Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MNVTNARHRDSAGAEEAMENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPPGGGPGPAPPSTAATAAPGSDKSAAGCGPFYLMRELPGSTELTGSTNLITHYNLEHSYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR |
Length | 261 |
Position | Head |
Organism | Sus scrofa (Pig) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -1.027 |
Instability index | 62.81 |
Isoelectric point | 9.78 |
Molecular weight | 28078.62 |
Publications | PubMed=30723633 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro transcription factor binding GO:0008134 IBA:GO_Central |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP26989 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 79.91| 16| 17| 207| 222| 1 --------------------------------------------------------------------------- 187- 200 (25.73/11.14) P..PKKKNKHKHKQSR 207- 222 (27.40/12.31) PETPSDSDHKKKKKKK 226- 241 (26.77/11.87) PERKRKKKEKKKKKNR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 67.75| 20| 115| 127| 147| 2 --------------------------------------------------------------------------- 71- 95 (28.98/13.89) GS.DKSAagcgpFYLM....RELPGSTE......LT 137- 167 (17.97/10.79) GShDNSS.....LRSLiekpPILGGSFNpitgtmLA 168- 177 (20.80/ 8.10) G...........FR.L....HTGP..........LP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 68.84| 17| 26| 26| 42| 4 --------------------------------------------------------------------------- 26- 42 (35.29/13.18) GAQADPPPPPTALGFGP 54- 70 (33.55/12.19) GGGPGPAPPSTAATAAP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AMENFTALFGA 2) DSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDH | 17 212 | 27 246 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab