<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27142

Description AGAP013275-PA
SequenceMPKLLDSDLDSPIANLIKRGPGATINNGSSSSKQSAHYSNDTTSEKSDGGGPFESIVGRHHLVGGGGGGGLGGVGGNSNSSSSFFSSAYDAKDGSNEGGGSSYGSAAVGLPAGPPALGGPGQPPPLPPQSAFFQSTATATTTASSNHRDGGKGAPAAGPESRVKKYRHQQFSKNIYIGTKNAEKWDTLRNVLLFKNDVEFVSFLLKLAESNCWKKDSPLLNGFASAKSIGGAGKKTKRVQFNKNVNIIHKLEDGNRRKMVSFGEKALADEPAPHQHDEDSAPVPDDEDGGEEDEDDDDDEGEEMEEDAEDPEEDEEEGEDGEEGEEDEEDEEEEEEEGEEKEALAGSGAEGPAEERKVEPAFLGDGSKEEQEQSSVSNHDAYLMDDLVKKTLRKTLPPPTTPASAAPNRQQQSNEVQQDSISSTMGSVSEDSLNTETEVLDYRIAEKIKTELEEKQKLERRAHTGGEELPTTSNFFDQCDQFEPPDEKPPVPAAPKKGLDRSRATGATDRPAHGGVRKRGRRAATAHDSANVDLHIEYEEQEYRPLPGAARGTSTADGGPSAEKAAFLGPAGRQLGLGPHGTAPAGRRPKGTGTAKNKVCTGCSIKHGADQCPLSTPLRAISNKIELTQWLEQNEDLIKKHKLFLKPPGTGDELDDEMDDQYDEDEDDDEDDVEDEEEDGGESSRGNGKVELTPSFSEVSVPPEFELRPCPQSSANGTIISSTTQSADALQLQKLGQLGDSQPPVSLPQQQQQQQGQGHDLQQDQDSLLDSKSSLPPASTLAGFAGTLGADRETAPKSRPAGGHGLSIYTTTFIAKYTKLGPLTGQIVRETEIQDDCTMRHIFETFDGAKSTYTSTENKNFSNWLRYIRPARNREQKNCVLQVHDGSIYFVTCRDLEPGAELLYWSNDSNSAWGKKKMEKTNCGGCNLKFDHPFYYRTHCSVFHDPGFSLTIRKYHCKVCGAAVLGKENIMKHAEKLHDGKGAYQCQFCQKFFLRLNYLEMHRTYGCSANPQRTRPLCDFCGRKFCQPQKLKVHIKRMHSDMADVLRDFQCKLCSKLLGSRAALQRHSKEVHSRNSAVVSCPRCQKLFQNRSNLKIHMLTHSGVRPFKCAENECTAAFTTKQCLQFHYKKVHGYTQEQMPKIERSVAYTFDAYSGGLNDGIIDEVQRRQRHKSTASEEGGYGGEKVERKKRSRQLAHFDETSSLQHQQSELGLGHEPVDQAKVTPQHLQQQLSPQQPQLDYPSTPPAVQRLSTTHPSTGQLVLPSADLLQKDAELHQQKLLRQQQLAAVHQADEQQDEQGVEQSNALHQHELHQADPHLDDPVLGKAEQEQESALHHHHHQQQLARLPSPFSNNLLKTKNILESFNDLCRNESNLSLLSTKISSILNNNLKDIAKVAAIGTPAGSNGGSPGTGEDELKSVGEVDSSFVDMASLASNLKYKEYINGGGNAGLVISKGSKKWISDADQLPGGGGGGDSGGGGQQGAEPGGMLSTVTGRDFLTKLIMNGNVNTPPPNVADEEEEDDDNSTILDVVDSNNPNQQSSHAQLQQATRLQGHFNHQTLLGSFYNNAGTGGAGRNTINTIPTSASMLVEAALNSVSNIITEAEISTNQGGQSQGGLHLSHIDPAASGTDATGSGGGGGGNNNNNNSLSGGTFAAGPIDESVDEMKLLKSHHFSMQLNSISQYSAQSTNDSGILSIRGAGSGRPKSREKLAIYEDSEMLGYEGQQHLGQQLQGTPHNKLTASVDSVRSALSPDGQTGEFGYAATPAAASRQHIGAGGSPVRSSSRQIYAEHDLISPASTPSLPRYDFGPTDAGHYGSAGRRQDAKTISSLTLDSFESNLKDAHHMQQLSSDEDNSIVIAENLSVSAVQSEESKLKLSSGSAAAVAAATNSNAPSNAGSGAADFIQNHQKYGETGRALGGSNLPTTADMRIKYGTDELVDFQRNSAIGDASDFQGLDMSSRSTVSAYHHTNFQLSTQAGSNLHFNRYHHHIYDILSEREQQQQQQQQQQQQQQQQQQQQQQQQPQQQQSQQHHHQQQQAQQQQQQQQQQQQQQHHQHQHQHHHHQHQTQQQQQHTQQQQQQQQQQQQESFQLEQTQLQHLVQEHVQGQDSDADQSVTVDLSRGSSYLVQSPPTPALSYSSHHHPDMIRMVSLDLSSNTGSHHAVNNGSHHAVRHATSFLSTQIQPGDHHRLLAGDQLSAAGNHRLLVSDPATHLIFEQNNRLLSDASGQPAAAAPPPPPPRHVVSPSRGFGAYHHHHHHHHHHQVGSTNYHHSMKQNIASPPINQHGSSAAAAAYHPFPTYY
Length2302
PositionTail
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.883
