<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27130

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceKELWIFWYGEEPDLSGLVSPELIACESEQGSWESGLSYECRSLLFKALHNLIERCLLSRDFVRLGKWFVQPYNGYEKHRCSSSHLSFSFAFFVHGESTVCASVDVRQHPAVRHLTKTCLQRTQTSQSGVKVILAPYGLAGTLTGQVSRMDSQLLEEWKHFYPISTGSNPETGLPPLVEVLVGGVRMRYPSCYVLVTDMDDTPPETPLSPPSSPVTCERPLLTQQELSAATELPERVWAECTLSSPVSASKTESSTEPGTWTFVEPTQKSSCTCSCSKYTTPGGWKSLASSQVQRERVDKGGRRVVPFHRRSTTQWDACPSVPANAPRSVLSRTEAPSTPPGGPPSYSRGPPTGGDCLPVPSVGSPSSPAPSPLLTPHSEPASVPPAEPTMPTLSPQPPPSHTNTALPLTPSQGPKSISSACNNQVHSPSVPGPVLKRPILVSREYEGALLEDEQPLSWLYDYSLQEAWLNHPVKRFKSMNISTPPTNRSNILYPPMNSQTLQSQAPKLEIKQEPVAVGECIGRRTDPYEFDATGEENGTNVDGLRRQRDDPTKPGSLFTSEGLQPSYKDLDQIFDNSDPDTSSDETNLNQLQIQTPPGSNKSGGLHEETRVDGANKNNNRGVTVLRPEELSKMFPTPPSLEHNPVASPCQLSDPLMDQTELLMPSRPLRHLPDIYPNMGSPQEEPIDDWSYVFKPAAISKMVGSSKYAPLTNLPSQSLPSITLPSHCVYRPSWQCNSASTNQADKPLPPTRPGSVQQQQQQQQQQQQQQQQQQQQQQQQPCPQSPAPPYRSNTLPGRPPPPPYDQPSPATSTTSSYLNKNLNSIEADTPGPARAPESNSLVVNILLGDTALNIFRDHNFDSCSLCVCNAGPKVVGNIKGADAGVYLSNSWVGSALFQDDDQIRCSCGFSAVVNRRLAHRAGLFYEDEMEITGVAEDPAEKKKGSLTAVACPGAKAAPEGLDTIPPNVLELLREQCLIVQSSASSLYRAARICATVKSYPTLTPTVNTLEFNDGNEVCVAALDQGKLDGAHNERAARVNGVHRWVFLRARGPQCSGDIVRMMRSLQPLLQDAVQKKCTTRMWEAPYTVTGPLTWRQFHRLAGRGTDDRCEPQPIPALVVGYDRDWLSLSPYAVCFWEKLSLEPFAGHRDVAYVVVAPDSDCIVNRVKSFFRELSCTYEICRLGRHTPISKQLRDGILRVGKSTVQKLAKQPMDDWFKFLGENHIGELLRLYAQVCNHRLAPYLTQVIQDRSLLDPGDSQQANKQQQQQSTTIPVPDTMPATPDVLSTKPESVEGENPRSETPSSSTATNQTTTNTTGNTTPTSQPTSNTPITTTTGPDEEEIEPPAIVVYFVEPFSLGGTEDPDRRRLAILALLRAYSSAINSMPENMRSNIHVQIISLESIMELGRARERRKIQDEMRALALNVFLQGRRLLNHNSTVKSLTGFGTAAAADIFLKSKDERNRAPYRLYAPAFVLAPLRAKSEAPESFGMPRPEECAVLYLSYCLSEDQSWLLAAATDDRGEIFETATINIDIPNRKRRKRASARRIGLQKLMDFILSVMSQGVQPWRLVVGRVGRIGHGELKGWSWLLSRKALLKASKHLKEICGQCSLLYPSAAPCVLSACLVSLEPDSTLRLMADQFTPDERFSQASVNCQLSTPQDVTCTHILVFPTSATTQSSQTAFQEQHNVPELGDDELFSALNDDMPEGMEGMGDFNDIFNVWPEPGAGGGQSPSGSPHRPEGSPHGGDGGGSGLGNHDGPGSPFPCSNTPRIATTEQAEEVGTLLQQPLALGYLVSTAPTGRMPSWFWAACPHLENVCPVFLKNALHLHSPAIQQNSDDLLQQQNAPTAHPLDSQYTTDVLRYVLEGYNALSWLALDANTKDRLSCLPVHVQALMHLYHATAALV
Length1903
PositionMiddle
OrganismAcromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Acromyrmex.
Aromaticity0.07
Grand average of hydropathy-0.467
Instability index63.00
Isoelectric point5.82
Molecular weight208783.72
Publications
PubMed=21719571

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27130
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     811.12|     195|     196|     378|     572|       1
---------------------------------------------------------------------------
  202-  353 (198.47/90.72)	.................................PPETP........LS..PPSSPVTCERPLL.TQQELSAATELPERVWA..EcTLSSPVSASKTESSTE.PGtwTFVEPTQKSSctcSCSKYTTPGGW......KSLASSQVQRERVDKGGRRVVPFHrrSTTQWDACPSV................PANAPRSVL................SRT...........EAPSTPPGGpPSYSRG...PPTG
  354-  553 (328.62/156.35)	GDCLpVPSVGSPSSPAPSPL...ltphSEPASVPPAEP....TMPTLSPQPPPSHTNTALPLTPSQGPKSISSACNNQVHS..P.SVPGPVLKRPILVSREYEG..ALLEDEQPLS...WLYDYSLQEAWLNH.PVKRFKSMNISTPPTNRSNILYPPMN..SQTLQSQAPKLEIKQE...........PVAVGECIG................RRTDPYE..FDATGEENGTNVDG.LRRQRD...DPTK
  554-  751 (225.99/104.59)	PGSL.FTSEGLQPSYKDLDQ...ifdnSDP.DTSSDET....NLNQLQIQTPPG.SNKSGGL...HEETRVDGANKNN..............NRGVTVLRPEEL..SKMFPTPP.S..............LEHnPVA..SPCQLSDPLMDQTELLMPSRP..LRHLPDIYPNMGSPQEepiddwsyvfkPAAISKMVGsskyapltnlpsqslpSITLPSHcvYRPSWQCNSASTN.....QADkplPPTR
  752-  835 (58.03/19.90)	PGSV.QQQQQQQQQQQQQQQqqqqqqqQQPCPQSPAPPyrsnTLPG.RPPPPPYD.......QPSPATSTTSSYLNKNLNSieA.DTPGPA.RAP............................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     527.13|     163|    1709|       5|     180|       2
---------------------------------------------------------------------------
    5-  180 (260.14/181.24)	IFWYGEEPDLSGLVSPELIACESEqGSWE......SGL.SYECRSLLFKALHNliERCLLSRDFVRLGKWFVQPYN.GYEKHRCSSSHL.SFSFAFFVHGEStVCasvDVRQHPAVrHLTKTCLQrtQTSQSGVKVILAP..YGLAGTLTGQVSRMdsqLLEEWKHFYPISTGSNPE...TGLPPLVEVL
 1716- 1892 (266.99/152.89)	IFNVWPEPGAGGGQSPSGSPHRPE.GSPHggdgggSGLgNHDGPGSPFPCSNT..PRIATTEQAEEVGTLLQQPLAlGYLVSTAPTGRMpSWFWAACPHLEN.VC...PVFLKNAL.HLHSPAIQ..QNSDDLLQQQNAPtaHPLDSQYTTDVLRY...VLEGYNALSWLALDANTKdrlSCLPVHVQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.12|      19|      37|     865|     885|       4
---------------------------------------------------------------------------
  865-  885 (32.14/30.35)	CVCnaGPKVVGNIKGAD.AGVY
  904-  923 (31.99/22.17)	CSC..GFSAVVNRRLAHrAGLF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27130 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TTQSSQTAFQEQHNVPELGDDELFSALNDDMPEGMEGMGDFNDIFNVWPEPGAGGGQSPSGSPHRPEGSPHGGDGGGSGLGNHDGPGSPFPCSNTPRIATTEQAEEV
2) VIQDRSLLDPGDSQQANKQQQQQSTTIPVPDTMPATPDVLSTKPESVEGENPRSETPSSSTATNQTTTNTTGNTTPTSQPTSNTPITTTTGPDEEEIEPPAI
3) VKRFKSMNISTPPTNRSNILYPPMNSQTLQSQAPKLEIKQEPVAVGECIGRRTDPYEFDATGEENGTNVDGLRRQRDDPTKPGSLFTSEGLQPSYKDLDQIFDNSDPDTSSDETNLNQLQIQTPPGSNKSGGLHEETRVDGANKNNNRGVTVLRPEELSKMFPTPPSLEHNPVASPCQLSDPLMDQTELLMPSRPLRHLPDIYPNMGSPQEEPIDDWSYVFK
4) WKSLASSQVQRERVDKGGRRVVPFHRRSTTQWDACPSVPANAPRSVLSRTEAPSTPPGGPPSYSRGPPTGGDCLPVPSVGSPSSPAPSPLLTPHSEPASVPPAEPTMPTLSPQPPPSHTNTALPLTPSQGPKSISSACNNQVHSPSVPGPVLKRP
5) WQCNSASTNQADKPLPPTRPGSVQQQQQQQQQQQQQQQQQQQQQQQQPCPQSPAPPYRSNTLPGRPPPPPYDQPSPATSTTSSYLNKNLNSIEADTPGPARAPESNSLV
1673
1245
473
284
733
1779
1346
694
438
841










Molecular Recognition Features






MoRF SequenceStartStop




1) LWIFWY
3
8