<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27228

Description Mediator complex subunit 26
SequenceMTAAPVTPREIRERLLQAIDTQSNIHNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTSNEELAKRAKKLLRNWQKLIEPVTQNEQLVRGISNLPGSANGGGSHNCKAEPTPTTLLGGKPIQGLKDRNDIQRAHSPKADKTTNRKRKGEHRDGGLSTPGHVSKPNHELFQNSSPPPTNGIGGSPPENLPSPLDGGLQSNRLEPAENDKHGKIPVNAVRPHTNSPGLVKHPSTSSLLKAVVLQQHSGGLEDVLSHQPRSPRCSSFSPRGTRAELATRQHTTYAPKGSAPSPSQRLPGVDSAHQSPLHPSTPPATAKRLESPRQDRISSPHKPVEQLPSTDCHQVLPRTSQQHTPRSSLVDSQTPRTGFSPESSKVDSDDATSGSDNRKRKKSRLRTEFEGHSADGTGKPARVKKERKLTFDVMTGQIKPLTLKDPVQAESTAPSEQHRTETDKQDPKLCLPSPFQLTNWKELSRNEIIQSYLNRQSSLLSSSGVQTQSAHYYMSEYLKQEECTKREARKTHVLVPIVLPSDLPGRTREITSSDTDRIHNQHWPGVNGCHDTQGNWYDWTQCISLDPHGDDGRLNVLPYVCLD
Length597
PositionUnknown
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana.
Aromaticity0.03
Grand average of hydropathy-0.934
Instability index58.27
Isoelectric point9.38
Molecular weight65909.93
Publications
PubMed=20431018

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27228
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     369.86|      74|      74|     118|     191|       1
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   38-  114 (59.10/21.89)	....LEKYPItkEALEETrlgkliNDVRKKTS..NEE.LA...............KRAKK........LL..RNWQKLIEP...VTQ.NEQ......L..........V................RGISnlPGSANG.GGShncKA
  118-  191 (129.79/56.45)	PTTLLGGKPI..QGLKDR......NDIQRAHSPKADK.TT...............NRKRK........GE..HRDGGLSTP.GHVSKPNHE......L..........F................QNSS..PPPTNGIGGS...PP
  195-  251 (55.23/19.99)	PSPLDGG..L..QS..........NRLEPAENDKHGKiPV...............NAVRP........HT..N......SP.GLVKHPSTSsllkavV..........L................QQHS.................
  253-  327 (68.00/26.24)	.............GLEDV......LSHQ.PRSPRCSS.FS...............PRGTR........AElaTRQHTTYAPkGSAPSPSQR......LpgvdsahqspL................HPST..PPATAKRLES...PR
  345-  448 (57.75/21.23)	DCHQVLPRTS..QQHTPR......SSLVDSQTPRTGF.SPesskvdsddatsgsdNRKRKksrlrtefEG..HSADGTGKP.ARVKKERKL......T..........FdvmtgqikpltlkdpvQAES..TAP............
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27228 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTGQIKPLTLKDPVQAESTAPSEQHRTETDKQDPKLCL
2) NEQLVRGISNLPGSANGGGSHNCKAEPTPTTLLGGKPIQGLKDRNDIQRAHSPKADKTTNRKRKGEHRDGGLSTPGHVSKPNHELFQNSSPPPTNGIGGSPPENLPSPLDGGLQSNRLEPAENDKHGKIPVNAVRPHTNSPGLVKHPSTSSLLKAVVLQQHSGGLEDVLSHQPRSPRCSSFSPRGTRAELATRQHTTYAPKGSAPSPSQRLPGVDSAHQSPLHPSTPPATAKRLESPRQDRISSPHKPVEQLPSTDCHQVLPRTSQQHTPRSSLVDSQTPRTGFSPESSKVDSDDATSGSDNRKRKKSRLRTEFEGHSADGTGKPARVKKERKLTFD
428
90
465
426










Molecular Recognition Features






MoRF SequenceStartStop




NANANA