<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27125

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMVERLESLARQLGLKFMMSGPPGTEIFISSDMFFLEVLLEPPSGLVRDVKIHHEGKSEQQSCEALASALSRGDFVDFTTQLEGLASIYQLNADKKVKCKAFSALQSLEADLGILAQLQTFMKEPFNLVHKSPVGILERRRGGHPMKLTYFVSPYDLIDEENRTYDALNSDTIIKRKIGHSVTVCMEGSTGHKLPTSSIITVNRSPTGKSTPSYAPLTSTNSSMLPACFVLKLVKKMPICMELVKRIQKVTELECGDISAPHPLLSLIIQHASDGQLDCRNNRGLYVTLPDQQHCYFMTENKNMEGVLVCSIPFTHPAHVPQILVYLRQQALFNCLIASCVRPMARQDPEHTTILEVSALSWQHISVSVEHPYEETMATAELDLTDISTLKCRLYGMSMTTNVEQTSDLSGRVLQRCLSIPLTMRMLLKIWEGRSLPAVMNSLTSGSGSSNGSYNLNLGSGGKDQTGQNASGTASDAGTENSIGFPSYSGQSDTTTMGTTGTNSTSTSMLNPLQLGALLGQAKNSLTSNSNTNERGKKTRKRKTGTDGLWRSPKRKSDGGDSSAATEILLESSSSENSTPLGTPTSRENLAETRTSTPTSATSLTSGMDFSNLDTTDILDKSASDYDLDNSEKDSEIMEVQHSSAEQQQQQQQPQQEVEELIKIRESSSTRKSKKNRSGGGSEEKKSSPTNIFVDETSTTSSGNKGLPVPPSVSITPISCGNLDQASTPNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPTPSPKTSGLTSATEDRQRSERKSGGGKSSGSSSKSSSEDTKSGGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGSVGVGLSCSSSRPTSPAAVRKFSPSPTHSSSLATLVGKSSPTLKAGQSAAATCGKPVQSPKHSPVYGSSPKHNAPNVSVVPMSVPMSLSVSTVPNTVGNVPSVAVSVPVPVPASASPKHGNTSSPKHGSSAASSGKPSMSALKSAANSPSSKSSSSSSSDSATTPSKVKSSSSSSSSKDSSGRGDKDRRTSSVSSSGGSGSGHQSPKTKSSSSKMKQLEIISPGSEATQVSSLQASGGSTPPSGQVDAASKSAIAAQQARNRKSSLNAVIDKLKNAQHCTETDACGNGGGNVKGSGSSGLGSTGGMSSTGQKEKNIGSGGSSSSSGGKTIGEGGKSCVTKNASVDTKNPGEYMVKHSSDGIKITINKTRTKDSKQAANLKLSSSGSMAATSSSSSLSSVASSSSSSSSNVITGSNGSPKTHTGLKPGVNSGPASKKPQTLQATQKMLPTKMMLAAAGMKSAISSSGATNTGSGAGITASATGGVGGNPLSKSSSSKASGSPKTSSGVTDLSRGRDKARISKSGDKGIFASKGLGDARKSSPSALREESESERAFKLLAAHASISNLPPSLPPQLMMEGLMKQLDTKFQIPKLSARANVADADKNKSSDKLSILPDPTKQTLDGLKQEQGKIAGLSNVTVSVSKSSQPDDQSRRDHSQNKPDNLSITTSAAGAMSLNLGENTGLMLPPQSTADSDVPTNLCIQPMVDNESSRDSCKDLGMRQTSGQQFLGKIDDTSVGGILTKSNVSDQLTSSGAKSYGTMTSSNTSTASSGAIVAESLNLSTKPADQAVLQTKYNKITVEEKKQQQTSSASLSSSSSSSSSSSSSIFSSLASVATSSDGNPVITSDSGGGGGSGGGGGGGGEQEVVAAAAAAEMLLDFSAANKDSMTKGGHGLPASLTQHHLTTIPERAMTQAAPTVRRNTPPPPPPPPPLPAPFPPAASPSVSVHIVKSPAPSPRVIPPSPHSSASPCITDDELMDEALVGMGK
Length1853
PositionMiddle
OrganismAcromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Acromyrmex.
