<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27039

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDAVPLRLLVDMIVQRAYKDLADMTETVAPARQRQQELMRYLHEARQRFMRLLVILRWLSKSGQADNVATLVQATHMKHLTVLETANALHGHVESMAMATLPSYDVPHAVDVLGSGEYPRMPRNIELLLPEPPLLKSDVDRALSWLHMQIRGRLADEPAPRGLSAVTIGKGRLTLTCGGLYSMAFTIDNNSATSPWRLLTVDVFVRDEWRLDAHAAPASCERLVTSPHIERLRRLLKGILDTTRDQPLSRCCAAIHTFCLSLQLNTMAAQAEALQRTKWGSSVVVDASSSPSSLKLSFWPEFKRLVSRVESYDELDGNQSSSPPSSSSSSSSSSSWLALVKAAAGAAPPPGSTQPASQSSSRGGGVEGWASATLEIVSPLRPQTPTTGSKQARGHHANHNHANRTSDDSGDNSGGVDEGANNEAMPPVYDSFDFYIDVKPTPVVGMDGSDYDACMGRSPNMQALLTCVQRRLSHHLLASIREQLAASALVASCAAMVSFGPAPQDPTTPTAATTTTATTTAAAAATQPLSLWRMGTRSEGRSGGVMDTRWHDVADDDGGAGNNDDDVADDAMCVNVTFPIRVEATAASAAAAAMKSGDAEDSGPSLGTTSSPSSPDVTALETLTPTEERLSLRVCPDSGRLFLTTCLQATDLHAVEQAINFDPLQAPSCMHAAMRTCVLDAVIRRIASSSFATEVKMTSLGGLSHVLDADTLAFSRCFIFLDYPGHALLLSVSASLSMRVRMLACHIEAPYEVAASFPGHTATSPHMSSSSSVATAMLATNAKTNSARAGSTSSPASGGGGMTPSSSTSLGLSAPSRGNTPAQTPTSAGATHSSLAPSSTTAPAPAVLRVYDSARAVVASALRMSTCEMRQAEGRRWDRICQAAEMEGALRVDTVMDILVDKHQHQHQHQQQQQGLADARFNWSELEQRRLQRQLAVTRFAMLLSCVSRQLRSDSLRHSPLISLSDAQSWSLLETGVTFRIFNLATSPLVPLKSAHLHCAASGICRWQIAMDTSRLPSWLHQRQTVADNDSLALKGRFDWAAGTFTATSLTPAGCLDALQRPWYSHMKFLQTVCMLRDESLPHHKLLSLHSFGADGLEIGVHWKPNADKVVPTSSSTAAAAGATAGAGAGGGGGGDTNVNSSSAVLGDALTTTTSVAIDAATAAASATSGHDGVLGNITTAGLPTSGSAVSPAPPSPPAEEEPQLLVLMRFVWQHSRQEFDVSHRCPRAVGPDVELTLDRVRALFTFLLNKRKHGLSILLFKLASIQPTLRLMFTGPRFGLKVFPRTFSRVFVSYRQSFVGEFKFCSNGAVLVRDIFQTAFRTEPAVQYLASPMHPMPRLQPFIAHLAQRLMQRRKGFIAIHGNVVMADVRARQHVLPLRDGDECDALTRYLSIVGVCECLARLCNQLSGATVTQQPTRENPLLPLQMYVPPAKLTLVIENFSRLVASWSFDEGSPSYTSDMLMVLQDIIDKKVAAPPFPEAAASLFLKLLLLPMKQVTDVLSVCRYMDAGIDLCVTPPAGIVFATDGDTDCFAIARSPAPPGQARWFGVVFLIRGPSNEHHVVPLQLSVTQDRMSLWPPNKHKTHPRRLLAFKQAAAFIQANAEKWRTVTMLFALCEHLYSNHDDLSLFPTIAQLQQLPSK
Length1642
PositionTail
OrganismSalpingoeca rosetta (strain ATCC 50818 / BSB-021)
KingdomChoanoflagellida
LineageEukaryota> Choanoflagellata> Craspedida> Salpingoecidae> Salpingoeca.
