<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27110

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATDDSWKTSHFRQSVVAIIDEAIQVSGMPTTKNSIEMENHVFQKAKSKEEYLGFVARLILHVREMNSKKSATGNAPGTAGTNNQGMPDPIGALQTLARQGTGNNQMMSMGGPNHQGIISQPPTNTATNLLQSLNQRPAQPINMPGIQNKMPGMGMMPSQTGGPMNHMGPIQNMQNNPMLTQMNQMGQGNIPPQMNQMVPGQMGQLGAGQMQQNMQSQMQTQLPGQMNNQITGPMGNIQTSISQQMNQIGPGQLGPGQMQQQLNHIQRKPSEMMNTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPTRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYIEPLRRMIAKMSNEGNVDKLSKMKKLLEILSNPSKRMPLDTLLKCEVVLEKLDFKRGDSSVGPPVTTLKEHQIFSPLLEAVSAHLQSPVINHTLQRTFGPCLDALFGPEIKNLPPPLKKQKIEESSSEIPDVLQGEIARLDQRFKVSLDPAQQSGSRCIQLICWLDDRHLPCVPPISVTVPADYPSTPPRCVMAPHEYEATTFLCAVQKALNIRIAKLPRRFSLSQLLDTWEMSVRQASAPKEMSITASTVLMGL
Length633
PositionTail
OrganismAcromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus echinatior)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Acromyrmex.
Aromaticity0.03
Grand average of hydropathy-0.475
Instability index58.82
Isoelectric point9.34
Molecular weight68797.43
Publications
PubMed=21719571

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27110
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     179.30|      22|      23|     182|     203|       1
---------------------------------------------------------------------------
  138-  157 (31.96/10.47)	PAQ....PIN.MPGIQNKMPGMG.MM
  158-  177 (28.01/ 8.24)	PSQT.ggPMN.HMG....PIQNMQNN
  178-  199 (37.91/13.83)	P...mltQMN.QMGQGNIPPQMNQMV
  200-  215 (24.54/ 6.28)	PGQM......gQLGAG....QMQQNM
  256-  278 (27.93/ 8.19)	PGQM.qqQLN.HI.QRKPSEMMNTGF
  294-  313 (28.95/ 8.77)	PSPS...APS.PAGLG..APSSNQMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.10|      20|      22|     389|     408|       2
---------------------------------------------------------------------------
  389-  408 (31.93/22.99)	MSNEGNVDKLSKMKKLLEIL
  411-  430 (32.17/23.23)	PSKRMPLDTLLKCEVVLEKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      19|      20|     218|     236|       3
---------------------------------------------------------------------------
  218-  236 (37.65/16.60)	QMQTQLPGQMNNQITGPMG
  237-  255 (34.29/14.51)	NIQTSISQQMNQIGPGQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.91|      17|      22|     442|     463|       4
---------------------------------------------------------------------------
  442-  458 (29.57/23.42)	PVTTLKEHQIFSPLLEA
  466-  482 (32.34/14.14)	PVINHTLQRTFGPCLDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.76|      14|      20|     589|     602|       7
---------------------------------------------------------------------------
  589-  602 (23.12/16.67)	LNIRIAKLPRRFSL
  611-  624 (23.65/17.24)	MSVRQASAPKEMSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.36|      10|      30|     528|     537|      11
---------------------------------------------------------------------------
  528-  537 (19.62/11.31)	PAQQSGS..RCI
  559-  570 (15.74/ 7.59)	PADYPSTppRCV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27110 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNSKKSATGNAPGTAGTNNQGMPDPIGALQTLARQGTGNNQMMSMGGPNHQGIISQPPTNTATNLLQSLNQRPAQPINMPGIQNKMPGMGMMPSQTGGPMNHMGPIQNMQNNPMLTQMNQMGQGNIPPQMNQMVPGQMGQLGAGQMQQNMQSQMQTQLPGQMNNQITGPMGNIQTSISQQMNQIGPGQLGPGQMQQQLNHIQRKPSEMMNTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPTRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQ
66
374










Molecular Recognition Features






MoRF SequenceStartStop




NANANA