<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27038

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSFSPQNYESSSSTTKSTSPAHTAAQSANLSSPPSSVAMQPHSVSQSTVTTSTSCPTPASSTSGLARDGSDGSGAIAASFADGKIPFETLGSDTKHFAHDHHNNEKSVDTQKPSSNDSNDHDPMDVDLKEGAGLSEEPSLESLQRDVGEAIGLCKSTYTTTLPVPKFDIISLYGLGPIAASVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKQEPGAPGGLRNLMMWPDEEWYNQKVAGKEITIAEPDTAFYKQQLRAMKMEPGITPRNEYWEDVLGHEKSSKNAAEQLPKKLVSSSFKNTPQSNGTPAAQASSATVAPDPGRPKRAGRKRSYHDSSFVGYGEGFPDDDDLEGSLYSNDDDGGSVGKKKRKKMVRSSCMFIALPILGTLSFILFDITYLPYYSKNMQQEVLRLSSEAAATALECSALVPDDNRPRISNCDPWSIIAKLPFQTMNPCIRMD
Length465
PositionHead
OrganismTrichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.06
Grand average of hydropathy-0.618
Instability index47.18
Isoelectric point6.05
Molecular weight50168.40
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27038
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.79|      69|     101|       4|      81|       1
---------------------------------------------------------------------------
    8-   81 (112.19/73.43)	YESSSSTTKSTSPAHTAA.........................QSANLSSPPSSVAMQ...PHSVSQSTVTTSTSCPTPASSTSGLArdgsdGSGAIAASFA
   87-  183 (102.60/50.37)	FETLGSDTKHFAHDHHNNeksvdtqkpssndsndhdpmdvdlkEGAGLSEEPSLESLQrdvGEAIGLCKSTYTTTLPVPKFDIISLY.....GLGPIAASVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.31|      22|     107|     309|     330|       2
---------------------------------------------------------------------------
  286-  308 (26.77/13.52)	SSKNAAEQLPKKLVSSSfKNTPQ
  309-  330 (35.57/20.41)	SNGTPAAQASSATVAPD.PGRPK
  331-  351 (29.97/16.02)	RAGRKRSYHDSSFVGYG.EGFP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.30|      13|      17|     233|     245|       3
---------------------------------------------------------------------------
  233-  245 (26.04/18.56)	PDEEWYNQKV.AGK
  252-  265 (20.26/12.90)	PDTAFYKQQLrAMK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27038 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSFSPQNYESSSSTTKSTSPAHTAAQSANLSSPPSSVAMQPHSVSQSTVTTSTSCPTPASSTSGLARDGSDGSGAIAA
2) PRNEYWEDVLGHEKSSKNAAEQLPKKLVSSSFKNTPQSNGTPAAQASSATVAPDPGRPKRAGRKRSY
3) TLGSDTKHFAHDHHNNEKSVDTQKPSSNDSNDHDPMDVDLKEGAGLSEEPSLESL
1
272
89
78
338
143










Molecular Recognition Features






MoRF SequenceStartStop




NANANA