<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27117

Description CREB-binding protein
SequenceMPPLLMHPAYTNYGGGGSGNMQQIQAPPQQLHLQQHPLQHWNNIQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALETELRQHVQQQQQQLSHHLIQQQQGNKNLVANSLVMAAGTLGNKSPNMQSPPNVSVSKGGIVDPQMVVSLGNLPSSIASSLANNQMSIANSMGGLQSSMSMAGSNPAMSMPGGMNSGLVMTSTASGNNMGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMNTRAVAMQQQQQAHMIGPARGQSPHQQVHQVGIVGPGQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSQKSTPDPEKCRLIQQQLVLLLHAHKCQRRESQANGEMRQCTLPDCKTMKNVLNHMTNCQVGKTCTVPHCSMSRQIISHWKHCNRSDCPVCLPIKQANKNRTNSAQAPAIQPNNQPNTSPSEMRRAYEALGIQCPTTTPGILPGQGVGRGVRMPTPGMAGPPGALGNVRLAQPQTQAAPGQSVVGAGQQVVAPNVSLPLNSDPSTVGVAGNQTVPTTGPTSAAAAAAAHIQQSVNMQTLFGLNESGQPGVIGGENRLANLQLPGGLQPGQVTATPVQGTKEWHLSVTPDLRNHLVHKLVQAIFPTPDPQAMLDKRMHNLVAYARKVEGDMYEMANSRSEYYHLLAEKIYKIQKELDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPPNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMAIQQHNRMQFPQQQQAQQQQQAQQQQVQAQQQIQQQQQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGPQMSQANLTTTTASNNATTSQFPTSNGTTAGLPNSSPIQNQHQFPDLMKVRLAQAQAQAAQQQQQQQQQQQQSQQQPQPTSAPSQVGTPATSIPQTPSPFSGMQQPSAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVPVTTTGTTNGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPSPAGLASLGKGMTLQERAALNTPRSTSMSSQMAAITAALDRDNSPSPPMNNNKGKLDSIKEEIKMEIKQEPPDEPQNHRMDGKSVNNEIIIKTEPKTEPMEESSNEAIVKEEPGIKEESMTPVSSQDTTTSDIKPLVPEPIQPSGTSTDKKKCLFKPDELRQALMPTLEKLYRQDPESIPFRQPVDPQALGIPDYPTIVKKPMDLSTIKKKLDTEKYSDPWEYVDDVWMMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSGLLKGIGLLSDRYTFCQKCFNDIPGDTVTLGDDPTQPQTAIKKEQFQEMKNDHLELEPFVTCTDCGRRVHQICVLHMEAIWPLGFTCDNCLKKKGQKRKENKFNAKRLPVTKLGTYIETRVNNFLKKKEAGAGEVAIRVVASSDKVVEVKPGMRSRFVENGDMPGEFPYRAKALFAFEEVDGTDVCFFGMHVQEYGSECTPPNTRRVYIAYLDSVHFFRPRQFRTAVYHEILLGYLDYAKQLGYTMAHIWACPPSEGDDYIFHCHPAEQKIPKPKRLQEWYKKMLDKGMVERIVLDYKDILKQAMEDRLSSAADLPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAAANAIFSLSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAKIFATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPVINCDLMDGRDAFLTMARERHYEFSSLRRAKFSSMSMLYELHNQGQDKFVYTCNNCKSHVETRYHCTVCDDFDLCVSCKDKDGHPHPMEKLGFDLDDGSSPADAKQTNPQEARKLSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVMHTKNCKRKTNGGCPICKQLIALCCYHAKHCQETKCLVPFCSNIKHKIKQQQLQQRLQQAQLLRRRMAVMNTRPTGPVAMQTGQQTSNVAMTTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQVPHVSYTGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTASRYQSNTVMQQNPNLARQQTPQQLMQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNPPLMAAFIKQRALVHQQQPGQHGGGVGGPLGPNQPQQQQPGLQHMMSQQQQPQQQQPQQQTQQQQQQGRLQIQMLTQQAQQQQPVQAQSQWYKQQMLVMQQRQQQVAQQQQQQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPATMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
Length2587
PositionKinase
OrganismAcromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Acromyrmex.
