
457
439
408
423
454
464