<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27123

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMITPRPSNPPVGAPLRRTVEQRQAHGVVDIRAVVDVISTLEKTTVTKEALEITRLGKHINELRRKTSNEALAKRAKDLVRRWRDMVLPTVHSTSSQPTLALNGAKEMALRNLKPQSPALRELKPHSPLSLKDATPLRVLSPALSVHSDHSRSPNASSNNKQSITLTSNHRISSCSRNASPVLGTSNQNHVTEAVPRTHSSNKRLRKEESSKDQCQYYQSPLGTESTIEEVKKQRLNGENISGNLNSQVPSPTLKERISDCFAETSLETTNDESGPKKRGRKKGSKSAKRQSFLEDSVKEKLASISRNPKLKTTQELLADLQARGSNCSPIGSANALPSQSVAEPPSTEDVLRGNNEQVFKHLRCSSQKNSQSLHRSGLPSETSTGKTQKAARLRAAENCRESSSPESCQDRLREDDRISGTIETLTCRSPLQRDLTVEEILAKLPPLDPSSIDWGEEEERDDAECFPPPRDATAEDLERLHMQCIEGLNGNFQPRLSMATACSDGDERSNARDGGNGVSSRLSNMDSVKSVHNNQTDNVEFREWHQMLARPSYQGEILNIMPYVIID
Length567
PositionUnknown
OrganismAcromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Acromyrmex.
Aromaticity0.02
Grand average of hydropathy-0.840
Instability index66.98
Isoelectric point8.85
Molecular weight62736.40
Publications
PubMed=21719571

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP27123
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     206.50|      35|      83|     154|     188|       1
---------------------------------------------------------------------------
  107-  149 (33.40/12.58)	MALRN.LKpQSPALRE.LKPHSPLSlKDAtplrvlSPALSV.HSDH
  154-  188 (59.62/27.49)	NASSN.NK.QSITLTS.NHRISSCS.RNA......SPVLGT.SNQN
  196-  228 (41.26/17.05)	RTHSS.NK.RLRKEES.SK..DQCQ.YYQ......SP.LGTeSTIE
  239-  272 (43.86/18.53)	NISGNlNS.QVPSPTL.KERISDCF.AET......S..LET.TNDE
  283-  312 (28.35/ 9.71)	GSKSA.KR.QSFLEDSvKEKLASIS.RN........PKLKT.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.19|      20|      41|     405|     430|       2
---------------------------------------------------------------------------
  405-  430 (27.50/32.24)	PESCqDRLREDDRisgtiETLTCRSP
  449-  468 (39.69/25.04)	PSSI.DWGEEEER.....DDAECFPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.35|      23|      26|     472|     497|       3
---------------------------------------------------------------------------
  472-  497 (32.13/27.52)	ATAEDLERLHMQciEGLNGnFQPRLS
  501-  523 (41.23/22.70)	ACSDGDERSNAR..DGGNG.VSSRLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.50|      30|      40|     327|     366|       6
---------------------------------------------------------------------------
  327-  366 (41.42/40.16)	CSPIGSANALPSQSvaeppSTEDV.....LRGNNEqvfkhLRCSS
  369-  403 (46.08/22.83)	NSQSLHRSGLPSET.....STGKTqkaarLRAAEN.....CRESS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27123 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RLSMATACSDGDERSNARDGGNGVSSRLSNMDSVKSVHNNQT
2) VEEILAKLPPLDPSSIDWGEEEERDDAECFPPPRDAT
3) WRDMVLPTVHSTSSQPTLALNGAKEMALRNLKPQSPALRELKPHSPLSLKDATPLRVLSPALSVHSDHSRSPNASSNNKQSITLTSNHRISSCSRNASPVLGTSNQNHVTEAVPRTHSSNKRLRKEESSKDQCQYYQSPLGTESTIEEVKKQRLNGENISGNLNSQVPSPTLKERISDCFAETSLETTNDESGPKKRGRKKGSKSAKRQSFLEDSVKEKLASISRNPKLKTTQELLADLQARGSNCSPIGSANALPSQSVAEPPSTEDVLRGNNEQVFKHLRCSSQKNSQSLHRSGLPSETSTGKTQKAARLRAAENCRESSSPESCQDRLRED
495
437
82
536
473
415










Molecular Recognition Features






MoRF SequenceStartStop




NANANA