<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27095

Description Uncharacterized protein
SequenceMAPKKMITRLNSITSSSNIETPKCPTDQDLRELGLNPYQLEPPNWRLPIQLNQPILGYPGLHPTHPGQQEDAITKSLVQSGFSARTLVGASIGSYRIHQTESFSAHQMIYKKLSDDSNFNLSSAGLSALIEARRRYCAINQYDTKSTIKIPGRVTLNDQKRENWLRELADPHVPLLKLSKNVPHGYKGEKLLEMLVQRRVEPVRAVWYIRLIGLNDIIAQRNKNDLMQIKYTITFTSELCQFLQKQLGEVTVPLQLNISSTTSLITGSSRLAGMNVRSKLRSSTLSDPETRKSWVAKFTHTTQILKRLYTDSLLDKPTLFKWLVDQLKLANLAQVHFLLDIHQLVVNKFCLSSNIVRGFVEASLSQIRVINKQRSTSYLSKLELRLKLAVQSSFIICADNFVWPDLWMPNRVLLESIIMSCTSGSDPDLDPLQQNISSVEVKEMLRNDFFSVDWRVSEMVGDLGVGTGPPGNTFTRRAQLVEILDGFSDYHDCSKLYYTYFLNPEPGEITTFKDRIEVLLSWSTTPFRTLDHRVFLTCNILACVKKDKKITVEEFQNHLIAWLEQVETNEGGDMLVRLFSELSRRSIFSYGAYIQRMVAKGDMEDDIMAGKSSGLQTLLREWMPMASTSKASRSGYNHLRRSPGRDAARNGLLSAFSDITISLAAPDYQQFFNTLNCQLEVSKPTSANRKMVTEILPDPVIRMVSDLSSFSSATSTTYHSRSNSPIQLASAVLLWAIQILESCKAYTTLYNVIHSVILRVLDGIDTYEQNSNEQTTSLSNSHIIQSRFCCLHVVCVAVMSSHRIFEIEGHLTGLISQMTNAYVRLRRFNSNAGSTIYLQFVRSFRALIMESRFPDGQILDLLNKDSNEFPAIALLDPNPESSSPITEDAMRFITRDIIQLLNEPSPEIASSLLSKIWEVYGHEPMGGPSIWNSFISGLDIFFRNESALDPSPDRFLQLRSTTRSTVLQFCEELNARSEGGLINCLVQGGTLPPVEIEESGLICDEGVQETARLTSEEGEEREEIDEPTPGHSELHVGPTLSPILQMLYLELVSIGVLSLETVLEEVILKPLIDLPESISRMMTSGEDKGETEKDQAVTRQKVLGHLSDIYDLTHALLLNHSPFEVGRVGSEAETPIGAYERTISGFVDGEARNYVEIFIDRSLSTWKLKSERYRWLEQSPAGPAFYSRLVLSLLLTMKGLLDLMKADDNDATMKEDVGQGEIIEDHPSPHVISSNRFLRELIESLERFRIMITCELAVIKRVINHRADLILDPLLEFLANNNTELAFNNNMVRTIDDLLPYSLPTDLVSYKYPYLESIFKSTCIFTHGARTRQFQLHLRLLLSGSPPQIDDKPPPTDVNSVLGPLVEVLARKLHLTDSKEPSPLFLSHLLPAVAEAVVIKLSAYLGISIFKLVTPSQQDPDYEISRIHHICRCITELTHQLTNRTFHMNGDVVAKSIGGTGQLMCNATLDSYLSYWNQLKNGITTFGGKFIENAYTDHNSGLKQSDSRTIRSLLHSIQVMLWALPGLVSHLGSVKFTISELLVDIAMCAQAQPSLMTQIMDTVGVLLFPSIPDDMALTSAVGVMRKRLRWLHIPISHLEAPCTDILPMDRLKYILGSSLRGTTTTFQERPKDGWVKLVEEKSWEELEKMDPVGPAFISIDALKCQTLSQVEVVPEGRRNTKNKMRSEQENVIRSATTDDSKTNDGMDENENNQGGQEDEDDEEDEEIVKGDRENFEHELNTDVLSTMPLHFLRSLYPSRSRLEGTYQVHAPINHMDLESARDHQTRLEIQTLKRLANEGMAMNSEPDEPNQSTSGSGGKTQVQTTPIHVPAPTRKRKIGQNELAAVHAEESILEPEDPSTHNGPTLRSTRSTRRKSTAIAPPPVPAPSNKRSKRR
Length1895
PositionKinase
OrganismMelampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf rust fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Melampsoraceae> Melampsora.
Aromaticity0.07
Grand average of hydropathy-0.284
Instability index51.23
Isoelectric point5.84
Molecular weight213121.60
Publications
PubMed=21536894