Aromaticity0.04
Grand average of hydropathy-0.739
Instability index59.61
Isoelectric point9.10
Molecular weight282594.79
Publications
PubMed=21719571

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
histone acetyltransferase complex	GO:0000123	IEA:InterPro

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coactivator activity	GO:0003713	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27117
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     203.31|      15|      15|     820|     834|       1
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  742-  755 (29.13/ 6.87)	QLQAQQQQQ.QQQP.T
  820-  834 (29.97/ 7.31)	QQQAQQQQQAQQQQ.V
  837-  851 (30.35/ 7.51)	QQQIQQQQQQQQQG.I
  947-  960 (27.84/ 6.18)	QQQ.QQQSQQQPQP.T
 2330- 2344 (30.64/ 7.66)	QQQPQQQTQQQQQQ.G
 2383- 2395 (27.87/ 6.20)	AQQ..QQQQQQQQQ.Q
 2396- 2410 (27.51/ 6.01)	QQQ.QQQQQQQQQPfT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     150.13|      33|      47|     940|     986|       2
---------------------------------------------------------------------------
  855-  899 (35.04/ 7.58)	PPG........PSP.NGQSTsnanmvP.N........PGlspfgPQMS..........QANLTTT.TasnN.....AT.T
  974- 1022 (42.21/11.20)	PQT........PSPFSGMQQ......PsA........QQ.....PQQQpqqqsnqqfpTRPLSAT.T...PndngiATST
 1023- 1068 (35.73/ 7.93)	PQTipppassgPSPTGGV........P.VtttgttngPQ.....STT...........STPNTPL.V...P.....SLMT
 2497- 2525 (37.15/ 8.64)	..V........PSPRSG.........P.V........PS.....PHHH..........PPHGTPThS...P.....AHEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     330.12|      71|      73|    2030|    2100|       3
---------------------------------------------------------------------------
  529-  594 (58.59/14.02)	PT.......PGMA.........................GPPGA.LG...NVRLAQPQtQAA...PGQSV..VGAgqqvVAPNVSlplnsdPSTV.GVAGnQTVPTTGP...........
 2018- 2087 (110.90/33.27)	PFCSNIKHKI.KQ.........................QQLQQRLQ...QAQLLRRR.MAV...MNTRP..TGP....VAMQTG......QQTS.NVAM.TTGVAMKPGVSTSNLP..T
 2088- 2164 (109.63/32.80)	PHQPGIGLKPGTQ.........................TPPAHVLQvvkQVQEEAAR.QQV...PHVSY..TGK....VTPGGG......VGVGvGVGG.QTGGVMPPPQMQRPLPvqM
 2165- 2243 (51.00/11.23)	PNPSGTHLIPMDQwtasryqsntvmqqnpnlarqqtpqQLMQQQQQ...QQHQAQPG.MGMgaqMARQPgvIGP....VG.QVG......PQAS.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     252.16|      41|      43|     241|     282|       4
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  170-  206 (52.57/18.76)	SSIAS.SLAN.NQMSIANS..MG............G.....LQSSMSMAGSN....PAMSMP
  207-  230 (36.99/10.88)	GGMNSGLV.M.........................T.....STASGNNMG...G...M.AGG
  231-  272 (69.36/30.56)	SLIVTNSLNK.QPLNTVTM..MG............P.....NTQAIHHPGAPhGVTPMQNGP
  273-  316 (62.65/23.85)	GMMNTRAVAM.QQQQQAHM..IG............PargqsPHQQVHQVGI...VGPGQGGP
  317-  360 (30.59/ 7.65)	.....R...MqAPPNMANMptMGqlgasnpysygsP.....NTVG...PGA..GVTVCSNNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.45|      18|      18|    1175|    1192|       5
---------------------------------------------------------------------------
 1175- 1192 (32.45/16.15)	NEIIIKTEP..KTEPMEE.SS
 1193- 1213 (22.00/ 8.08)	NEAIVKEEPgiKEESMTPvSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.31|      10|      16|     459|     473|       7
---------------------------------------------------------------------------
  408-  425 ( 7.81/ 6.28)	QANgemRQCtlPDCktmK
 1988- 1997 (20.51/ 6.34)	KTN...GGC..PIC...K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      40|      48|    1792|    1837|       8
---------------------------------------------------------------------------
 1792- 1836 (59.91/63.08)	GNDlsAkiFATM..EKHKEvFFVIRLHSAQSAASLAPI..QDPDPVI....NC
 1841- 1888 (59.49/38.37)	GRD..A..FLTMarERHYE.FSSLRRAKFSSMSMLYELhnQGQDKFVytcnNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.75|      21|      47|    2309|    2329|       9