Aromaticity0.02
Grand average of hydropathy-0.514
Instability index58.01
Isoelectric point9.21
Molecular weight191873.92
Publications
PubMed=21719571

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27125
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1363.42|     228|     228|     695|     922|       2
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  464-  624 (190.22/46.30)	QT.GQNASGTASDAGTE..........NS.....IG..FPSY.SGQSDTTT...MG..............ttGTNSTS..TS....................MLNPLQLG.....AlL.......GQA....K...NS.LT......................SN.S...NTNER..............G...K.KTR..KRKT.................GTDGL.WRSpKR................KSD...................GGDSSA......ATEilleSSSSEN....ST............................PLGTP..............T....SREN....LAE....TRTST....PTSaT.SLTS.G......MDFSN.L..DTT.DI...LDKSASD
  640-  880 (352.40/92.42)	QH.SSAEQQQQQQQPQQ..........EVEELIKIRESSSTRKSKKNRS......GggseekkssptnifvdETSTTS..SGNK..GLPV....P....PSVSITPISCG.....N.L.......DQA..S.TPNYNSVLT..GMGLE..RRPGIEIIP..IASSPS...QTNLP.....SSITITPIAGPTPSPKTS..GLTS.................ATEDR.QRS.ER................KSG...................GGKSSG......SSS....KSSSEDTKSGGSKLE......KR.........RKRKREDGPMGPP........DKV...P....SGGK....QQQ....DPLSK....PVS.V.SIKP.S......TEQSP.P..SGG.SVGVGLSCSSSR
  881- 1117 (218.58/54.36)	PT.SPAAVRKFSPSPTH..........SSSLATLVGKSSPTLKAGQSAAAT...CG...........kpvqsP..........K..HSPVygssPkhnaPNVSVVPMS..............................V....PMSL......SVSTVPntVGNVPSvavSVPVP.....VPASASPKHGNTSSPK.H..GSSA.................ASSGKpSMS.AL................KSAanspssksssssssdsattPSKVKS......SSS....SSSSKDSSGRGDK.D......RR.........TSSVSSSGGSGSG........HQS...PktksSSSK....MKQleiiSPGSE....ATQ.VsSLQA.S......GGSTP.P..SG........QVDAA.
 1118- 1304 (187.72/45.59)	...SKSAIAA.QQARNR..........KSSLNAVIDK....LKNAQHCTET...........................daCGNG..GGNV....K....GSGS..................................S.......GLG..STGGM........SSTG...QKEKN.............IGSGGSSSSS..G.......................GK.TIG.E.......................................GGKS........CVT....KNASVDTKNPGEYMV......KHssdgikitiNKTRTKDSKQAAN........LKL...S....SSGSmaatSSS....SSLSS....VAS.S.SSSS.SsnvitgSNGSP.KthTGL.KPGVNSGPASKK
 1305- 1579 (219.33/54.58)	PQ.TLQATQKMLPTKMMlaaagmksaiSSSGATNTGSG.....AGITASATggvGG................NPLSKS..SSSKasGSP.....K....TSSGVTDLSRG.....R.........DKAriS.KSGDKGIFAskGLGDA..RKSSPSALR...EESES...ERAFKllaahASISNLPPSLP.PQLMME..GLMKqldtkfqipklsaranvADADK.NKS.SDklsilpdptkqtldglKQE...................QGKIAGlsnvtvSVS....KSSQPDDQS.............R.........R.....DHSQNKP........DNLsitT....SAAG....AMS....LNLGE....NTG.L.MLPPqS......TADSDvP..TNL.CIQPMVDNESSR
 1580- 1820 (195.17/47.71)	DScKDLGMRQ..................TSGQQFLGKIDDT.........S...VG......giltksnvsdQ..LTS..SGAK..SYGT....M....TSSNTSTASSGaivaeS.LnlstkpaDQA..VlQTKYNKI......TVEekKQQQTSSAS..LSSSSS...SSSSS.....SS....SIFSSLASVATSsdGNPV.................ITSD........................SGG...................GGGSGG......GGG....GGGEQEVVAAAAAAEmlldfsAA.........NKDSMTKGGHGLPasltqhhlTTI...P....ERAM....TQA....APTVRrntpPPP.P.PPPP.L......PAPFP.P..AASpSVSVHI.VKSPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.22|      84|     186|     151|     236|       3
---------------------------------------------------------------------------
  151-  236 (137.65/85.24)	VSPYDLIDEENRTydALNSDTIIKRKIGHSVTVCMEGSTG.HKLPTSSIITVNRSPTGKSTPSYAPLTSTNSS.MLPACFVLKLVKKM
  340-  425 (135.57/77.94)	VRPMARQDPEHTT..ILEVSALSWQHISVSVEHPYEETMAtAELDLTDISTLKCRLYGMSMTTNVEQTSDLSGrVLQRCLSIPLTMRM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27125 with Med1 domain of Kingdom Metazoa
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