Instability index56.49
Isoelectric point5.66
Molecular weight250507.52
Publications
PubMed=12364791
PubMed=14747013
PubMed=17210077

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IBA:GO_Central
RNA polymerase II transcription regulatory region sequence-specific DNA binding	GO:0000977	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27142
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     318.25|      33|      33|    2005|    2037|       1
---------------------------------------------------------------------------
  725-  749 (33.03/10.09)	.Q..SADALQLQKL..GQLG..DSQPP..........V..SL.....P...Q
 1220- 1258 (26.40/ 6.28)	......QAKVTPQHLQQQLS..PQQPQldypstppavQRLST.....THPST
 1312- 1340 (38.58/13.29)	LH..QADP...H.LDDPVLG..KAEQE..........QESAL.....HHHHH
 2003- 2035 (69.48/31.08)	QQ..QQQQQQQQQQQQQQQQ..QQQPQ..........QQQSQ.....QHHHQ
 2036- 2067 (68.00/30.23)	QQ..QAQQQQQQQQQQQQQQ..HHQ.H..........QHQHH.....HHQHQ
 2069- 2106 (49.95/19.83)	QQ..QQQHTQQQQQQQQQQQ..QESFQ..........LEQTQlqhlvQEHVQ
 2107- 2143 (32.80/ 9.96)	GQdsDADQSVTVDLSRGSSYlvQSPPT..........PALSY.....SSHHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     158.06|      18|      18|     301|     318|       2
---------------------------------------------------------------------------
  265-  281 (22.00/ 7.62)	KALADEPAPHQHDED....SA
  282-  302 (26.06/10.49)	PVPDDEDGGEEDEDDDddeGE
  303-  322 (28.88/12.48)	EMEEDAEDPEEDEEEG.edGE
  323-  338 (23.28/ 8.52)	EGEEDEEDEEEEEEEG.....
  648-  664 (28.37/12.11)	PGTGDELDDEMDDQYD....E
  665-  681 (29.46/12.88)	D.EDDDEDDVEDEEED...GG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     237.16|      31|      31|    1034|    1064|       3
---------------------------------------------------------------------------
  923-  956 (39.85/20.61)	CGGCNLKFDHPFY............Y..RTH.CSVfhDPgfsltIRKYH
  957-  985 (22.34/ 8.16)	CKVCG.........aavlgkenimkHAEKLH......DG.....KGAYQ
  986- 1016 (46.94/25.65)	CQFCQKFFLRLNYL.........emH..RTYGCSA..NP.....QRTRP
 1018- 1050 (51.62/28.97)	CDFCGRKFCQPQKL.........kvHIKRMHSDMA..DV.....LRDFQ
 1051- 1080 (34.44/16.76)	CKLCSKLLGSRAAL.........qrHSKEVHSRNS..AV.....V...S
 1081- 1108 (41.96/22.11)	CPRCQKLFQNRSNL.........kiHM.LTHSG.V..........RPFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     174.84|      29|      31|     538|     566|       4
---------------------------------------------------------------------------
   62-   86 (26.46/ 8.03)	..LVGGG..GGGGLGGvGG.NSNS...SSSFFS....