---------------------------------------------------------------------------
  914-  937 (28.04/ 7.92)	NSSPIQNQHQF..PDLMkvrLAQAQA
 2309- 2328 (36.79/13.22)	.NQPQQQQPGL..QHMM...SQQQQP
 2357- 2380 (27.92/ 7.84)	QQQPVQAQSQWykQQML..vMQQRQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.86|      43|      47|    1364|    1410|      10
---------------------------------------------------------------------------
 1363- 1409 (71.74/63.60)	TFN..PQVLCCYGKQlCTIPRDA.KYYSYQNsglLKGIGLLSDRYTFCQK
 1410- 1455 (70.13/48.45)	CFNdiPGDTVTLGDD.PTQPQTAiKKEQFQE...MKNDHLELEPFVTCTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.46|      15|      16|     459|     473|      11
---------------------------------------------------------------------------
  459-  473 (28.33/12.22)	NRSDCPVCLPIKQAN
  478-  492 (26.12/10.59)	NSAQAPAIQPNNQPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.20|      12|      39|    2440|    2452|      12
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 2440- 2452 (23.81/12.07)	PGLKpTPPPVPSP
 2469- 2480 (23.39/ 6.77)	QSVR.SPPPIRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     255.61|      67|      72|    1573|    1644|      13
---------------------------------------------------------------------------
 1529- 1569 (49.93/31.81)	........................RV....VASSDKVVEVKPGMRSRFVENGDMPGEFPYrAKA...........L.......FAFE
 1573- 1644 (118.63/112.31)	GTDVCFfgmHVqeYGSECTPPNTRRV...YIAYLDSVHFFRPRQFRTAVYHEILLGYLDY.AKQ...........LGYTMAHIWACP
 1648- 1715 (87.04/66.41)	GDDYIF...HC..HPAEQKIPKPKRLqewYKKMLD..........KGMV.ERIVLDYKDI.LKQamedrlssaadLPYFEGDFW..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.74|      13|      15|     766|     778|      14
---------------------------------------------------------------------------
  766-  778 (26.66/14.97)	RP..CAPPNVGTVMP
  782-  796 (20.09/ 8.72)	KPvgTVPPTLRSHSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.09|      21|      23|    1904|    1926|      15
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 1903- 1923 (39.58/15.13)	DFDLCV.......SCKD.KDGHPHPMEKL
 1926- 1947 (28.94/14.31)	DLDDGS.......SPADaKQTNPQEARKL
 1948- 1975 (29.57/ 8.61)	SIQRCIqslvhacQCRD.ANCRLPSCQKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.63|      15|      16|    1216|    1230|      16
---------------------------------------------------------------------------
 1216- 1230 (26.32/15.35)	TTTSDIKPLV.PEPIQ
 1234- 1249 (22.31/11.73)	TSTDKKKCLFkPDELR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.08|      30|      42|    1069|    1098|      17
---------------------------------------------------------------------------
 1069- 1098 (53.67/28.65)	PNQT.VSS..ASNQTPPHSGPTPSPAGLASLGK
 1111- 1143 (41.41/19.92)	PRSTsMSSqmAAITAALDRDNSPSPPMNNNKGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.91|      39|      70|       8|      62|      18
---------------------------------------------------------------------------
    8-   52 (61.74/51.70)	PAYTnygGGGSGnmQQIQAPPQQL..HLQQHP..LQHwNNIQK....RNYISN
   81-  127 (58.17/19.24)	PPAT...GPGPG..QQNGALETELrqHVQQQQqqLSH.HLIQQqqgnKNLVAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     113.00|      22|      74|    1258|    1279|      21
---------------------------------------------------------------------------
 1258- 1279 (40.85/26.86)	KLYRQDPE.....SIPFRQPVDP..QALG
 1281- 1297 (19.15/ 7.41)	....PDYP.....TI.VKKPMDL..STIK
 1298- 1318 (34.17/20.87)	KKLDTEKY.....SDPW.EYVDD..VWMM
 1331- 1355 (18.82/ 7.11)	RVYR....yctklSEVFEQEIDPvmQALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.45|      14|      23|    2539|    2553|      25
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 2539- 2553 (25.46/15.24)	GGPGAPTGHPATmPH
 2564- 2577 (26.98/11.43)	GGADANEVTPMT.PQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27117 with Med12 domain of Kingdom Metazoa
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