<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27116
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MASSRSTREVLLSLVDDIELIAKEMIENTIAQKPSKLSSTEHAQLTELLVAKDNELKATLKRAAEQAKINLKMEALKAEVERQDQDIQQLQRQLKEAEQILATAIYQAKQKLQSIARANKRPVPSEELIKYAHRISATNAICAPLTWQQGDPRRPYPTDLEMRVGFLGRLSDPSNLPLNGQLLGSHLGVPTDLHRAGHPAGEPPVSQSNQFAWHPSGEIHMSVGGQGSVAVNTHKQETEDVEVMSTDSSSSSSSDSQ |
Length | 257 |
Position | Middle |
Organism | Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea>
Formicidae> Myrmicinae> Acromyrmex.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.570 |
Instability index | 62.65 |
Isoelectric point | 5.93 |
Molecular weight | 28226.43 |
Publications | PubMed=21719571
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP27116
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 108.27| 29| 32| 120| 148| 1
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94- 113 (16.15/ 6.71) ...........LKEAEQILAT.AIYqAKQKLQ
120- 148 (54.08/38.62) KRPVPSE.EL.IKYAHRISATNAIC.APLTWQ
153- 181 (38.04/25.13) RRPYPTDlEMrVGFLGRLSDPSNL...PLNGQ
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