<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27220

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDADSDWRSAPFRQKLVSQIDEAMRKAGVAHTKSSKEMESHVFLKAKTREEYLSLVARLIIHFRDIHNKKTQPAVNDPMNALQNLTGTAVVGGQGLGLGVRPQGAQMGGMGGMAQMAQQMNLPGQPQPGASGMAPHGITGVAAGNQASKLALKEVLTLINPSQNRESELSNESNYKTIKFKTTEYRKTGRDKQPQAASLVAQGQIPSQVMPVTLTPQQQQQGLYAMHRESCQPYSYIDKLCRSTQTSVGKCSRCHQTLLFMISTPMARGGMPVRPRFPPSTVPANPTSTVPLGEQQIPQHLALQEPIPIPEVPVLKDYTMNFPVLTDCAEAPKPLWESALGAIRHCSLPFIFLVPFILANLACMHPLLPATRTALLDLHLSLCTLKMISTPMARGGMPVRPRFPPSTVPANPTSTVPLGEQQIPQVSQNSIPVMSSPSPVQQVQTPQSMPPPPQPSPQPSQPMSQPNSNVSSGPAPSPSSFMPSPSPQPSQSPASARTPQNFSVPSPGPLNTPGNPNSVMSPASTNQSEEQQYLDKLKQLSKYIEPLRRMINKIDKNEERKKDLSKMKSLLDILTDPNKRCPLKTLQKCEIALEKLKNDMAVPTPPPPTVPSTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGQPITKTILLNKYCQDERQSIPNVLQGEVAKLHSKFLVNLDPSQCSNNGTVYLICKLDDKNLPSVPPLQLSVPADYPDQSPLWMDNPRQY
Length741
PositionTail
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana.
Aromaticity0.05
Grand average of hydropathy-0.439
Instability index70.62
Isoelectric point9.31
Molecular weight81124.70
Publications
PubMed=20431018

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27220
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     149.77|      22|      25|     265|     286|       1
---------------------------------------------------------------------------
  265-  286 (45.99/15.48)	PMARGGMPVR.PRFP.........PSTVPANP
  391-  412 (45.99/15.48)	PMARGGMPVR.PRFP.........PSTVPANP
  487-  516 (28.31/ 6.84)	PQPSQS.PAS.ARTPqnfsvpspgPLNTPGNP
  718-  738 (29.48/ 7.40)	PL.QLSVPADyPDQS.........PLWMD.NP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     235.85|      48|     123|     287|     334|       2
---------------------------------------------------------------------------
  204-  233 (46.75/14.85)	.........QIP......SQ.VMPV...TLTP.QQQQQ.......GLYAMHRESCQP
  287-  334 (90.04/34.59)	TSTVPLGEQQIP..QHLALQEPIPI...PEVP.VLKDYT...MNFPVLTDCAEAPKP
  340-  374 (28.39/ 6.47)	..........LGaiRHCSL..PF.I...FLVPfILANLA...CMHPLLPATRTA...
  413-  459 (70.68/25.76)	TSTVPLGEQQIP..Q..VSQNSIPVmssPS.P.VQQVQTpqsMPPP....PQPSPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.79|      27|      28|     564|     590|       3
---------------------------------------------------------------------------
  534-  558 (38.53/17.72)	LDKLKQLSKYI.EPLRRM.INKIDK..NE
  564-  590 (46.30/22.81)	LSKMKSLLDILTDPNKRCPLKTLQK..CE
  593-  620 (40.96/19.31)	LEKLKNDMAVPTPPPPTVP.STKQQylCQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27220 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PSQNRESELSNESNYKTIKFKTTEYRKTGRDKQPQAASLVAQGQIPSQVMPVTLTPQQQQQGLYA
2) RGGMPVRPRFPPSTVPANPTSTVPLGEQQIPQVSQNSIPVMSSPSPVQQVQTPQSMPPPPQPSPQPSQPMSQPNSNVSSGPAPSPSSFMPSPSPQPSQSPASARTPQNFSVPSPGPLNTPGNPNSVMSPASTNQSEEQQYLDKLKQLS
3) VRPQGAQMGGMGGMAQMAQQMNLPGQPQPGASGMAPHGITG
161
394
100
225
541
140










Molecular Recognition Features






MoRF SequenceStartStop




NANANA