<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27138

Description Mediator of RNA polymerase II transcription subunit 24 (Fragment)
SequenceMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDIE
Length791
PositionTail
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy-0.017
Instability index46.10
Isoelectric point6.56
Molecular weight88348.87
Publications
PubMed=16625196
PubMed=21269460

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27138
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.27|      27|      29|     250|     277|       1
---------------------------------------------------------------------------
  250-  277 (41.67/38.49)	TEELKwTAFTF.LKIPQVLVKLKKYSHGD
  281-  308 (45.59/34.51)	TEDVN.CAFEFlLKLTPLLDKADQRCNCD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.38|      83|     115|     566|     651|       2
---------------------------------------------------------------------------
  566-  651 (129.23/88.51)	LAVCAVAWLVAHVRMLGLDEREKSlQMIRQLaGPLFSENTLQFYNERVVIMNSILERMCADVlQQTATQIKFPSTGVDTMPYWNLL
  686-  768 (144.15/86.68)	LHMGGVYWFCNNLIKELLKETRKE.HTLRAV.ELLYSIFCLDMQQVTLVLLGHILPGLLTDS.SKWHSLMDPPGTALAKLAVWCAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.47|      32|      68|     431|     466|       3
---------------------------------------------------------------------------
  432-  466 (51.78/40.13)	STKPASVRALLFDISFLMLChvaQTYGSEVILSES
  501-  532 (53.70/38.91)	STKVESLVALLNNSSEMKLV...QMKWHEACLSIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.20|      58|      68|      42|     108|       4
---------------------------------------------------------------------------
   42-  100 (96.99/60.23)	LCVQALLDIMDMFCDRLSCH.GKAEECIGLcRALLSALHWLLRCTAA.SAERLR.EGLEAGT
  110-  170 (84.22/36.82)	MCLQRLEKTLSSTKNRALLHiAKLEEASSW.TAIEHSLLKLGEILANlSNPQLRsQAEQCGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.02|      18|     241|     229|     248|       6
---------------------------------------------------------------------------
  229-  248 (31.09/23.59)	PLFvlEIW.KACF..VGLIESPE
  473-  493 (28.93/15.78)	PFF..ETWmQTCMpeEGKILNPD
---------------------------------------------------------------------------











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27138 with Med24 domain of Kingdom Metazoa
Unable to open file!