<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27139

Description Cyclin-dependent kinase 8
SequenceMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLLTWALPDYLIHL
Length164
PositionKinase
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.11
Grand average of hydropathy-0.426
Instability index32.54
Isoelectric point9.10
Molecular weight19304.15
Publications
PubMed=15057823

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27139
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.01|      41|      75|       6|      51|       1
---------------------------------------------------------------------------
    6-   51 (64.33/44.98)	KVKLSSERERVEDLFEYegckvGRGTYGHVYKAKRKDGKDDKDYAL
   83-  123 (73.69/40.75)	KVFLSHADRKVWLLFDY.....AEHDLWHIIKFHRASKANKKPVQL
---------------------------------------------------------------------------











Associated diseases
Disease
Cardiovascular diseases , cancer	PMID:24751643 PMID:24746821 PMID:33257171 PMID:24754906 PMID:29266937 PMID:32463833 PMID:32752128 PMID:28220308 PMID:29780169
breast cancer	PMID:31988137 PMID:24427329 PMID:32078847 PMID:26452386 PMID:31622095 PMID:28147342 PMID:31087707 PMID:33173974
colon cancer	PMID:31988137 PMID:28231524 PMID:21806996 PMID:20514474 PMID:19808961 PMID:26235356 PMID:22104393 PMID:33291686 PMID:29967145
prostate cancer	PMID:27678455 PMID:32078847
melanoma	PMID:22035865 PMID:32078847 PMID:23454913 PMID:26235356
colorectal cancers	PMID:22035865 PMID:30594029 PMID:22945643 PMID:28191946 PMID:27490956 PMID:23454913 PMID:18794900 PMID:21179167 PMID:19790197 PMID:32596239
endometrial cancer	PMID:31520353 PMID:23454913
uterine cancer	PMID:31520353
gastric cancer	PMID:28231524
lung cancer	PMID:32802198
acute myeloid leukemia	PMID:31382571
cancer  cardiovascular diseases  metabolic diseases	PMID:30352217
inflammatory disorders  viral infections  cancer	PMID:28855340
Gastric adenocarcinoma	PMID:21344156
pancreatic cancer	PMID:29856990 PMID:25305448
colon cancer hepatic metastasis	PMID:30185549
cardiovascular diseases	PMID:31255603 PMID:30352217
Congenital heart disease	PMID:30905399 PMID:24751643
inflammation diseases	PMID:33257171
metabolic diseases	PMID:30352217
periodontitis	PMID:32978798



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27139 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) DKDYALKQIE
2) DLFEY
3) FKVKL
4) RGTYGHVYKAKRK
46
18
5
29
55
22
9
41