<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27142

Description AGAP013275-PA
SequenceMPKLLDSDLDSPIANLIKRGPGATINNGSSSSKQSAHYSNDTTSEKSDGGGPFESIVGRHHLVGGGGGGGLGGVGGNSNSSSSFFSSAYDAKDGSNEGGGSSYGSAAVGLPAGPPALGGPGQPPPLPPQSAFFQSTATATTTASSNHRDGGKGAPAAGPESRVKKYRHQQFSKNIYIGTKNAEKWDTLRNVLLFKNDVEFVSFLLKLAESNCWKKDSPLLNGFASAKSIGGAGKKTKRVQFNKNVNIIHKLEDGNRRKMVSFGEKALADEPAPHQHDEDSAPVPDDEDGGEEDEDDDDDEGEEMEEDAEDPEEDEEEGEDGEEGEEDEEDEEEEEEEGEEKEALAGSGAEGPAEERKVEPAFLGDGSKEEQEQSSVSNHDAYLMDDLVKKTLRKTLPPPTTPASAAPNRQQQSNEVQQDSISSTMGSVSEDSLNTETEVLDYRIAEKIKTELEEKQKLERRAHTGGEELPTTSNFFDQCDQFEPPDEKPPVPAAPKKGLDRSRATGATDRPAHGGVRKRGRRAATAHDSANVDLHIEYEEQEYRPLPGAARGTSTADGGPSAEKAAFLGPAGRQLGLGPHGTAPAGRRPKGTGTAKNKVCTGCSIKHGADQCPLSTPLRAISNKIELTQWLEQNEDLIKKHKLFLKPPGTGDELDDEMDDQYDEDEDDDEDDVEDEEEDGGESSRGNGKVELTPSFSEVSVPPEFELRPCPQSSANGTIISSTTQSADALQLQKLGQLGDSQPPVSLPQQQQQQQGQGHDLQQDQDSLLDSKSSLPPASTLAGFAGTLGADRETAPKSRPAGGHGLSIYTTTFIAKYTKLGPLTGQIVRETEIQDDCTMRHIFETFDGAKSTYTSTENKNFSNWLRYIRPARNREQKNCVLQVHDGSIYFVTCRDLEPGAELLYWSNDSNSAWGKKKMEKTNCGGCNLKFDHPFYYRTHCSVFHDPGFSLTIRKYHCKVCGAAVLGKENIMKHAEKLHDGKGAYQCQFCQKFFLRLNYLEMHRTYGCSANPQRTRPLCDFCGRKFCQPQKLKVHIKRMHSDMADVLRDFQCKLCSKLLGSRAALQRHSKEVHSRNSAVVSCPRCQKLFQNRSNLKIHMLTHSGVRPFKCAENECTAAFTTKQCLQFHYKKVHGYTQEQMPKIERSVAYTFDAYSGGLNDGIIDEVQRRQRHKSTASEEGGYGGEKVERKKRSRQLAHFDETSSLQHQQSELGLGHEPVDQAKVTPQHLQQQLSPQQPQLDYPSTPPAVQRLSTTHPSTGQLVLPSADLLQKDAELHQQKLLRQQQLAAVHQADEQQDEQGVEQSNALHQHELHQADPHLDDPVLGKAEQEQESALHHHHHQQQLARLPSPFSNNLLKTKNILESFNDLCRNESNLSLLSTKISSILNNNLKDIAKVAAIGTPAGSNGGSPGTGEDELKSVGEVDSSFVDMASLASNLKYKEYINGGGNAGLVISKGSKKWISDADQLPGGGGGGDSGGGGQQGAEPGGMLSTVTGRDFLTKLIMNGNVNTPPPNVADEEEEDDDNSTILDVVDSNNPNQQSSHAQLQQATRLQGHFNHQTLLGSFYNNAGTGGAGRNTINTIPTSASMLVEAALNSVSNIITEAEISTNQGGQSQGGLHLSHIDPAASGTDATGSGGGGGGNNNNNNSLSGGTFAAGPIDESVDEMKLLKSHHFSMQLNSISQYSAQSTNDSGILSIRGAGSGRPKSREKLAIYEDSEMLGYEGQQHLGQQLQGTPHNKLTASVDSVRSALSPDGQTGEFGYAATPAAASRQHIGAGGSPVRSSSRQIYAEHDLISPASTPSLPRYDFGPTDAGHYGSAGRRQDAKTISSLTLDSFESNLKDAHHMQQLSSDEDNSIVIAENLSVSAVQSEESKLKLSSGSAAAVAAATNSNAPSNAGSGAADFIQNHQKYGETGRALGGSNLPTTADMRIKYGTDELVDFQRNSAIGDASDFQGLDMSSRSTVSAYHHTNFQLSTQAGSNLHFNRYHHHIYDILSEREQQQQQQQQQQQQQQQQQQQQQQQQPQQQQSQQHHHQQQQAQQQQQQQQQQQQQQHHQHQHQHHHHQHQTQQQQQHTQQQQQQQQQQQQESFQLEQTQLQHLVQEHVQGQDSDADQSVTVDLSRGSSYLVQSPPTPALSYSSHHHPDMIRMVSLDLSSNTGSHHAVNNGSHHAVRHATSFLSTQIQPGDHHRLLAGDQLSAAGNHRLLVSDPATHLIFEQNNRLLSDASGQPAAAAPPPPPPRHVVSPSRGFGAYHHHHHHHHHHQVGSTNYHHSMKQNIASPPINQHGSSAAAAAYHPFPTYY
Length2302
PositionTail
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.883
