<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27073

Description Uncharacterized protein
SequenceMTGSQRQGPHRSNTNTSEHSLGRIQQHQSLNNTANNISESTFINNSQLASSLAYPNPLLGLSQFRDRPDSRQQMQSAMLDDSDVTAISTASQRNPYPMTGSAQRLRQMPQFQPMLQSGVQQHIQLSQSGSSVSMQAAHAPQLNPKLQPQILQPQLLQHIQQQQFLQQQQHQNLFQQQHQEPSQQHLKRFQKQNITPPLFVSDSSVHGLKPLHKYEYRLPSDRLLSRSGGSDYVDVYLQRHGQPEDKLDETTVKAGYTDKSPVQNETLSVFESIHIYDHLSRKNVFQDMVKFASTVLAAQSQVTFPKESQFTISRRTGTSSKTYDNWIDDLFGNIPFSELSKSVPFGLKLDKLLESLQQKQVSLVRATWAIKMIGVTDLASSSRLSRVDSHLDASFSWTSIVIAYIQKQINEVSLSAVNTPQISQVRNQKRTQSKEAIAAAAEAAASKHISPKQRHHFISRWDYLMRLCAKQYEEGLLDQGSFLKKSLEIFKMCNFSQTMFAVTLISMFVLEIGRSRALMRLLVSICLKKLKKLKLHISTSDFAKEQYNQLVILLQRGYRCAPDTFVSTKLWVNFEEFLTVVFADEHQTRMEVESRNNWLISSAPLTLCASESLNVLFRTLGYWTNYSQIYQTWDAFFDGFTDISIHLRHIFNWALADSRPSQDSRAFIAARLVSEWYKNMLNDNLTKKNHHSLLSMNFAKLFYKLLDKLIATLPSGQDEQHRLFLLFSQLEQLRVFSIRQYAQRLVSRGDLDSSSNTSEKFKCFLQGYPLRIAELVQNCQLYHKNDVNLANDSDNDFCIQSVLELIVRTDTESRKQDVLHFENIKKQIIAVLPRIYISGDKVDTLRDRLVQDMPKDRALAWPNMKLKQNLISLVPIWRIRLSIWLKKCVVQFIVKAQEIGINNWKTVSTPGNSTLNDRQLATVIWILETLRDYPSLLEILMWLINKTTERNIYRSIVFALERHQLVFHAMGCSQLIFDHLFEKHQTLRKRGTGLDPHILRHLFSLLTHKLCEMDFEERKKLESDRALPLKRGTSKEIPLEFRDLRDAKDDRQSITNAASSLIWRFQDMREALARLFKYSLILLSRQSSIMQKDDFRRRVTLTVEVLREVADRNPSLQASIIDHYRDTYVTSKPFTVMTPGTELLGGIDNMASTWSISMIVQLITSRCCPLQRFLDEVVDPIISRAKANIDLLKSVYFTNLISNMVYLLSVICISTESVSLTPQLILTLQQYQYLERLRVVDMHTPAYLSRILHILQSLAFIRSRLTSTSAAVDIASNEQLLSGIQVLLTYVLERPGWFKHACITDQSWISFDLARLFTDAKNLFSQDTLALDMVLQSTHVVFKALWDTHTFDGYTENTVEAPFNINAFETCFERICRHSNACNRDRCQYLLTLTLELLHLHQSIHASGVTAVSSFSQSVSVDSIAASRQNMAEAYSKCWDRLVDVCFKEVLGRNSTSLSHLLPKMRWEFLKRLVVRSQQLMESVHSLLSTTPLKEFNLAGTNIALDADSQQHLVVNTASIKCFGEFTSKLGVYMCHRLKEVRKAKSSGKTAAKQTEDAYLADISVLAAFILRDLLWFQENIKVFDLMVDNEISFGKAHQLSTAVSSTDLPPSQLQDQVMLAQIQEILIARLTLVKTLAPVIMENPIRFQIVLLAQSLMKLLVSKLVTNTIGTSHLFQITLDVVSWFMEEIPKDLSKGLFAWLVKNRQEFSLPSPAGDRVNRILPFVDRNRLVSNLIFRSSGFNESLHELGTATSSSASSTPIWKPSQVSASVSTQSTGMSASITSPTPSASNTPHLARAPIVTSDSKHSTKPASFLKVDQHYFLPWKWLEDPGDVVLQQQPPAPSMCWANPNTIAPLNNTPISLTSFGAKVLHPMEPAYIQLHKQGWTLPDVGSRVSDNTALMELTNFSDEESVVEVVMTSSTVTAASTQPTPVAHVDMPQHTTFDAMDIDVNPNHQAGIMDVKIHSGSLKPAVTKGSRIPTKRKSTDTTTTGITKAIKKHN
Length2002
PositionKinase
OrganismBatrachochytrium dendrobatidis (strain JAM81 / FGSC 10211) (Frog chytrid fungus)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Chytridiomycetes> Rhizophydiales> Rhizophydiales incertae sedis> Batrachochytrium.
Aromaticity0.08
Grand average of hydropathy-0.232
Instability index45.20
Isoelectric point9.02
Molecular weight227359.86
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27073
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     356.80|      92|     143|     193|     314|       1
---------------------------------------------------------------------------
