<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27008

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPIGAETNGRVFDELSTCHWKVYGVDSNGSGLGTSGSSVNQLFKKIQICALALREAGCLTCPSSDGTGIWVFSLDAEFSRLKSFASNQSKDSEDLVVGQVPIYEYCGGTTSIAELSQKLLSKSSENTRNSSLAETLSSRNKLEIPASLELTHSSLYASFISSIAWSLSLHLTKHHGAIPLGKRTFFTAADSDMSSGSTSTSVISTLDIELSQSGKVIISLRSRSQPGITQLSEGPGVSSISELRLHDDIWLAPAGTIARYIGIGGSEYALGTGNSYHSNNIHGSRNGFSSEGQDPWKLAVCSWLERTGVPIEISDNMRWVQVEVVTRHQRLGQGKATGTRRIYWPAQLCFKKARFPTSSPIQGAETLSRDSLGPLQYARQWLKCSVPRDEVLSRNAPSDVAQHPEQHPQSETLASPDGIDVPNTTESMARALVYPDFHPATVYPTPPGGALGFGQLASDHSGGQYPLELSHIPREDPDTNITESLNPNTRSLLEETSPGLGAGTGMYDTADDDLFEEMDDNFDNKGITEADFNFFDEPGLSDTNLDVDSGNPSHSFVIPDHPTAESKPDLEMSESLASLEPAPPTKPHGMETPMLDNAVEEGANQGQSEIKSSQPTARAADTDRDTERPISPPLSPSGVKRILFSSPRGSSEKSKSTTISATKLPVEASNQSGQYKGRYDAISFQHELDFSDRKYGIDGRFWFLPDHKTFNHNTDSHTTKIPMVNDLLAPVYKLGQQAYHKINERLDNADSERCSSSTSSTSSVSGDHYEQAGFNKMRPVDPIDNRPSLKSYASISDIGPSQQMKDATGAIVSLRPPHMHIRRGNCSLEVLPTAISFWETFGLEPLKGKKDIISYCLHPVSMQESANAFLDRLGLTYSGANLGTFARHGSAKGLVPWSLSQDKLDYTSIMRKLQHICESLGTALSNLSMNNKTVVVCIVNPFKIGAAMVDICVAFLRLFRKYVEEADKRSVRRPNELVLQIVPSEFITGDDSLVIPTQNDYLRLALEVYSRCPPQDPISDMFAGAPAFALATSVPKMIPFRLTAEEGSPMDAGQACHVAYSVSQDQRWVTAAWCDNLGLRQLTLSYSLRQDVSHTCRPLSEVREDIWQVMVDMTGMSRCRWRVVLAKDEPMDAEEITAWTNLAARHNQHHSGLVDLILLTVNTEPNLHLKLPPPPPQLNALYQSGNASTPVSTPKPSISSPDPSTSAPTPPNISNTPNFSSESSQPQAQSHFQVHPTQISVETNTETLLVDKSDDSWALVLSQRLNNSHSFTNYKPALANGYLIHRSGTSDTDWKASLMVNLIHLQSRIPPSIVLKDLLGQEDLPVLGEIMASLGTFLLPLKDRSY
Length1348
PositionKinase
OrganismTrichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.07
Grand average of hydropathy-0.397
Instability index47.24
Isoelectric point5.47
Molecular weight147424.36
Publications
PubMed=22951933

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27008
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.92|      35|      85|     352|     392|       1
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  352-  392 (52.18/47.26)	FKKAR.FPTssPIQGA...ETLSRDSLGPlQYArqwLKCS.VPRDE
  439-  478 (55.74/31.02)	FHPATvYPT..PPGGAlgfGQLASDHSGG.QYP...LELShIPRED
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     428.78|     128|     149|     487|     634|       2
---------------------------------------------------------------------------
  192-  280 (88.97/46.10)	DSD.MSSGSTSTS.................VISTldieLSQSGkviislRS...RSQP.GitqLSEGPGVSSISELRL....HDDIWLAPAGTIARY.....IGIGGSEYALGTGNSYHS.................................................
  487-  600 (178.55/104.63)	......................................LNPNT......RSLLeETSP.G...LGAGTGMYDTADDDL.FEEMDDNFDNKGITEADFNFFDEPGLSDTNLDVDSGNPSHSFVIPDHPTAESKPD.....LEM.SESLASLEPAPPTKPHGMeTPMLDNA
  601-  751 (161.26/119.06)	VEEgANQGQSEIKssqptaraadtdrdterPISP...pLSPSG....vkRILF..SSPrG...SSEKSKSTTISATKLpVEASNQSGQYKGRYDA.ISFQHELDFSDRKYGID....GRFWFLPDHKTFNHNTDshttkIPMvNDLLAPVYKLGQQAYHKI.NERLDNA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     323.12|      91|     156|     853|     953|       3
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  287-  319 (34.86/14.05)	..........................................RNGfSS..EGQ...DPW.....KLAV..........C..........SWLERTGV.....PIE.....ISDNM...
  853-  953 (151.47/110.76)	DIISYC..LHPVS.MQESANAFldrlGLTYSGANLGTF...ARHG.SA..KGL...VPWSLSQDKLDYTSIMrklqhiCESLGTALSNLSMNNKTVVVCIVNPFK.....IGAAMVDI
 1009- 1115 (136.79/81.67)	EVYSRCppQDPISdMFAGAPAF....ALATSVPKMIPFrltAEEG.SPmdAGQachVAYSVSQDQRWVTAAW......CDNLGLRQLTLSYSLRQDVSHTCRPLSevredIWQVMVDM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.56|      65|     134|    1123|    1193|       4
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 1123- 1193 (102.49/78.77)	WRVVLAKdEPMDAEEITAW.TNLAARHNQHHSGLVDL...ILLTVNTepnLHLK.LPPPPPQLNALYqsGNASTPV
 1259- 1328 (100.07/59.61)	WALVLSQ.RLNNSHSFTNYkPALANGYLIHRSGTSDTdwkASLMVNL...IHLQsRIPPSIVLKDLL..GQEDLPV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.43|      35|     275|     117|     151|       7
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  117-  151 (53.60/27.45)	LSQKLLSKSSENTRNSSLAETLSSRNKLEIPASLE
  394-  428 (60.83/32.11)	LSRNAPSDVAQHPEQHPQSETLASPDGIDVPNTTE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27008 with Med13 domain of Kingdom Fungi
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