Instability index56.49
Isoelectric point5.66
Molecular weight250507.52
Publications
PubMed=12364791
PubMed=14747013
PubMed=17210077

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IBA:GO_Central
RNA polymerase II transcription regulatory region sequence-specific DNA binding	GO:0000977	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27142
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     318.25|      33|      33|    2005|    2037|       1
---------------------------------------------------------------------------
  725-  749 (33.03/10.09)	.Q..SADALQLQKL..GQLG..DSQPP..........V..SL.....P...Q
 1220- 1258 (26.40/ 6.28)	......QAKVTPQHLQQQLS..PQQPQldypstppavQRLST.....THPST
 1312- 1340 (38.58/13.29)	LH..QADP...H.LDDPVLG..KAEQE..........QESAL.....HHHHH
 2003- 2035 (69.48/31.08)	QQ..QQQQQQQQQQQQQQQQ..QQQPQ..........QQQSQ.....QHHHQ
 2036- 2067 (68.00/30.23)	QQ..QAQQQQQQQQQQQQQQ..HHQ.H..........QHQHH.....HHQHQ
 2069- 2106 (49.95/19.83)	QQ..QQQHTQQQQQQQQQQQ..QESFQ..........LEQTQlqhlvQEHVQ
 2107- 2143 (32.80/ 9.96)	GQdsDADQSVTVDLSRGSSYlvQSPPT..........PALSY.....SSHHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     158.06|      18|      18|     301|     318|       2
---------------------------------------------------------------------------
  265-  281 (22.00/ 7.62)	KALADEPAPHQHDED....SA
  282-  302 (26.06/10.49)	PVPDDEDGGEEDEDDDddeGE
  303-  322 (28.88/12.48)	EMEEDAEDPEEDEEEG.edGE
  323-  338 (23.28/ 8.52)	EGEEDEEDEEEEEEEG.....
  648-  664 (28.37/12.11)	PGTGDELDDEMDDQYD....E
  665-  681 (29.46/12.88)	D.EDDDEDDVEDEEED...GG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     237.16|      31|      31|    1034|    1064|       3
---------------------------------------------------------------------------
  923-  956 (39.85/20.61)	CGGCNLKFDHPFY............Y..RTH.CSVfhDPgfsltIRKYH
  957-  985 (22.34/ 8.16)	CKVCG.........aavlgkenimkHAEKLH......DG.....KGAYQ
  986- 1016 (46.94/25.65)	CQFCQKFFLRLNYL.........emH..RTYGCSA..NP.....QRTRP
 1018- 1050 (51.62/28.97)	CDFCGRKFCQPQKL.........kvHIKRMHSDMA..DV.....LRDFQ
 1051- 1080 (34.44/16.76)	CKLCSKLLGSRAAL.........qrHSKEVHSRNS..AV.....V...S
 1081- 1108 (41.96/22.11)	CPRCQKLFQNRSNL.........kiHM.LTHSG.V..........RPFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     174.84|      29|      31|     538|     566|       4
---------------------------------------------------------------------------
   62-   86 (26.46/ 8.03)	..LVGGG..GGGGLGGvGG.NSNS...SSSFFS....
