<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27118

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPVTNNIPQEGNRGGSISLGMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLYVRLLALVKWANSASKVDKSTERIVPPDPITPTEKRSTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVTFLIEQEFSVSLTVMGDGPTVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVVQSRLAESTNPLSEVYHILHYFCQSLQLEVLYSQTLRLIRDRLDDHIHVDEYTPGKCLSISYWRELTRKDPRSELGYRLTVQVDQHDPARPLAVVHIPSLGSKESEIAHRAIRSDQLSMECLLVHTIYVRTRSRLSELKQELQTMLKDVECTLAGSPAILSVPILQPCLRAELLLVTVDTHTGMLQCHVPQYDAPLVPELTMALNGDHSRLPTLISELRFWITQRRCEKTLQHLPATSHERLPVLHHPDHPMSKISRHRMFVQLHRHPTVILIVAFKEKESSPCEIECSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDSEVVETSNNKRRSTGIGGRTDAAGTPQNRRPKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLKLVQLPAPSPSIATSSAWHALLKRLLSVSIRVQGKGMAKTWTVEFVFYGSPLSSSHPKEQGLRRPVYFQYEMGTADTVSRTVDVLLNDWGQIVHLYLIVHDLAEYFKMEKYNLRNMVSIKSYSYSKLVLAYGPNQGATVTIQWSTNDKAFKMVFGRSPTNTVTNAHSIMKEQLEAHLNRYTNLAQIIHILNETLQPLTSISKLPSIPQLCVHARPRVPVQTFTIMPQCVTLVRIAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDENAVYRRRSQSEDDNPPSPVTMDSDGAGGNVSFLGHHRSGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTANISQASPKYIQLIANQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPASQSMASPAASNWPGSPSVPRPSPARPGQSPSHAALHSPQASDHKTGSHISRVLPQRSWAGAVPTLLTHEALEMLCCPSNHPSALPGPDMSPLERFLGCVYMRRQLQRFIQTEDCLTGINAEPGVVHFKSESLQCRVGLNPTHFQSLHIKVLSLPEYKDQWSLEELQIIEKFFDTRVAAPPYKHNTLSGFGRMLNVRFKVLKDFVQIMKLDLVPSLVQQQQLKWSVQLCLRIPPSAGPIVPPGTEGVHVCRSKILFFLQITRLGISYQGETPSLVLPFVHDVNTNITQLADRRDLTPPPSAIAAASMQLKRFAEYGANQSECSLFPAVRDLLANFTLPSEPPVISQVVPSPAGTQVASAQQIQNTAMQMHSPMAAGQGPPQGPGPYGIQGMQPMGMMGGPPQ
Length1485
PositionTail
OrganismAcromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Acromyrmex.
Aromaticity0.06
Grand average of hydropathy-0.261
Instability index59.31
Isoelectric point8.63
Molecular weight164871.19
Publications
PubMed=21719571

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27118
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     345.25|      53|      53|     921|     973|       1
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  921-  971 (88.19/39.86)	..........P.PSPVTMD........SD.....GAGGNVSF..LG.HHRS..GPQSPAQQREGLRFHP..PLTP.PSGS...N..PH
  972- 1025 (56.22/22.54)	TP.................asphtaniSQ.....ASPKYIQL..IAnQHQS..FGSSPATS.FNLA.SP..PSLP.PNTP...NmlPH
 1027- 1076 (57.72/23.35)	SPgsglvansP.LNPMHVP........SP......AG....L..MP.TSSP..GPCSNVQ..VG...H......S.PAGSfmqT..GH
 1077- 1120 (54.25/21.48)	ID......gsPfPASQSMA........SP.....AAS.............N..WPGSPSVPRPS....ParPGQS.PSHA...A..LH
 1379- 1425 (61.93/25.64)	TP........P.PSAIAAA........SM.....QLKRFAEY..GA.NQSE..CSLFPAVRDLLANFTL..PSEP.P...........
 1428- 1470 (26.93/ 6.68)	..............SQVVP........SPagtqvASAQQIQNtaMQ.MHSPmaAGQG...........P..PQGPgPYG.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.13|      51|      55|    1245|    1299|       2
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 1248- 1299 (82.48/51.74)	ELQIIEKFFDTRVAAPPYKHNTLSGFGRMLNV.RFKVLKdFVQIMKLDL.....VPSL
 1301- 1357 (79.65/39.64)	QQQQLKWSVQLCLRIPPSAGPIVPPGTEGVHVcRSKILF.FLQITRLGIsyqgeTPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.20|      56|     314|     106|     227|       3
---------------------------------------------------------------------------
  158-  221 (80.75/146.79)	GDGPTVPWRLLELEILVSDRETgdGKALVH.PLQTryvHQVVQSrLAESTNPLSEV.YHilHYFCQ
  403-  460 (95.45/37.37)	GDHSRLPTLISELRFWITQRRC..EKTLQHlPATS...HERLPV.LHHPDHPMSKIsRH..RMFVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     220.33|      63|     479|     222|     286|       6
---------------------------------------------------------------------------
  224-  286 (110.71/77.77)	QLEVL...YSQ..TLRLIRDRLDDHIHVDEYTPGKCLSI...SYWRELTRKDP...RSELGYRLTVQVDQHDPA
  668-  698 (20.52/ 6.63)	.................................GSPLSS...SHPKEQGLRRPvyfQYEMGTADTVS.......
  700-  768 (89.10/55.44)	TVDVLlndWGQivHLYLIVHDLAEYFKMEKYNLRNMVSIksySYSKLVLAYGP....NQ.GATVTIQWSTNDKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.11|      50|     273|     328|     381|       7
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  328-  381 (73.80/58.03)	TRSRLSelKQELQT.......MLKDVECTlAGSPAILSVPILQPCLRaELLLVTVDTH.TGM
  599-  656 (73.31/43.94)	TRREIA..HQGLQVeanatalVLKLVQLP.APSPSIATSSAWHALLK.RLLSVSIRVQgKGM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27118 with Med14 domain of Kingdom Metazoa
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