<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27020

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDDPSAHGVWRTVGTVNGDNAASDNGTLQHTDTNSHANGQSNGIKSQSDDMLTAPELPPPEITHITQGFFPLAKGINRVVVQCWNDLLHLLSELGDAHPNHQGGSSSSNASSVKKSQILEFAQAKRAEFIKLLVLSQWGRQAVDVGRLIDLQFFIRQRYDLYNHAIFLAGNIKRDLFKAQMGNPDLETALEALSTGAVSALPAEVSIESTHFEDKIISVETILRRTISRHIHDIFFEVYTKLTASKLYGQGVLFLGLNTSATEPGNCYLDIQLTRRKTMRVTIEPVGGIVALRTVPLSLNRHDVEPDPNKALSVGTYERICRLRCLVAMEEAESHGRVVGWKLIAPANVDMQSLRKVLPVNEIRNISLFQHGDWDPNWLVAFTSSIERDDWWVIQLRDKASATESQPQCPSDGRLIQLQQAHAITGQCGYASNKHRYRSFAKLANSISGMVVAHSNADCLSKLKLCHFPKVEYQVLGVDNEVPATSVCYKASDLPHQLRVASPLSSKGKAIIKDTIYLSYKGINHRTREAIVVATGFFAVPVSHLGMDILASDSNLSFKPRSRKFAIRFLTRTGVPIIEQLFSWLQRLTNTVLALGFIYRKKFAVTSISSSKISFTYPSSSGSLRASISFQYIDTPPPLLLPDNQQAKIKGDKRPLTRLRMSLDLHGKNPHRRIMESLTAILNDPSAGLGFTLELLTLTLPLLEAVETILAESRDRSRAVVRIAARSAKMYHISYPFLQYRFHLTMKQRRQRISWLLRNGTIPSVRMSQVALESELTNKILKVNGDGWRGLGDGAMAEADNPVSLIMVLDNIIKTHVAQQRTQAAANGAGKVMKVDGNQSNAAAASLSNSSSTSQPAAVTATSTTGVLAPNSESDISKQANNGSVITID
Length889
PositionTail
OrganismTrichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.07
Grand average of hydropathy-0.187
Instability index40.01
Isoelectric point9.33
Molecular weight97888.66
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27020
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.33|      72|     466|     170|     314|       1
---------------------------------------------------------------------------
  170-  255 (95.45/178.50)	GNiKRDLFKAQMG......NPDlETALEALStgAVSALPAE...VSIESTHFE.dkiiSVETIL..RRTISRHIhdiffeVYTKLTASKLYGQGVLFL
  651-  738 (100.88/65.75)	GD.KRPLTRLRMSldlhgkNPH.RRIMESLT..AILNDPSAglgFTLELLTLTlplleAVETILaeSRDRSRAV......VRIAARSAKMYHISYPFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.29|      24|     368|      64|      87|       4
---------------------------------------------------------------------------
   64-   87 (45.87/35.33)	HITQGFFPLAKGINRVVV.....QCWNDL
  435-  463 (36.42/26.42)	HRYRSFAKLANSISGMVVahsnaDCLSKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.20|      14|     765|      10|      23|       5
---------------------------------------------------------------------------
   10-   23 (27.73/18.84)	WRTVGT...VNGDNAAS
  788-  804 (21.47/12.90)	WRGLGDgamAEADNPVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27020 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNQSNAAAASLSNSSSTSQPAAVTATSTTGVLAPNSESDI
2) MDDPSAHGVWRTVGTVNGDNAASDNGTLQHTDTNSHANGQSNGIKSQSDDMLTAPELP
837
1
876
58










Molecular Recognition Features






MoRF SequenceStartStop




NANANA