<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27030

Description Uncharacterized protein
SequenceMKSGIVGCCDLLHNLVLNQKIMTCFRQAVEVARSHWGNNLRIELLHRTLVIQYWTNRPGPKSWIEIGTRRNKSQRGGRAYQPDIPRLYVRWIRDNKEVSVESTHFENKIISVETILRRTISRHIHDIFFEVYTKLTASKLYGQGVLFLGLNTSATEPGNCYLDIQLTRRKTMRLAIEPVGGIVALRTVPLSLSRHDVEPDPNKALSVGIYERICRLRCLVAMEEAESHGRVVGWKLIAPANVDMQSLRKVLPVNEIRNISLFQHGDWDPNWLVAFTSSIERDDWWVIQLRDKAPSATESQTRCPGDGRLIQLQQAHAITGQCGYASNKHRYRSFAKLANSISGMVVAHSNADCLNKLKLCHFPKIEDQVLGVDNEVLDTNVCYKASDLPHQLRVASPLSNKSKTIIKDTICLSYKGINHRTREAIVVATGFFAVPVSHLGMAILASDSNLSFKPRSRKFAIRFFTRIGVPIIEQLFSWLQRLTNTIFALGFIHRKKFVVTSISSSKISFTYPSSNGSLRASIFFQYIDTRPPLLLPDNQQSKTKGDKRPLARLRMSLDLHGKNPHRRIMESLTAILNDPSAGLGFTLELLTLTLPFLEAVETILAESRDRSRAVVRIAARSAKMYHISYPYLQYRFHLTMKQRRQRICWLLRNGTIPSVRMSQVALESELTNKILKVNGDGWRGLGDGAMAEADNPVSLIMVLDNIIKTHVAQQRTQAAANGAGRVMMLDGNQSNSVPASLSNSSGTSQPAMTATSTTGVVAPNSESDVSKQANNGSVITID
Length782
PositionTail
OrganismTrichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index44.98
Isoelectric point9.83
Molecular weight87622.98
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27030
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.33|      16|      26|     328|     353|       1
---------------------------------------------------------------------------
  328-  343 (26.98/32.11)	KHRYRSFAKLANSISG
  356-  371 (28.35/10.21)	KLKLCHFPKIEDQVLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.43|      13|      16|     104|     119|       7
---------------------------------------------------------------------------
  104-  116 (21.17/19.62)	HFENKIISVETIL
  123-  135 (23.27/11.07)	HIHDIFFEVYTKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.22|      21|      40|     678|     699|       8
---------------------------------------------------------------------------
  678-  699 (35.28/26.12)	NGDGWRGLGDGAMAEAdNPVSL
  721-  741 (37.94/23.17)	NGAGRVMMLDGNQSNS.VPASL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27030 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAGRVMMLDGNQSNSVPASLSNSSGTSQPAMTATSTTGVVAPNSESDVSKQANNGSV
722
778










Molecular Recognition Features






MoRF SequenceStartStop




NANANA