<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27178

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGHQTVEFSTLVSRAAEESFLSLKDLMEISKSSDQSDSEKKISLLKFIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAVEVLLTGTYERLPKCVEDVGVQGTLTGDQQKAALKKLDTLVRSKLLEVSLPKEISEVKVSDGTALLCVDGEFKVLVTLGYRGHLSMWRILHLELLVGERGGLVKLEELRRHALGDDLERRMAAAENPFMMLYSVLHELCVALIMDTVIRQVKALRQGRWKDAIRFELISDGNIAQGGSAGSMQMNQDGEADSAGLRTPGLKIVYWLDLDKNSGTSDSGSCPFIKVEPGPDLQIKCLHSTFVIDPLTGKEAEFSLDQNCIDVEKLLLRAICCSRYTRLLEIQKELAKNSQICRTMGDVLLHCHADESEVDNKKSNARECEGQEVLRVRAYGSSFFTLGINIRNGRFLLQSSRNILTPSTLSDCEEALNQGSMTAAEVFISLRSKSILHLFASIGSFLGLEVYEHGFAAVKLPKHILNGSNLLLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPDPSGKSSSFGDMNHVIRIKKIDIGQMQMFEDELNLSLVDWGKLLSFLPNAGVPNQTSEHGLLSEFSLESSMHNPGCPPTSFSSIVDEVFELEKGASLPPFSVPNLSSSYSSPGSHFGAGPMNLPGMKAGASSPKWEGGMQISQINATKVSSVAPHYGGSLYSSGNMKGSMQSSSVSLQSSAPVRSAAGKKLSASKSDQDLASLRSPHSLEIGSGTTMDEDHLRLLSDSSKEAVSGSRSSRLLSPPRPTGPRVPASSSKPNGPRSSPTGPLPGSLRAAGSSSWVTSPTSQAPDSANFHGSSHDVVSKQDTHSRKRSVSDMLDLIPSLQNLEANTRFYKRRKISESAHTLQPLSQALISSEIACKTEGYSYGNLIAEANKGNAPSSVYVSALLHVVRHCSLCIKHARLTSQMEALDIPYVEEVGLRNASSNLWFRLPFSSGDSWQHICLRLGRPGSMYWDVKIIDQHFRDLWELQKGSSNTTWGSGVRIANTSDIDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFALGMRKLLGVRMDEKPEEISANCDGKAPVGVKGVEVSDKLSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPAAGVPGVTAANSSIPKQSGYIPSQGLLPSSSTTNVSQATSGPGVTPPASAASGPLGNHSLHGAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKYFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLEPNFAGGQQTIGLANSNNPNPSSGSQLSAANGNRVGLPNSAGISRPGNQATGMNRVGSALSASQNLAMVNSGLPLRRSPGAGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQPQQQPNSATAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGGDTAPAQKPRIELCLENHAGLKMDESSENSSTSKSNIHYDRSHNSVDFGLTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENSTVSFLGMEGSHGGRACWLRIDDWEKCKHRVVRTVEMSGCSPGDMSQGRLKIVADNVQRALHVNLQGLRDGSGVASNSGAT
Length1826
PositionTail
OrganismVitis vinifera (Grape)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> Vitales> Vitaceae> Viteae> Vitis.
Aromaticity0.06
Grand average of hydropathy-0.179
Instability index44.78
Isoelectric point7.42
Molecular weight197558.73
Publications
PubMed=17721507

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27178
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.36|      65|     294|     298|     372|       1
---------------------------------------------------------------------------
  298-  331 (15.44/24.11)	.........................................................................................................................................................................................................................................................................GSMQMNQDgEADsaglrtpgLKIVYW...LDLDKNSG
  332-  372 (52.61/31.37)	TSDSGSCPFIKVEPGPDlQIKCLHSTF..VIDPLTGKEAEFSL...................................................................................................................................................................................................................................................................
  595-  622 (22.77/ 7.46)	...........................................dqncidveklllraiccsrytrlleiqkelaknsqicrtmgdvllhchadesevdnkksnarecegqevlrvraygssfftlginirngrfllqssrniltpstlsdceealnqgsmtaaevfislrsksilhlfasigsflglevyehgfaavklpkhilngsnlllmgfpdcgssyfllmqldkdfkplfklletqpdpsgksssfgdmnhvirikkidiGQMQMFED.ELN........LSLVDWgklLSFLPNAG
  627-  668 (50.54/25.50)	TSEHGLLSEFSLESSMH.NPGCPPTSFssIVDEVFELEKGASL...................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.47|      17|      18|     816|     832|       2
---------------------------------------------------------------------------
  812-  828 (34.34/18.61)	LLSPPR..PTGP.....RVPASSS
  829-  852 (24.13/10.60)	KPNGPRssPTGPlpgslRAAGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     155.69|      47|      49|     702|     750|       3
---------------------------------------------------------------------------
  681-  704 (33.17/13.95)	.................SSP.GSHFGA..........GPMNLPGMKAGASSP
  705-  753 (77.58/49.99)	KWEGGMQISQINATK.VSSV.APHYGGSL.YSSGNmkGSMQSSSVSLQSSAP
  755-  797 (44.94/21.94)	RSAAGKKLSASKSDQdLASLrSPH...SLeIGSGT...TMDEDHLRLLS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.98|      33|      36|    1222|    1256|       4
---------------------------------------------------------------------------
 1222- 1251 (45.32/23.14)	.....PL..HALAAATRPARAGPAAGVPGVTAANSSI
 1254- 1287 (44.61/26.45)	QSGyiPS..QGLLPSSSTTNVSQATSGPGVTPPASA.
 1288- 1319 (48.05/22.23)	ASG..PLgnHSLHGAAMLAAAG..RGGPGI.VPSSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.67|      10|      36|     130|     139|       5
---------------------------------------------------------------------------
  130-  139 (18.79/13.51)	LPKCVEDVGV
  168-  177 (16.88/11.24)	LPKEISEVKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.34|      14|      36|    1000|    1013|       6
---------------------------------------------------------------------------
 1000- 1013 (28.98/17.55)	NLWFRLPFSSGDSW
 1039- 1052 (27.37/16.11)	DLWELQKGSSNTTW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.44|      24|      49|    1348|    1371|       7
---------------------------------------------------------------------------
 1348- 1371 (46.57/25.53)	FAGDQVWLQPATPPKGGPSVGGSL
 1395- 1418 (43.87/23.57)	FAGGQQTIGLANSNNPNPSSGSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.94|      38|     298|     207|     248|       8
---------------------------------------------------------------------------
  207-  248 (60.04/56.24)	ILHLELLVGERGGLvkleELRRHALGD.DLERRMAAAENPFMM
  503-  541 (60.90/46.19)	ILHLFASIGSFLGL....EVYEHGFAAvKLPKHILNGSNLLLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.40|      13|      30|     374|     389|      16
---------------------------------------------------------------------------
  374-  389 (18.72/19.94)	QNCIDVEKLLLRaicC
  407-  419 (25.69/15.81)	QICRTMGDVLLH...C
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27178 with Med14 domain of Kingdom Viridiplantae
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