<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27097

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPLNNHHHNHNHNQQQQQQQQQHHSHRNTFNPTNLPINHHHYQQSNHNHNHHHNHNHLFFPSHPQSIQQAQQQQPSSQSLHHHQSQLLHQHSLHQHQQHIYLLQQPPPPPNLHHPHQPPPVPQSQPSHLPLHHHLPQAHHLQPTQSQLHHPLHHPHLALQSHPLLPVPHHLQLHPAYSQSQASHPQIHPLPLPQSRSGSFSSTSSQQHHPRTQPTPNSNLPVPPRPPHSNNYLRQSHGSTAGPSPSLLSSATFNSTPRHSLPPHNRPNLVPLPRSIDPRLARRTGSQSQNSQPSRLSLPSPSSVIAPIPIPPKPSTIQVPTSQPQSQPSTSQPPIITTTTATTTTTKVVRPTSASSADEQYQLGLAGPQAWGYMTTSSIEHNIWRGFSACKWKIPLVKQTQEIQEPFKEMVSEEMDEVEDRSPPILDHQWQIKWARVRCDSIENTSEFYLELDRLSLTYVTDSRTLQESWVYEIPGDLVPKKKSVAKEKEKESTDEDLSACDDGLRSTIDSLGFQYCKVIDQGILTYSSLFPTISERIKTTNAKPFIPYLSRPAKNITGNDFFAPTHLSAYIYFLEALQRYLFRIPLTSPLSSNPLNAIPTRWIPWGSDRLLSVPVMTDEPLRHALAMDSPRLLAAILHAPSSFELTLQGSCWLTPLAALCQPVFFARRLLPVPTETLIPDGFPLSLAPFPWLRARFVRMFGRLDLQCEPLERKSNPTSSTTAWISQHRKLAKLEEKRIGRFQEVWKRKMMIGKYQSAKNESPTSWLVCRLCEEEDDETGEEVVWPVCFALLDLESWLGRTEEPSLSETSFSTNEHDETDPLTHRLELSISRLEVAHRLLSSAAGSVQGLAESAGGYIDWLAQEREVQRKAVAAAAKGKEKENEEGVGGRCEGVLRSKSGFGPLLKLNSNTNANSNSHSNANANANANTSANANADANANANTNIGGILNHPGPLDINPQQSSFTSPPADPPSTRPVKRRHEDLEEEALISNDTNLTGPEEMEWCDNLPSERVLVEPFDRLSSSLPVSLGVDGLLEGNGVLSSPSPVALNTNLFATGSITTVSSGLPTSDDQTLLSTGLVGSSSSQLNTDIMLTSQHPSSSMEPATMMPRRPMVDPPGYESVCFGPAHSVNDVQYQDRKGKYALPPSPCSFGVGSDDDDELGSLSTLGEIEEERRRRLMETSRRLARESDPRAKFVKSKHTHNPSNHQRLSVHEPSYRISRSSLLALPTCHGQGITDFPPTPRSWVPLGSSNESLDDSSEGDDEDDELLGMVGEGVDGGQPGSSDSDSSSDNEDVEGKQSGVRMGSKEDKETIISNILKLEASLKKVLEFNLHQYKNPMNKVDQTKKKKKKKKEDRISSRTRDRLRNWASELGSQVIYDPGLESLIERLLPRKESLKSRWMNRTAKPEKSLSEGEIPRIERIEYHIPRIDDLKLGSHEEEEDGGGGGSNWKTLRATMVLVKTNLGQQKLGFPLSELKDWSKFGLEPVSGKRDVCVSVVLPRGKGSDRGRRRRERGRDADGRERDEEGREDEEEEEEEEEEEEEIRVMKRWLEKFSFAYNAGKFGQMTIGKVHRSEYSSTELSKEIEEMIESLDRVKSTRHACLIVIDKVEDFRGMMIGIRQIKGPDCRPVTRLMIDRQEFQDEEFSKMIKYSLRLYDSMKILVDRFRSPGISFETGTETSPNASQIQSSPSSSLLMRSRSESSCSSDSSISTIESGVDQFKILPKPIKRLSFGFAYYLNGFIKPLQLNLRWPANGIDVNSRHRFLHLSYKLLKSDEDQKEMVIVSLQDELGQEFEIRLKFMEHRYRREIRRRQKESNEKSKEIGLDQKDRLDLIVKVVWNEVGKVLVRSSVEWRVVIGKIGVMEPNEYKAWCELLSRKLPKSDLAFHVTLSSIRLDGLPLIRRRNLRSEIGFQTDLKEKVMIDSEEGEELEIVGNEKGGIEDKSNGIERVYDKESEGSYWIINESTIRTHSINLNYQSSEEEGSMNERIVKSLCTSMIYFEKGERFNGIRIEVLGTAASFHSVYSFNLFQHREEMNHSLIQLSKLRISRSLVFRNGAKDQAVPAHLFVIGFLDRVLGEYWGRIRSLAEDGDVEVDEDED
Length2099
PositionKinase
OrganismMelampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf rust fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Melampsoraceae> Melampsora.
Aromaticity0.06
Grand average of hydropathy-0.709
Instability index63.50
Isoelectric point6.27
Molecular weight236843.78
Publications
PubMed=21536894

