<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27084
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNRKTLQPTGSKSVSTHQSLLQSLDQLKLPISPNKTEPIQNQFQSFLKSYQTLSHSIFHQISTNNTIPNQTPQKLLNDLNQLDQYLVKLLSFHATHDSNCKRMNRLMNQIQIINQNKLNQNIQKIYDAEKKLNSICLNGEKEKQSYRKIDSLSLKPTQILNHAKLIAPYTSAPPAPPTTNPNNTTVATAGLDLQDPALRFLMPFPTEDIIRRGRMGQEMSGTDPSEIDKLAGNQLGPVVGETRSASGVRPSVVAKSQVVYPTMSSRRPPPPEVEEDLFDLDLNPDL |
Length | 286 |
Position | Middle |
Organism | Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf rust fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina>
Pucciniomycetes> Pucciniales> Melampsoraceae> Melampsora.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.636 |
Instability index | 51.61 |
Isoelectric point | 9.11 |
Molecular weight | 32016.03 |
Publications | PubMed=21536894
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP27084
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.01| 27| 34| 74| 100| 1
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74- 100 (45.96/27.08) KLLNDL.....NQLDQYLVKLLSFHATHDSNC
105- 136 (33.05/17.69) RLMNQIqiinqNKLNQNIQKIYDAEKKLNSIC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 73.50| 24| 32| 17| 40| 2
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17- 40 (41.78/25.83) H.QSLLQSLDQLK....LPISPNKTEPIQ
42- 70 (31.72/17.81) QfQSFLKSYQTLShsifHQISTNNTIPNQ
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