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27095
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     407.72|     131|     214|    1276|    1420|       1
---------------------------------------------------------------------------
 1276- 1420 (200.37/149.07)	EFLANNNTE..LAFNNNMVRTIDDLLP......YSLPtDLVSykypYLESI.FKSTCIFTHGARTRQFQ..LHLRLLLSGSPPQIDDKPPPTDVNSVLGPLVEVLaRKLHLTDSKEPSPlfLSHLLPavaeavVIKLSAYLGISIFKLVTPSQQDP
 1489- 1630 (207.35/121.54)	KFIENAYTDhnSGLKQSDSRTIRSLLHsiqvmlWALP.GLVS....HLGSVkFTISELLVDIAMCAQAQpsLMTQIMDTVGVLLFPSIPDDMALTSAVGVMRKRL.RWLHIPISHLEAP..CTDILP......MDRLKYILGSSLRGTTTTFQERP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.04|      37|     214|     896|     958|       2
---------------------------------------------------------------------------
  857-  894 (56.50/22.06)	QILDLLNK...................DSNEFpAIALLDPNPE..SSSPITEDAM..RFIT
  896-  936 (56.81/35.55)	DIIQLLNE...................PSPEI.ASSLLSKIWEvyGHEPMGGPSIwnSFIS
  965- 1001 ( 6.73/20.17)	TVLQFCEElnarsegglinclvqggtlPPVEI.EESGL.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.57|      21|      53|    1816|    1836|       7
---------------------------------------------------------------------------
 1816- 1836 (39.75/23.84)	SGGKTQVQTT...PIHVPAPTRKR
 1868- 1891 (34.81/19.90)	STRSTRRKSTaiaPPPVPAPSNKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     391.28|     131|     544|     545|     689|       8
---------------------------------------------------------------------------
  545-  689 (196.22/154.57)	KKDKKITVEEFQNHL..IAWLEQ.VETNEGGDMLVRLFSElSRRSIfsyGAYiQRMVA...KGDMED..DIMAGKSSGLQTLLREWMPMASTSKASRSGYNHLRRSpgRDAARNGLLsafsDItisLAAPDYQQFFNTLNCQLEV..SKPT....SANR
 1092- 1236 (195.06/117.62)	EKDQAVTRQKVLGHLsdIYDLTHaLLLNHSPFEVGRVGSE.AETPI...GAY.ERTISgfvDGEARNyvEIFIDRSLSTWKLKSERYRWLEQSPAGPAFYSRLVLS..LLLTMKGLL....DL...MKADDNDATMKEDVGQGEIieDHPSphviSSNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.35|      37|     215|     278|     316|       9
---------------------------------------------------------------------------
  278-  316 (54.65/47.73)	SKLRSSTLSDPETRKswVAKFTHTTQILKRLYTDSL..LDK
  494-  532 (59.70/43.21)	SKLYYTYFLNPEPGE..ITTFKDRIEVLLSWSTTPFrtLDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.18|      21|     715|    1004|    1024|      12
---------------------------------------------------------------------------
 1004- 1024 (34.43/21.93)	DEGVQETARLTSEEGEEREEI
 1707- 1727 (36.76/23.95)	DENENNQGGQEDEDDEEDEEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27095 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TMPLHFLRSLYPSRSRLEGTYQVHAPINHMDLESARDHQTRLEIQTLKRLANEGMAMNSEPDEPNQSTSGSGGKTQVQTTPIHVPAPTRKRKIGQNELAAVHAEESILEPEDPSTHNGPTLRSTRSTRRKSTAIAPPPVPAPSNKRSKRR
2) VEVVPEGRRNTKNKMRSEQENVIRSATTDDSKTNDGMDENENNQGGQEDEDDEEDEEIVKGDRENFEHELNTDVL
3) VQETARLTSEEGEEREEIDEPTPGHSELHV
1746
1670
1007
1895
1744
1036










Molecular Recognition Features






MoRF SequenceStartStop




1) EESILE
2) NKRSKRR
1849
1889
1854
1895