<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27077

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNDHNHQPSAAGGSGGSSSSPTAGLPIATPAATTNNTTTISLSVVIHRLVEQSYNNLMSLTERLPKESDIERKKQLVDYLDATREKFLKLLVLLKWSQHVSTLTKANEIIEMLNKEDNYFRDAADHLMMTKDAMINARAPIYDVPTAIDVLTTGSYQRMPTNIKRVLPPAPPLPAQIQSTIEKLNSILRYKLFTLDIPKEFDPIKVEDGKAHIKVENEYECFLSIDGGSDKSNWILLSFNLFIYSQKDREGEGPIKVAYDDKMKQVQDRIQARIVTSNQPLYELHNMLHYLVVSSQLSILCAQSENLKKTILKNSTRCIFGKDVKDQSITVFYWIPEELANTFDHKKPNIYIKIAIDPDTQKLIISHVPSLTHPNIPNYTFNVASLNLENILFSAIELHGYLRLQKLNVILYEERLKQQVKSFDDIKLIGSCGFENSSVVSSTDQKQMIDDESLAATLFIKLYGSNNHLDVSVNFQNGKYTLYHSTLKNRDLLLNLETRLNNDNMEIKSIVNFFRLKSLLSCIEEAAVFMEMECFYKIPIQNDILIQTLLESNGQYICIRFSNENEIFYLFVTIQNTSTTTNSSSVFTPSIFLFNNNNNNNSSQPTIFKMDSDEELTSLIQQQPSNTTEQNTKFQKQINNILYRLVESAKKKIKILQASLLLSKENIAHTIIPQPSSSSSLTESMQHETISFLYQPNNSVIQTNKMYLSFYGNDSDQSHQQYCTISFYDKSPLVFMNDQVDQSNTTQQQRHPASFVQNDHISHSLSGLWTFTYSTFSNNNWLNSFQNDIQSVNKMLSLSMQMIKQLNSTPKLSLIFHIDHIAPLELKLTCTNINTPNDLKHTIRIYVNQSKNYSIEYQPFVNPLVPFYERILNYNNTISTNTTITTITTTNNNNNTANTSPSNTTPTTSAPPTMATKINDQTPNSILNFLNSIAISNEMVYAVQSLIYPSTTTYFPPLETVIIPRNSTHIRLVYRNQHALDVRAVTTEHCIVEDAYFSTASLLSSQQSQTQKKLLSPIPSLHQVMEQRLGHPSMDNPLGQRTSWLVPLKTLKSTVHNILCFLNYHYLVKNFASLIKNHYKDAQYAPNQLKFVNENVSVIVQVREYIQVDMEATNTRPDSSPSKFELDTLSIFFKKNTQLSYRTQTIISLVNFFTLPIKVWIELCKIIRSGINEPEDNKPKYNMELLLNTSNLHPREALIHLKDRQILMLIVRFFSKQQEIYVDFPLLYDYQNATVRYWNKTMPTSINAEQQQQQQQPPTGESQNKKMMAINNLTDLVDFTNSLKSSQAPLYMFCQKLSYHIDHLFPTTTTTTTTSTTSIPVVTNPQSVTIPINNVSLPTQPTFNAPLTSVIT
Length1352
PositionTail
OrganismCavenderia fasciculata (strain SH3) (Slime mold) (Dictyostelium fasciculatum)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Acytosteliales> Cavenderiaceae> Cavenderia.
Aromaticity0.09
Grand average of hydropathy-0.344
Instability index44.61
Isoelectric point6.84
Molecular weight154256.64
Publications
PubMed=21757610

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27077
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1088.33|     320|     367|     458|     823|       1
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  442-  750 (377.17/287.81)	...........................................................STD........QKQMIDDESLAATLFIKL.Y......GSN.......NH.LDVS.VNFQNGKYTLYHSTLKNRdlLLNLETRLNNDNMEIKSIVNFFRL............KSLLSCIEEAAVFMEMEcfykipiqndILIQT...........LLESNGQYICIR.FSNENEI...FYLFVTIQNTSTTTNsssvftpsiflfNNNNNNNSSQPTIFKMDSDEElTSLIQQQPSNTTEQNTKFQKQINNILYRLVESAkKKIKI.......LQASLLLSK.....ENIAHTIIPQ..PSSSSSLTESmqHETISFLYQPNNSV....IQTNKM.....YLSFYG.NDSDQSHQQYctiSFYdkSPLVFMNDQVDqsnttqqQR
  751- 1028 (353.38/214.21)	HPAsfvQNDHISHSLSglWTFTYSTFSN..NNWLnSFQNDIQSVNKMLSLSMQMIKQLNSTP........KLSLIFHIDHIAPLELKL.T......CTNintpndlKHtIRIY.VN.QSKNYSIEYQPFVNP..LVPFYERILNYNNTIST........................................................................................NTTITTITTTNN............NNNTANTSPSNT..........TPTTSAPPTMATKINDQTPNSILNFL....NS....IAIsnemvyaVQ.SLIYPStttyfPPLETVIIPR..NST.........H..IRLVYRNQHALdvraVTTEHCivedaYFSTASlLSSQQSQTQK...KLL..SPIPSLHQVME.......QR
 1031- 1337 (357.78/198.92)	HPS...MDNPLGQRTS..WLVPLKTLKStvHNIL.CFLNYHYLVKNFASLIKNHYKDAQYAPnqlkfvneNVSVIVQVR.........eYiqvdmeATN.......TR.PDSSpSKFELDTLSIFFK..KN........TQLSYRTQTIISLVNFFTLpikvwielckiiRSGINEPEDNKPKYNME..........LLLNTsnlhprealihLKDRQILMLIVRfFSKQQEIyvdFPLLYDYQNATVRYW..................NKTMPTSINAEQQQQ.....QQQPPTGESQNKKMM.AINN.LTDLVDFT.NSLKS.......SQAPLYMFC.....QKLSYHI.DHlfPTTTTTTTTS..TTSIPVVTNPQSVT....IPINNV.....SL...........................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.94|      69|     100|     207|     282|       2
---------------------------------------------------------------------------
  207-  282 (97.78/89.27)	EDGKAHIkVENEYECFLSIDgGSDKS....NWILLSF.NLFiySQKDREGEgpIKVAYD.DKMKQVQDRIQArIVTSNQPLY
  305-  379 (109.16/70.49)	ENLKKTI.LKNSTRCIFGKD.VKDQSitvfYWIPEELaNTF..DHKKPNIY..IKIAIDpDTQKLIISHVPS.LTHPNIPNY
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.46|      41|     221|     162|     205|       4
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  162-  205 (62.09/57.34)	NIKRVLPPAPPLPAQIQstIEKLNSILRYKLFTLDIpKEFDPIK
  387-  427 (68.36/49.75)	NLENILFSAIELHGYLR..LQKLNVILYEERLKQQV.KSFDDIK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27077 with Med14 domain of Kingdom Amoebozoa
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