<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27127

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMGILYEKRPLKRPRLGPPDVYPQELKQKEDELSLTNVKHGFMATTTQLTDESGTGRNYNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGSKPLVTLAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQDNGTGNNQPSTPTSSSQSATGSTMNEEHKLALKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLAYLCCRKLAHMCNNVESNNNPQSPSITKNEINGSKDTTVAVQGSLNLLTVAFNDYLTCAHHRDVIYSLSTIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLLCPPAALPCPPASSGNPTMKQLRIAQENIRARSQAAEGRWSCDKWQQSSAGTTTTKVLAALDALDRHSFDKMDASNSLDTLYAKIFTPSPKDNSSERDTKTEYNPQQDSAIVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSTCSNGSPPVLPIFQPLLMKFLDMDAPVLDNTSNQSKAQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVSDHGRTMDYDDSKIDDDLDKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRVRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAVTMKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVHEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEAQLTARNSQLVRSYTTNLSLYIVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSTCSLLKTKSHGVEAFSNAYPKIRAALYSTLQPTPSSHVYNSQFMVDVFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSSSSAFYIDVLNQVDVQDLSIHNSLAIFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDIDIEVEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAAKQPPKKVDIPLSHSTKGGGPASVGVGVGVSSSGPGELSISHILGTSDILGGGDDLGLDLAMSSSSSSAGMTTENVKGFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDNMLTPRQAQKLLHMICYPETPTEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFTPSSSELSQWLDTVAKAAIDVFQLNNTLSNKSDKKSGSIWLVAPLVSKLPSAVQGRVLKVAGQGLESGNWSKTAGRERGRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKHIGSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSSSIRFVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAVRLERKPLTYQNAHKLLRYHTHSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSVGSTGVGNVNTNGKGKAMKNKRHNRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQQGIYAGIQQGMNQNYAGYGGQQMMQQQQQQQQQTSQQTQQQQQQQLLQQQQQQQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYIPQQRMQPSAARPPYLQAPNVTMNAMGPMGAGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQGAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
Length2213
PositionKinase
OrganismAcromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Acromyrmex.
Aromaticity0.06
Grand average of hydropathy-0.501
Instability index52.23
Isoelectric point7.53
Molecular weight245972.01
Publications
PubMed=21719571

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27127
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     335.51|      26|      26|    2005|    2030|       1
---------------------------------------------------------------------------
 1829- 1856 (36.03/12.32)	QQM.QQPPS.QLQQMAfgnQQAP.V..AQQPGM
 1859- 1882 (38.23/13.58)	GQ..PPQPQ.QQWYSN...QQTH.T..PAQQYG
 1885- 1910 (26.80/ 7.05)	QQLPPTPVG.GPRYER...PGMN.N..QSKQAL
 1942- 1969 (31.63/ 9.81)	FQGMQRQFI.RQQLRA...QHGA.PgiNPQQGM
 1973- 1998 (39.70/14.41)	QQQQQQQQQ.QQQQGI...YAGI.Q..QGMNQN
 2005- 2030 (51.13/20.94)	QQMMQQQQQ.QQQQTS...QQTQ.Q..QQQQQL
 2032- 2054 (41.36/15.36)	Q...QQQQQ.QQQQQQ...QQGI.L..NQQQSM
 2060- 2086 (30.77/ 9.32)	QQMMGPQRG.QEYIPQ...QRMQpS..AARPPY
 2155- 2180 (39.85/14.50)	LAMQQQQQQaQQQQAA...QQ.Q.Q..QQQQGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.12|      36|      40|      79|     117|       2
---------------------------------------------------------------------------
   79-  117 (59.09/42.08)	LATMpdtGRKRQQINPKDNFWPVTARTKNGI..EAWFKDLS
  122-  159 (58.03/33.25)	LVTL...AKKAPNFNKKEEIFMMLCEYQVPMlrAAWFIKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.31|      10|      15|    1321|    1330|       3
---------------------------------------------------------------------------
 1321- 1330 (19.36/10.24)	QICSQEWVLE
 1338- 1347 (17.95/ 8.92)	ELCHQDMLLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.50|      15|      15|    1247|    1261|       5
---------------------------------------------------------------------------
 1227- 1241 (19.41/ 7.67)	VGDA.TAAKQPPKKVD
 1242- 1257 (19.54/ 7.77)	IPLShSTKGGGPASVG
 1274- 1289 (17.54/ 6.18)	HILGtSDILGGGDDLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.69|      16|      19|    1038|    1053|       6
---------------------------------------------------------------------------
 1038- 1053 (27.65/17.28)	CNAIVAVCSETDNDKL
 1060- 1075 (30.04/19.42)	CAELTACCNALNAEWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      15|      15|     272|     286|       8
---------------------------------------------------------------------------
  272-  286 (25.11/17.88)	EDGILKLLLPLALQY
  288-  302 (24.90/17.65)	EEFIQSELLARRLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.87|      27|      45|    1435|    1461|      10
---------------------------------------------------------------------------
 1435- 1461 (44.85/33.06)	NKSDKKSGSIWLVAPLVSKLPSAVQGR
 1482- 1508 (44.02/32.27)	ERGRSKSPSLFNHQPFLSLVLTCLKGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.66|      16|      19|    2089|    2104|      11
---------------------------------------------------------------------------
 2089- 2104 (30.28/20.34)	APNVTMNAMGPMGAGV
 2109- 2124 (28.38/18.47)	APPYRQSAGKPGAVGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.72|      14|      34|     982|     995|      20
---------------------------------------------------------------------------
  982-  995 (24.22/14.23)	KIRAALYSTLQPTP
 1017- 1030 (26.49/16.37)	KIEPQWARQLNETP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27127 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPS
2) NYAGYGGQQMMQQQQQQQQQTSQQTQQQQQQQLLQQQQQQQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYIPQQRMQPSAARPPYLQAPNVTMNAMGPMGAGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQGAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
3) THSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSVGSTGVGNVNTNGKGKAMKNKRHNRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQQGIYAG
686
1998
1742
726
2213
1990










Molecular Recognition Features






MoRF SequenceStartStop




1) LYAKIF
2) MGILYEKRPLKRPRL
3) NMLRLRL
4) QQPTPQLVTHLQRHL
486
1
1912
2184
491
15
1918
2198