<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27037

Description CMGC/CDK/CDK8 protein kinase
SequenceMASRSTTKGIHRTVQVAFDDSANQMKSPGFGYTSKVRIREKYHIVGFISSGTYGRVYKAVGKNGQKGEFAIKKFKPDKEGETIQYTGLSQSAVREIALCTELNHPNVVRLVEIILEDRCIFMVFEYTEHDLLQIIHHHTQPQRHAIPAPMVKSILFQLLNGLLYLHSNWVLHRDFKPANILVTSCGAVRIGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLLGSRHYTPAVDLWAVGCIFAELLSLRPIFKGEEAKMDSKKNVPFQRNQMLKIMEILGMPLKQNWPGLASMPEYGQLQAFALGPGTSHIQKLSSLEPWYNACLKNGSYSPSSTAGTPGKEGFDLLSRLLEYNPAKRITAKEALEHPYFSTGSPITANCFEGFEGKYPNRRVSQDDNDIRTSSLPGTKRSGLPDDSLTSRAAKRVREM
Length430
PositionKinase
OrganismTrichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.09
Grand average of hydropathy-0.302
Instability index40.49
Isoelectric point9.38
Molecular weight48194.91
Publications
PubMed=22951933

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.42|      48|     262|      57|     105|       1
---------------------------------------------------------------------------
   57-  105 (77.85/62.72)	YKAVGKNGQKGEFAIKKfKPDKEGETIQYTGLSQSAVREIALCTELNHP
  322-  369 (83.57/61.85)	YNACLKNGSYSPSSTAG.TPGKEGFDLLSRLLEYNPAKRITAKEALEHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.03|      38|      91|     117|     159|       2
---------------------------------------------------------------------------
  117-  159 (56.29/55.93)	DRCIFMVFeYTEHDLLQIIHHHTqPqrhAIPAPMVKSILFQLL
  210-  247 (68.75/47.17)	DKVVVTIW.YRAPELLLGSRHYT.P...AVDLWAVGCIFAELL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27037 with CDK8 domain of Kingdom Fungi
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