  193-  284 (155.16/96.42)	NITPPLFVS..DSSVHGLKP....LHKYEYRLPSDRL.LSR.S.......GGSDYVDV..YLQRHGQPEDKLDE....TTVKAGYTDKSPVQNETLSVFESIHIYDHLSRKNV
  333-  431 (116.74/109.59)	NI.PFSELS..KSVPFGLK.....LDKLLESLQQKQVsLVR.AtwaikmiGVTDLASS....SRLSRVDSHLDAsfswTSIVIAYIQKQ.INEVSLSAVNTPQISQVRNQKRT
 1858- 1937 (84.90/43.10)	NNTPISLTSfgAKVLHPMEPayiqLHKQGWTLPD..V.GSRvS.......DNTALMELtnFSDEESVVEVVMTS....STVTAASTQPTPVAHV...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     326.52|     107|     143|    1439|    1580|       2
---------------------------------------------------------------------------
 1439- 1548 (168.38/100.87)	WDRLVD..VCFKEVlGRNSTSLSHL.LPKMRWEfLKRLVVRSQQLMESVHSLLST.TPLKEFNLAGTNIALDADSQQHLVVN...TASIKCFGEFTSKLGVyMCHRLKEVRKAKSSG
 1584- 1697 (158.15/93.20)	FDLMVDneISFGKA.HQLSTAVSSTdLPPSQLQ.DQVMLAQIQEILIARLTLVKTlAPVIMENPIRFQIVLLAQSLMKLLVSklvTNTIGTSHLFQITLDV.VSWFMEEIPKDLSKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.88|      18|     143|     297|     314|       3
---------------------------------------------------------------------------
  297-  314 (31.72/18.09)	AAQSQVTFPKESQFTISR
  443-  460 (33.16/19.25)	AAASKHISPKQRHHFISR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.41|      31|     143|    1247|    1279|       5
---------------------------------------------------------------------------
 1247- 1279 (47.68/33.48)	YL....SRILHILQSL.....AFIRSrlTSTSAAVD.IASNEQ
 1389- 1429 (36.74/19.44)	YLltltLELLHLHQSIhasgvTAVSS..FSQSVSVDsIAASRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.61|      32|      34|      91|     124|      11
---------------------------------------------------------------------------
   55-   83 (43.41/24.14)	....PNPLLGL.....SQ.FRDR.PDSRQ.QMQSAMLDDSD
   91-  124 (57.64/42.42)	SQrnPYPMTGS.....AQRLRQM.PQFQP.MLQSGVQQHIQ
  126-  160 (34.56/17.91)	SQ......SGSsvsmqAAHAPQLnPKLQPqILQPQLLQHIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.18|      51|     239|    1072|    1136|      12
---------------------------------------------------------------------------
 1072- 1136 (68.64/77.75)	LARLFKYSLILLSrqssimqKDDFRRRVTL..TVEVLREVADRNpslqasIIDHYRDTYVTSkPFTV
 1313- 1365 (84.55/57.06)	LARLFTDAKNLFS.......QDTLALDMVLqsTHVVFKALWDTH......TFDGYTENTVEA.PFNI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27073 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HIQLSQSGSSVSMQAAHAPQLNPKLQPQILQP
2) KPAVTKGSRIPTKRKSTDTTTTGITKAIKKHN
3) MTGSQRQGPHRSNTNTSEHSLGRIQQHQSLNNTANNISESTF
4) MTSSTVTAASTQPTPVAHVDMPQHTTFDAMDIDV
5) TQSTGMSASITSPTPSASNTPHLARAPIVTS
6) YPNPLLGLSQFRDRPDSRQQMQSAMLDDSDVTAISTASQRNPYPMTGSAQRLRQMPQFQPMLQSGVQ
122
1971
1
1919
1774
54
153
2002
42
1952
1804
120










Molecular Recognition Features






MoRF SequenceStartStop




NANANA