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
chromatin binding	GO:0003682	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27097
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     323.47|      43|      44|      37|      79|       1
---------------------------------------------------------------------------
    5-   43 (46.37/15.43)	......NH.HHNHNH..............NQQQ.QQQQQQhhshrntfNPTNLP...INH.....H...H..YQ
   44-   85 (87.56/35.43)	QSNHNHNH.HHNHNHLFF...PS......HPQSIQQAQQQ........QPSSQS...L.H.....H...H..QS
   86-  142 (62.21/23.12)	QLLHQHSL.HQHQQHIYLlqqPPpppnlhHPHQPPPVPQS........QPSHLP...LHHhlpqaH...H..LQ
  145-  178 (38.49/11.61)	QSQLHHPL.HHPH..LAL...QS......HP.......................llpVPH.....HlqlHpaYS
  179-  213 (51.06/17.71)	QSQASHPQ.IHP...L.....P.......LPQS....RSG........SFSSTS.sqQHH.....P...R..TQ
  225-  260 (37.78/11.26)	RPPHSNNYlRQSHGSTAG...PS.......PSLLSSATFN........STPRHS....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.19|      17|      18|    1013|    1029|       2
---------------------------------------------------------------------------
 1013- 1029 (28.66/14.65)	V..LVEPFDRLSSSLPVSL
 1031- 1049 (22.61/ 9.86)	VdgLLEGNGVLSSPSPVAL
 1054- 1069 (19.92/ 7.73)	F..ATGSITTVSSGLPTS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.95|      14|      16|     660|     674|       4
---------------------------------------------------------------------------
  660-  674 (22.96/15.44)	LCqPVFFARRLLPVP
  678-  691 (25.99/13.04)	LI.PDGFPLSLAPFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.23|      72|     508|    1366|    1467|       5
---------------------------------------------------------------------------
 1366- 1450 (96.29/113.22)	RNWaSELGSQVIydPGLESL.IERLLPR.KESLKSRwmNRTAKPEKslSEGEipriERIEYhiPRIDDLKLGSHEEEEDGGGGGSNW
 1477- 1550 (115.94/61.79)	KDW.SKFGLEPV..SGKRDVcVSVVLPRgKGSDRGR..RRRERGRD..ADGR....ERDEE..GREDEEEEEEEEEEEEEIRVMKRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.78|      29|      38|     261|     294|       6
---------------------------------------------------------------------------
  268-  301 (40.64/21.22)	NLVPLPRSIDPRLARRTGSQSQnSQPSrlsLPsP
  304-  334 (52.14/17.72)	VIAPIPIPPKPSTIQVPTSQPQ.SQPS.tsQP.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.76|      13|      15|     539|     551|       7
---------------------------------------------------------------------------
  539-  551 (24.36/14.96)	KT.TNAKPFIP.YLS
  555-  569 (16.40/ 7.31)	KNiTGNDFFAPtHLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.96|      39|      40|     740|     779|       8