   88-  113 (32.27/11.67)	..AYD.A..KDGSNEG.GG.SSYG...SAAVGLP.AG
  510-  543 (29.94/10.21)	RPAHGGVrkRGRRAAT.AH.DSANvdlHIEYEEQ.EY
  544-  572 (49.95/22.73)	RPLPGAA..RGTSTAD.GG.PSAE...KAAFLGP.AG
 1466- 1495 (36.22/14.14)	.QLPGGG..GGGDSGG.GGqQGAE...PGGMLSTvTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.73|      11|      19|    2241|    2255|       5
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 2241- 2255 (17.73/18.92)	RHVVspsrGFGAYHH
 2262- 2272 (24.00/12.60)	HHQV....GSTNYHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.56|      18|      19|    1600|    1617|       6
---------------------------------------------------------------------------
 1582- 1599 (21.28/ 7.09)	I....PTSASMLVEAALNSVSN
 1600- 1617 (29.53/13.10)	I....ITEAEISTNQGGQSQGG
 1618- 1639 (20.75/ 6.70)	LhlshIDPAASGTDATGSGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.79|      18|      19|     346|     363|       7
---------------------------------------------------------------------------
  346-  363 (30.75/14.97)	GSGAEGPAEERKV..EPAFL
  364-  383 (26.04/11.49)	GDGSKEEQEQSSVsnHDAYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.20|      18|      19|    1952|    1969|       8
---------------------------------------------------------------------------
 1952- 1969 (32.99/22.72)	DFQ.GLDMSSRSTVSAYHH
 1971- 1989 (30.21/20.01)	NFQlSTQAGSNLHFNRYHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.06|      13|      18|    1163|    1175|      10
---------------------------------------------------------------------------
 1163- 1175 (22.05/12.43)	DEVQRRQRHKSTA
 1184- 1196 (18.02/ 8.65)	EKVERKKRSRQLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.07|      16|      19|    1897|    1912|      11
---------------------------------------------------------------------------
 1897- 1912 (28.97/18.49)	AGSGAADFIQNHQKYG
 1919- 1934 (29.11/18.62)	GGSNLPTTADMRIKYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.11|      15|      18|    2164|    2180|      12
---------------------------------------------------------------------------
 2164- 2179 (23.91/11.89)	VNNGSHHAVrHATSFL
 2183- 2197 (27.20/10.89)	IQPGDHHRL.LAGDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.09|      24|      24|    1260|    1283|      14
---------------------------------------------------------------------------
 1260- 1283 (38.87/22.38)	QL.VLPSADLLQKDAELHQQKLLRQ
 1285- 1309 (36.22/20.27)	QLaAVHQADEQQDEQGVEQSNALHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.15|      16|      17|    1823|    1838|      15
---------------------------------------------------------------------------
 1823- 1838 (24.37/17.08)	QDAKTISSLTLDSFES
 1841- 1856 (25.63/18.47)	KDAHHMQQLSSDEDNS
 1858- 1873 (21.15/13.51)	VIAENLSVSAVQSEES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.62|      31|      37|     786|     818|      16
---------------------------------------------------------------------------
  761-  785 (30.82/11.25)	..LQQD..QDSLLDSKS......SLPPASTLAG..FA
  786-  818 (48.75/26.80)	GTLGAD..RETAPKSRPAGGHglSIYTTTFIAK..YT
  821-  854 (43.06/18.44)	GPLTGQivRETEIQDDCTMRH...IFETFDGAKstYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.94|      16|      26|    1691|    1716|      17
---------------------------------------------------------------------------
  149-  164 (30.27/10.83)	DGG....KGAPAAGPESRVK
 1691- 1710 (24.67/30.10)	DSGilsiRGAGSGRPKSREK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.75|      17|      26|     580|     599|      18
---------------------------------------------------------------------------
  580-  599 (26.21/18.73)	HGtapAGRRPKGTG..TAKNKV
  607-  625 (27.54/11.94)	HG...ADQCPLSTPlrAISNKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.90|      13|      17|    1514|    1526|      20
---------------------------------------------------------------------------
 1514- 1526 (20.98/13.02)	NVADEEEEDDDNS
 1530- 1542 (21.92/14.03)	DVVDSNNPNQQSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.64|      11|      17|    1779|    1789|      21
---------------------------------------------------------------------------
 1779- 1789 (19.55/11.04)	SPVRSSS..RQIY
 1796- 1808 (16.09/ 7.51)	SPASTPSlpRYDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.86|      12|      60|    1364|    1375|      22
---------------------------------------------------------------------------
 1364- 1375 (21.09/13.86)	SFNDLCRNESNL
 1426- 1437 (18.76/11.36)	SFVDMASLASNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.05|      38|      39|     431|     468|      23
---------------------------------------------------------------------------
  431-  468 (59.65/37.86)	DSLNTETEVLDYRIA.EKIKTELEEKQKLERRAHTGGEE
  471-  509 (62.40/40.00)	TTSNFFDQCDQFEPPdEKPPVPAAPKKGLDRSRATGATD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27142 with Med15 domain of Kingdom Metazoa
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