Aromaticity0.06
Grand average of hydropathy-0.103
Instability index52.29
Isoelectric point7.31
Molecular weight176971.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27039
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.83|      10|      16|    1322|    1331|       1
---------------------------------------------------------------------------
 1322- 1331 (17.69/ 9.16)	RTEPAVQYLA
 1339- 1348 (18.14/ 9.59)	RLQPFIAHLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.22|      24|      25|     323|     346|       2
---------------------------------------------------------------------------
  288-  312 (25.38/10.39)	..SSSPSSLKLSFWpefKRLVSRVESY
  323-  346 (41.14/21.92)	PPSSSSSSSSSSSW...LALVKAAAGA
  349-  372 (42.70/23.06)	PPGSTQPASQSSSR...GGGVEGWASA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.19|      12|      17|     786|     798|       3
---------------------------------------------------------------------------
  786-  798 (17.68/12.00)	SArAGSTSSPASG
  826-  837 (19.51/ 8.16)	TS.AGATHSSLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.47|      13|      17|     141|     154|       4
---------------------------------------------------------------------------
  141-  154 (21.11/16.38)	RALSWLHMQiRGRL
  161-  173 (22.36/12.21)	RGLSAVTIG.KGRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.02|      40|     116|     881|     923|       6
---------------------------------------------------------------------------
  881-  923 (70.59/47.21)	CQAAemeGALRVDTVMDI.LVDKHQHQHQHQQQQQGLA.DARFNW
  999- 1040 (66.43/37.26)	CAAS...GICRWQIAMDTsRLPSWLHQRQTVADNDSLAlKGRFDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.94|      14|      17|    1055|    1070|       7
---------------------------------------------------------------------------
 1055- 1070 (24.29/19.79)	CLdaLQRPWYSHMKFL
 1074- 1087 (26.65/14.76)	CM..LRDESLPHHKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.71|      13|      25|     956|     968|       8
---------------------------------------------------------------------------
  939-  950 (15.09/ 6.19)	.RFAMLLSCVSRQ
  956-  968 (22.50/13.81)	LRHSPLISLSDAQ
  984-  996 (21.12/12.39)	LATSPLVPLKSAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     308.76|     103|     588|     509|     636|       9
---------------------------------------------------------------------------
  509-  636 (155.90/110.16)	PTA.ATTTTATTTAAAAATqplslwRMGTRSEGRSGGvmDTRWHDVADDDGGAGNNDDDVADDamcvnvtfpirveatAASAAAAAMKS.....GDAEDSG.PSLGTTSSPSSPDVTALEtlTP..........TEERLSLRV...CP
 1105- 1227 (152.86/70.72)	PNAdKVVPTSSSTAAAAGA......TAGAGAGGGGGG..DTNVNSSSAVLGDALTTTTSVAID...............AATAAASATSGhdgvlGNITTAGlPTSGSAVSPAPPSPPAEE..EPqllvlmrfvwQHSRQEFDVshrCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.25|      21|      32|     724|     744|      10
---------------------------------------------------------------------------
  724-  744 (36.75/25.27)	PGH.ALLLSVSASLSMRVRMLA
  758-  779 (34.50/23.14)	PGHtATSPHMSSSSSVATAMLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.29|      70|     196|       5|      74|      11
---------------------------------------------------------------------------
    5-   74 (118.35/71.67)	PLRLL.VDMIVQRAYK.DL....ADMTETV.APARQRQQELMR.YLHEAR.QRFMRLLVILRWLSKSGQADNVATLVQA
  195-  273 (95.94/56.68)	PWRLLtVDVFVRDEWRlDAhaapASCERLVtSPHIERLRRLLKgILDTTRdQPLSRCCAAIHTFCLSLQLNTMAAQAEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.90|      12|      19|     400|     411|      13
---------------------------------------------------------------------------
  400-  411 (22.25/13.03)	NHANRTSDDSGD
  422-  433 (23.65/14.36)	NEAMPPVYDSFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.54|      18|      19|    1261|    1278|      14
---------------------------------------------------------------------------
 1261- 1278 (31.67/20.12)	FKLASIQPTLRLMFTGPR
 1279- 1296 (31.87/20.30)	FGLKVFPRTFSRVFVSYR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27039 with Med14 domain of Kingdom Choanoflagellida
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