<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27221

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLALPLSLTPPQPQGTVGASGTTGQPQPQSTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQILMSGGSRGPVPQPGLQPSVMEDDILMDLI
Length478
PositionUnknown
OrganismCallithrix jacchus (White-tufted-ear marmoset)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Callitrichinae> Callithrix> Callithrix.
Aromaticity0.04
Grand average of hydropathy-0.311
Instability index63.11
Isoelectric point9.44
Molecular weight49790.75
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27221
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     248.56|      34|      70|     360|     393|       3
---------------------------------------------------------------------------
   51-   88 (45.22/ 7.63)	PPaPAPPLPPG..............PPGA.PK.......PP.PasqpslvstvaPGSGLAP
   91-  118 (43.64/ 7.09)	QP.GAPSMA..................G...TVAPGGVSGPsP...........AQLGAPA
  360-  392 (63.26/13.76)	PP.PGPILRPQ..............NPGANPQLRSLLLNPP.P...........PQTGVP.
  393-  437 (45.16/ 7.61)	.P.PQASLHHLqppgapallppphqGLG.QPQLGPPLLHPP.P...........AQ.SWPA
  440-  466 (51.27/ 9.68)	PP.RAPL...................PG..QILMSGGSRGP.V...........PQPGLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.55|      19|      24|     188|     206|       4
---------------------------------------------------------------------------
  188-  206 (35.86/24.67)	LTTLGPLFR...N..SRMVQFHFT
  210-  233 (26.69/16.54)	LESLKGLYRimgNgfAGCVHFPHT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.96|      19|      23|     282|     300|       5
---------------------------------------------------------------------------
  282-  296 (22.10/ 6.03)	.....L..EQQQRGMGGQQAPP
  297-  316 (25.35/ 8.15)	GLGPiL..EDQARPSQNLALPL
  317-  336 (24.51/ 7.60)	SLTP..pqPQGTVGASGTTGQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27221 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPPAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLALPLSLTPPQPQGTVGASGTTGQPQPQSTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQILMSGGSRGPVPQPGLQPSVMEDDILMD
50
274
120
476










Molecular Recognition Features






MoRF SequenceStartStop




NANANA