<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27010

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEETLDDLFGDSGGLDLSLSAPVPPKALPARIDELRILGCCQKIAWSRTGAIAYIAPDGSKAFLRNLNCSPEDGKWSLSDGDHEHPIAEAQTGHTLVHLAWNEPGADLAVVDCCGRISIIGMSIGLNVLIQSRPPALDPDDDGNQPVGLMWLALNRSVHTFSHAGRASGRWAYVRYPRRPMGPFHPLHKLALFVVTRSGKLKLLYQNQESKWGDMVIELQNTGYTDDVLTHASMTPVDGGGIMIVTYSARNELRLYRAMLKWEGTPVDSNTQRPNNSIAVPSVQLAHIEVEVPNVVPSPSTYVIGNEDNITNNANGLFALTHLQVVACPVDAPGGQTAPMILAVFSCPLHNVHGRSHLQHPSVIARWELRSVNQNLHKSFDSIVSKQPRNPLLPSTELNRQADTYFDRHIVSIDYMETGNIFAITTDDGNIAFYDAKGFTPLSGVEDFETVTSLPQSGFTFPAAISPSVHISFSPSGCIAASLDEKSHVQMRVMEHSFGHEQDGLFNDGKFMSALAALTMAYCRACSSDSNNDDILMIVIQQLNQDSHKKFIDEVYRALSMNVTVEQDKLMNNPYILKCFSMQAALGFKNRLERRSLAAAVPWLTLQLRQISILLTYILHFNKAGSDVECYDPETLRITLGNVKWALDLAKYIVDDLFEISDNLNSHSSSQDSGSSSGKLYESLSTILIISSIPRSFLRYICRGLRGLTSGFRNAMNLSNESYQIYSQIVTVITESALKVDVYEKLLASVESDVKHAYQNAGFNNADRAAPERDLLINGSIPPVLQPAVTAILTKTVPMIRNEANPMYLFLQDYSWLGVGDDKRADLFRHKYEIDILRKVLIPLDESRGAVRPSRRCVRCCAISEEIPPKSMAAVKMLMRTAVLRACTCGGMWSMSNASNLRGSTTLPGWRQPG
Length914
PositionTail
OrganismTrichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.07
Grand average of hydropathy-0.145
Instability index50.39
Isoelectric point6.12
Molecular weight100923.97
Publications
PubMed=22951933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27010
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.50|      21|      49|     186|     206|       1
---------------------------------------------------------------------------
  186-  206 (35.47/24.23)	PLHKLALFVVTRSGKLKL.LYQ
  236-  257 (33.03/22.06)	PVDGGGIMIVTYSARNELrLYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.74|      22|     647|      97|     139|       2
---------------------------------------------------------------------------
   97-  118 (40.86/53.73)	VHLAWNEPGADLAVVDCCGRIS
  147-  168 (38.88/12.61)	VGLMWLALNRSVHTFSHAGRAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.85|      28|     845|      23|      51|       7
---------------------------------------------------------------------------
   23-   51 (48.86/33.38)	VPPKALPARIDELR..IL.GC.CQKIaWSRTGA
  867-  898 (40.99/23.27)	IPPKSMAAVKMLMRtaVLrACtCGGM.WSMSNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.44|      18|     102|     261|     278|       8
---------------------------------------------------------------------------
  261-  278 (33.93/25.11)	KWEGTPVDSNTQRPNNSI
  366-  383 (32.51/23.71)	RWELRSVNQNLHKSFDSI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27010 with Med16 domain of Kingdom Fungi
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