<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27079
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MEAAKRQQQQQQQQQQLQLQQQQQLQQQQQQQQQQHQLLQQQLLKRQIKDTVTNNIFEFHMKCKSLFEAFNQITGGTQQQQQLQQQQQQNLQIQQPLQRLVDVDKIYQKSLKQLEQHLIYQKEIVDIQKEIIEKDKVIMEMATTLKSLEKTLEEDIEEYGAKKTKGDEREVYPEDLISYAHKISGTTSAPFGYQPHLALIPLYKPPAPQEEMMRASVLFQKLPLNLLRFYGLAEKDLVVPLATPPSMSSTSAKEGDTNISPALLASSSTTLDTIPPIGSMEKDLLGQSRDSNNSNNTETQLPTLQPIVQITTPPTRQPQLIPATIDLDLNPDMDDSDDDDDDDEESDEASENEEVEWD |
Length | 358 |
Position | Middle |
Organism | Cavenderia fasciculata (strain SH3) (Slime mold) (Dictyostelium fasciculatum) |
Kingdom | Amoebozoa |
Lineage | Eukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Acytosteliales>
Cavenderiaceae> Cavenderia.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.867 |
Instability index | 64.80 |
Isoelectric point | 4.54 |
Molecular weight | 41006.33 |
Publications | PubMed=21757610
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP27079
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 107.85| 17| 18| 7| 23| 1
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7- 23 (36.71/12.72) QQQQQQQQQQLQLQQQQ
26- 42 (36.67/12.70) QQQQQQQQQQHQLLQQQ
79- 95 (34.46/11.53) QQQQLQQQQQQNLQIQQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 126.27| 42| 44| 249| 292| 3
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249- 292 (61.41/45.57) STSAKEGDTNISPALLASSSTT..LDTIPpiGSMEKDLLGQSRDSN
294- 337 (64.86/41.34) SNNTETQLPTLQPIVQITTPPTrqPQLIP..ATIDLDLNPDMDDSD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.86| 16| 38| 191| 206| 4
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191- 206 (31.59/20.46) FGYQPHLALIPLYKPP
230- 245 (28.27/17.61) YGLAEKDLVVPLATPP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.57| 12| 18| 154| 166| 6
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154- 166 (16.88/16.50) EDIEEYgAKKTKG
174- 185 (21.69/14.78) EDLISY.AHKISG
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