   88-  113 (32.27/11.67)	..AYD.A..KDGSNEG.GG.SSYG...SAAVGLP.AG
  510-  543 (29.94/10.21)	RPAHGGVrkRGRRAAT.AH.DSANvdlHIEYEEQ.EY
  544-  572 (49.95/22.73)	RPLPGAA..RGTSTAD.GG.PSAE...KAAFLGP.AG
 1466- 1495 (36.22/14.14)	.QLPGGG..GGGDSGG.GGqQGAE...PGGMLSTvTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.73|      11|      19|    2241|    2255|       5
---------------------------------------------------------------------------
 2241- 2255 (17.73/18.92)	RHVVspsrGFGAYHH
 2262- 2272 (24.00/12.60)	HHQV....GSTNYHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.56|      18|      19|    1600|    1617|       6
---------------------------------------------------------------------------
 1582- 1599 (21.28/ 7.09)	I....PTSASMLVEAALNSVSN
 1600- 1617 (29.53/13.10)	I....ITEAEISTNQGGQSQGG
 1618- 1639 (20.75/ 6.70)	LhlshIDPAASGTDATGSGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.79|      18|      19|     346|     363|       7
---------------------------------------------------------------------------
  346-  363 (30.75/14.97)	GSGAEGPAEERKV..EPAFL
  364-  383 (26.04/11.49)	GDGSKEEQEQSSVsnHDAYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.20|      18|      19|    1952|    1969|       8
---------------------------------------------------------------------------
 1952- 1969 (32.99/22.72)	DFQ.GLDMSSRSTVSAYHH
 1971- 1989 (30.21/20.01)	NFQlSTQAGSNLHFNRYHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.06|      13|      18|    1163|    1175|      10
---------------------------------------------------------------------------
 1163- 1175 (22.05/12.43)	DEVQRRQRHKSTA
 1184- 1196 (18.02/ 8.65)	EKVERKKRSRQLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.07|      16|      19|    1897|    1912|      11
---------------------------------------------------------------------------
 1897- 1912 (28.97/18.49)	AGSGAADFIQNHQKYG
 1919- 1934 (29.11/18.62)	GGSNLPTTADMRIKYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.11|      15|      18|    2164|    2180|      12
---------------------------------------------------------------------------
 2164- 2179 (23.91/11.89)	VNNGSHHAVrHATSFL
 2183- 2197 (27.20/10.89)	IQPGDHHRL.LAGDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.09|      24|      24|    1260|    1283|      14
---------------------------------------------------------------------------
 1260- 1283 (38.87/22.38)	QL.VLPSADLLQKDAELHQQKLLRQ
 1285- 1309 (36.22/20.27)	QLaAVHQADEQQDEQGVEQSNALHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.15|      16|      17|    1823|    1838|      15
---------------------------------------------------------------------------
 1823- 1838 (24.37/17.08)	QDAKTISSLTLDSFES
 1841- 1856 (25.63/18.47)	KDAHHMQQLSSDEDNS
 1858- 1873 (21.15/13.51)	VIAENLSVSAVQSEES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.62|      31|      37|     786|     818|      16
---------------------------------------------------------------------------
  761-  785 (30.82/11.25)	..LQQD..QDSLLDSKS......SLPPASTLAG..FA
  786-  818 (48.75/26.80)	GTLGAD..RETAPKSRPAGGHglSIYTTTFIAK..YT
  821-  854 (43.06/18.44)	GPLTGQivRETEIQDDCTMRH...IFETFDGAKstYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.94|      16|      26|    1691|    1716|      17
---------------------------------------------------------------------------
  149-  164 (30.27/10.83)	DGG....KGAPAAGPESRVK
