<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27019

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMASLLNRPSGASRPEWQKFLRQCLLQRISTDEFHNLAKVMLRRHPISHKDLFDVVLESRAVTNFDWDPLIPDYVDAVQKLTQVELFNILPTLLAHSSIKSDVRRWKEQNQAQNQDTDQKVDGKGSTKPAGSKGPVTLLTDYGIIQNVITAVTTGHAPKIALEFMDTCSAIVDWILALVSWNAHLGSEKGEGSGTQLLATPDVVSIFIAVGFLFGALAGTEVGANALSFQHAGTFKHQRMKLARALTAYSPICAEISIPLRNRLDQLQKEFNLFLKGEKSNQDHVIEDTAVSTLEFESRVVDIPPVSSRAGLYIYVNSLLVGRPLIDDNLLINYLNNRYGGNHMALVEELITASFDVLSNGMYRNEPQQSMFLFRAFLVNKLPPFLSDLAGSVVEPIPVELCITRALARVDPNTFPSFSEIFSTHGNSVLSDVRQEFLFSCALHKLIPESSIERLLGENPMQTLPNEGRFVKHDLVAQINNNHERAEQLLNGIESMDGNARAIVEAIAEVMHNMCLRKDTMTLKSLCNSLSRRPQTLDIMLLFKSPQAILQPLCALLDSWKWEEDQGESQPVYDEFGSVLLLVLAFRYKYDLSYQDLGVFNPDSFMCRLLEKGSSSQKLEDLTEKQQQNLGAWITALFIAEGISDESMSSCSPQEFYLLVATLFCQSLSACEAGKLEFDTLKGGFEYLLEPFLLPSLVMALSWMGKHIWKSGTDITTTLKLLASLVKPTSISGEAQEIHRTVLSITARELADELRTAKARHPLRTDIEPILQALEPYQSFQRTGTSTRSELEGWRSSSAPGGMVTGIRNTFSSLVLWSTDPEISMTPPSYTHRQLLAGLKHLGSVRVLAGILEELKLQSETGSGDLAIDIAATLICAPMRECFSLEQAAYQSVGGSLKDSLPRRQMLNLRDALNLQRESLSKVIEYEPHRAELINRLARRVDTLTSIPQIPQGVENIDVGNIMANMDLTGVEEDRQMQIDVAQQAEQQDQQHQNLTAAGTDATPGTLDAILDVATAEGVTAPPTGTEVTMAQPDMDASIFDDMLNPTDMGVGNPEFIDLDMEGMF
Length1064
PositionTail
OrganismTrichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.07
Grand average of hydropathy-0.129
Instability index43.21
Isoelectric point5.00
Molecular weight117917.14
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27019
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.09|      14|      27|     692|     705|       1
---------------------------------------------------------------------------
  692-  705 (26.52/19.66)	LLPSLVMALSWMGK
  720-  733 (23.57/16.54)	LLASLVKPTSISGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.18|      28|      30|     993|    1021|       2
---------------------------------------------------------------------------
  993- 1021 (42.12/26.56)	NLTAAGTDATPGTLDAILDvATAEGVTAP
 1026- 1053 (52.06/29.34)	EVTMAQPDMDASIFDDMLN.PTDMGVGNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.98|      22|      28|     552|     579|       3
---------------------------------------------------------------------------
  552-  575 (38.22/41.41)	LCALLDSWKWE...EDQGESQPvyDEF
  580-  604 (34.76/18.48)	LLVLAFRYKYDlsyQDLGVFNP..DSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.11|      27|      33|     452|     481|       6
---------------------------------------------------------------------------
  452-  481 (36.83/32.83)	ERLLgeNPMQTLPNEGRFVKhDLVAQINNN
  486-  512 (44.27/26.68)	EQLL..NGIESMDGNARAIV.EAIAEVMHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.55|      11|      21|     645|     655|       7
---------------------------------------------------------------------------
  645-  655 (22.00/13.36)	ESMSSCSPQ..EF
  665-  677 (15.55/ 7.32)	QSLSACEAGklEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.45|      27|      29|     785|     811|       8
---------------------------------------------------------------------------
  785-  811 (44.75/24.58)	STRSELEGWRSSSAPGGMVTGIRNTFS
  817-  843 (42.47/22.98)	STDPEISMTPPSYTHRQLLAGLKHLGS
  849-  873 (29.23/13.69)	GILEELK.LQSETGSGDLAIDIAATL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.80|      22|     314|      24|      45|       9
---------------------------------------------------------------------------
   24-   45 (38.38/28.45)	LLQRISTDEFHNLAKVMLRRHP
  345-  366 (37.42/27.55)	LVEELITASFDVLSNGMYRNEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.48|      14|      21|     943|     958|      11
---------------------------------------------------------------------------
  943-  958 (20.09/16.63)	LTSIPQIPQgvENIDV
  967-  980 (24.39/13.22)	LTGVEEDRQ..MQIDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27019 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDRQMQIDVAQQAEQQDQQHQNLTAAGTDATP
2) TLDAILDVATAEGVTAPPTGTEVTMAQPDMDASIFDDMLNPTDMGVGNPEFID
972
1005
1003
1057










Molecular Recognition Features






MoRF SequenceStartStop




NANANA