<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27139

Description Cyclin-dependent kinase 8
SequenceMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLLTWALPDYLIHL
Length164
PositionKinase
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.11
Grand average of hydropathy-0.426
Instability index32.54
Isoelectric point9.10
Molecular weight19304.15
Publications
PubMed=15057823

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27139
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.01|      41|      75|       6|      51|       1
---------------------------------------------------------------------------
    6-   51 (64.33/44.98)	KVKLSSERERVEDLFEYegckvGRGTYGHVYKAKRKDGKDDKDYAL
   83-  123 (73.69/40.75)	KVFLSHADRKVWLLFDY.....AEHDLWHIIKFHRASKANKKPVQL
---------------------------------------------------------------------------











Associated diseases
Disease
Cardiovascular diseases , cancer	PMID:24751643 PMID:24746821 PMID:33257171 PMID:24754906 PMID:29266937 PMID:32463833 PMID:32752128 PMID:28220308 PMID:29780169
breast cancer	PMID:31988137 PMID:24427329 PMID:32078847 PMID:26452386 PMID:31622095 PMID:28147342 PMID:31087707 PMID:33173974
colon cancer	PMID:31988137 PMID:28231524 PMID:21806996 PMID:20514474 PMID:19808961 PMID:26235356 PMID:22104393 PMID:33291686 PMID:29967145
prostate cancer	PMID:27678455 PMID:32078847
melanoma	PMID:22035865 PMID:32078847 PMID:23454913 PMID:26235356
colorectal cancers	PMID:22035865 PMID:30594029 PMID:22945643 PMID:28191946 PMID:27490956 PMID:23454913 PMID:18794900 PMID:21179167 PMID:19790197 PMID:32596239
endometrial cancer	PMID:31520353 PMID:23454913
uterine cancer	PMID:31520353
gastric cancer	PMID:28231524
lung cancer	PMID:32802198
acute myeloid leukemia	PMID:31382571
cancer  cardiovascular diseases  metabolic diseases	PMID:30352217
inflammatory disorders  viral infections  cancer	PMID:28855340
Gastric adenocarcinoma	PMID:21344156
pancreatic cancer	PMID:29856990 PMID:25305448
colon cancer hepatic metastasis	PMID:30185549
cardiovascular diseases	PMID:31255603 PMID:30352217
Congenital heart disease	PMID:30905399 PMID:24751643
inflammation diseases	PMID:33257171
metabolic diseases	PMID:30352217
periodontitis	PMID:32978798



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27139 with CDK8 domain of Kingdom Metazoa
Unable to open file!