---------------------------------------------------------------------------
  714-  741 (25.40/ 9.85)	.............KS..NPTSSTTAWISQhrKLAKLEEKRIGR
  743-  781 (69.44/43.01)	QEVWKRKMMIGKYQS..AKNESPTSWLVC..RLCEEEDDETGE
  782-  819 (49.12/23.82)	EVVWPVCFALLDLESwlGRTEEP.SLSET..SFSTNEHDET..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.03|      12|      16|     501|     514|       9
---------------------------------------------------------------------------
  501-  514 (15.02/19.32)	C...DDGLrSTIDSLgF
  517-  531 (19.01/10.50)	CkviDQGI.LTYSSL.F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.46|      46|     391|    1567|    1619|      10
---------------------------------------------------------------------------
 1567- 1619 (64.67/70.04)	TIgKVH..RSEYSSTELSKEIEEMIesldrVKSTrHACLIVIDKVEDFRGMMIGI
 1966- 2013 (76.79/56.78)	TI.RTHsiNLNYQSSEEEGSMNERI.....VKSL.CTSMIYFEKGERFNGIRIEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.81|      15|     384|     481|     495|      11
---------------------------------------------------------------------------
  481-  495 (24.62/19.12)	KKKSV...AKEKEKESTD
  868-  885 (20.20/14.14)	QRKAVaaaAKGKEKENEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.29|      22|      22|    1197|    1218|      14
---------------------------------------------------------------------------
 1197- 1218 (40.81/25.34)	KSKHTHNPSNH.QRLSVHEPSYR
 1221- 1243 (36.48/21.71)	RSSLLALPTCHgQGITDFPPTPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27097 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELGSLSTLGEIEEERRRRLMETSRRLARESDPRAKFVKSKHTHNPSNHQRLSVHEPSYR
2) GPLLKLNSNTNANSNSHSNANANANANTSANANADANANANTNIGGILNHPGPLDINPQQSSFTSPPADPPSTRPVKRRHEDLEEEALISNDTNLTGPEEMEWCDNLPSE
3) GSDRGRRRRERGRDADGRERDEEGREDEEEEEEEEEEEE
4) MPLNNHHHNHNHNQQQQQQQQQHHSHRNTFNPTNLPINHHHYQQSNHNHNHHHNHNHLFFPSHPQSIQQAQQQQPSSQSLHHHQSQLLHQHSLHQHQQHIYLLQQPPPPPNLHHPHQPPPVPQSQPSHLPLHHHLPQAHHLQPTQSQLHHPLHHPHLALQSHPLLPVPHHLQLHPAYSQSQASHPQIHPLPLPQSRSGSFSSTSSQQHHPRTQPTPNSNLPVPPRPPHSNNYLRQSHGSTAGPSPSLLSSATFNSTPRHSLPPHNRPNLVPLPRSIDPRLARRTGSQSQNSQPSRLSLPSPSSVIAPIPIPPKPSTIQVPTSQPQSQPSTSQPPIITTTTATTTTTKVVRPTSASSADEQY
5) SQLNTDIMLTSQHPSSSMEPATMMPRRPMVDPPGYESVC
6) TCHGQGITDFPPTPRSWVPLGSSNESLDDSSEGDDEDDELLGMVGEGVDGGQPGSSDSDSSSDNEDVEGKQSGVRMGSKED
7) YKNPMNKVDQTKKKKKKKKEDRISSRTRDRL
1160
902
1504
1
1085
1229
1335
1218
1011
1542
361
1123
1309
1365










Molecular Recognition Features






MoRF SequenceStartStop




NANANA