<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27076

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMKLHLSQKNDFRENFDQKRREMTENITTISAFPPPPPFYKLYVHYNANTAATTGTGGSSSSNNSAVPSPAMPPVAQSSMSGGGSGGTVSPMLPPPPLLPAPLPPPLPPQQGSTYVQFGQNYATTDVLPPLGEETPQLYPAGDIEPIKELKKLNRSILFNYLQLLETLIENPSTYKTKVDDISLLFINFHHLLNSYRPHQARETLISIMTEQCNQKKLNIEKLNNSLEQAKQILRETLNAIIQKPIDQQPTINNVNQTNNNINNNNPFSPPPLSISSHLPGSTTNLHLQSSSSTNQQQQQQQQQQQQQQDGCNPNWVSNYLNLLSEIPRV
Length329
PositionMiddle
OrganismCavenderia fasciculata (strain SH3) (Slime mold) (Dictyostelium fasciculatum)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Acytosteliales> Cavenderiaceae> Cavenderia.
Aromaticity0.06
Grand average of hydropathy-0.675
Instability index71.37
Isoelectric point6.66
Molecular weight36565.62
Publications
PubMed=21757610

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27076
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.56|      24|      24|      50|      73|       1
---------------------------------------------------------------------------
   50-   73 (42.47/21.16)	AATTGTGGSSSSNNSAV..PSPAMP.P
   75-  101 (36.32/17.05)	AQSSMSGGGSGGTVSPMlpPPPLLPaP
  107-  129 (39.77/19.36)	PPQQGSTYVQFGQNYAT...TDVLP.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.17|      20|      67|     148|     167|       2
---------------------------------------------------------------------------
  148-  167 (34.00/23.02)	ELKKLNR.SILF.NYLQLL.........ETL
  174-  204 (18.18/ 9.19)	YKTKVDDiSLLFiNFHHLLnsyrphqarETL
  218-  237 (25.99/16.02)	NIEKLNN.S.LE.QAKQIL........rETL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27076 with Med7 domain of Kingdom Amoebozoa
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