 1691- 1710 (24.67/30.10)	DSGilsiRGAGSGRPKSREK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.75|      17|      26|     580|     599|      18
---------------------------------------------------------------------------
  580-  599 (26.21/18.73)	HGtapAGRRPKGTG..TAKNKV
  607-  625 (27.54/11.94)	HG...ADQCPLSTPlrAISNKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.90|      13|      17|    1514|    1526|      20
---------------------------------------------------------------------------
 1514- 1526 (20.98/13.02)	NVADEEEEDDDNS
 1530- 1542 (21.92/14.03)	DVVDSNNPNQQSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.64|      11|      17|    1779|    1789|      21
---------------------------------------------------------------------------
 1779- 1789 (19.55/11.04)	SPVRSSS..RQIY
 1796- 1808 (16.09/ 7.51)	SPASTPSlpRYDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.86|      12|      60|    1364|    1375|      22
---------------------------------------------------------------------------
 1364- 1375 (21.09/13.86)	SFNDLCRNESNL
 1426- 1437 (18.76/11.36)	SFVDMASLASNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.05|      38|      39|     431|     468|      23
---------------------------------------------------------------------------
  431-  468 (59.65/37.86)	DSLNTETEVLDYRIA.EKIKTELEEKQKLERRAHTGGEE
  471-  509 (62.40/40.00)	TTSNFFDQCDQFEPPdEKPPVPAAPKKGLDRSRATGATD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27142 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQNNRLLSDASGQPAAAAPPPPPPRHVVSPSRGFGAYHHHHHHHHHHQVGSTNYHHSMKQNIASPPINQHGSSA
2) GIIDEVQRRQRHKSTASEEGGYGGEKVERKKRSRQLAHFDETSSLQHQQSELGLGHEPVDQAKVTPQHLQQQLSPQQPQLDYPSTPPAVQRLSTTHPSTGQLVLPSADLLQKDAELHQ
3) IITEAEISTNQGGQSQGGLHLSHIDPAASGTDATGSGGGGGGNNNNNNSLSGGTFAAG
4) KLIMNGNVNTPPPNVADEEEEDDDNSTILDVVDSNNPNQQSSHAQLQQATRLQGHFNHQTLLGSFYNNAG
5) KLLRQQQLAAVHQADEQQDEQGVEQSNALHQHELHQADPHLDDPVLGKAEQEQESALHHHHHQQQLARLPSP
6) KMVSFGEKALADEPAPHQHDEDSAPVPDDEDGGEEDEDDDDDEGEEMEEDAEDPEEDEEEGEDGEEGEEDEEDEEEEEEEGEEKEALAGSGAEGPAEERKVEPAFLGDGSKEEQEQSSVSNHDAYLMDDLVKKTLRKTLPPPTTPASAAPNRQQQSNEVQQDSISSTMGSVSEDSLNTETEVLDYRIAEKIKTELEEKQKLERRAHTGGEELPTTSNFFDQCDQFEPPDEKPPVPAAPKKGLDRSRATGATDRPAHGGVRKRGRRAATAHDSANVDLHIEYEEQEYRPLPGAARGTSTADGGPSAEKAAFLGPAGRQLGLGPHGTAPAGRRPKGTGTAKNKVC
7) LIKKHKLFLKPPGTGDELDDEMDDQYDEDEDDDEDDVEDEEEDGGESSRGNGKVELTPSFSEVSVPPEFELRPCPQSSANGTIISSTTQSADALQLQKLGQLGDSQPPVSLPQQQQQQQGQGHDLQQDQDSLLDSKSSLP
8) NLIKRGPGATINNGSSSSKQSAHYSNDTTSEKSDGGGPFESIVGRHHLVGGGGGGGLGGVGGNSN
9) SDADQLPGGGGGGDSGGGGQQGAEPGGMLS
10) SNAGSGAADFIQNHQKYGETGRALGGSNLPTTADMRIKYGTDELVDFQRNSAIGDASDFQGLDMSSRSTVSAYHHTNFQLSTQAGSNLHFNRYHHHIYDILSEREQQQQQQQQQQQQQQQQQQQQQQQQPQQQQSQQHHHQQQQAQQQQQQQQQQQQQQHHQHQHQHHHHQHQTQQQQQHTQQQQQQQQQQQQESFQLEQTQLQHLVQEHVQGQDSDADQSVTVDLSRGSSYLVQSPPTPALSYSSHHHPDMIRMVSLDLSSNTGSHHAVNNGSHHAVRHATSFLSTQIQPGDHHRLLAGDQLSAAGNHR
11) SSFFSSAYDAKDGSNEGGGSSYGSAAVGLPAGPPALGGPGQPPPLPPQSAFFQSTATATTTASSNHRDGGKGAPAAGPESRVKK
12) YEGQQHLGQQLQGTPHNKLTASVDSVRSALSPDGQTGEFGYAATPAAASRQHIGAGGSPVRS
2217
1160
1600
1501
1279
258
637
15
1462
1895
82
1722
2290
1277
1657
1570
1350
600
776
79
1491
2204
165
1783










Molecular Recognition Features






MoRF SequenceStartStop




1) ESIVGRHHL
2) IANLIKR
3) KAAFLG
4) LIKKHKLFLK
5) RKVEPAFL
6) VSNHDAYLMDDLVKKTLRKTL
54
13
564
637
356
376
62
19
569
646
363
396