<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26988

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNTKDNYWLVPARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQTTDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPGLLAAHSPHVMIGPNNASIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADENYPKDHDVKMEEQTLMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTEPGVGDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARTINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNSNVNSLKNDDFTMRGLRRDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSADASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRMDRKVVKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSGIYRVPPNYSPISSQMMHHPQSALWGYNLMGQPQQPGFFLQNQSLPPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMVTPLLSFLLLSFLFFF
Length1974
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.07
Grand average of hydropathy-0.344
Instability index51.86
Isoelectric point6.49
Molecular weight221108.02
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26988
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.32|      19|     202|      21|      45|       1
---------------------------------------------------------------------------
   21-   45 (27.17/31.12)	PPDVyPQDPKQKEdeltaVNVKQGF
  220-  238 (38.16/22.85)	PPDV.EQAMRQWE.....YNEKLAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     458.94|     126|     909|     703|     835|       2
---------------------------------------------------------------------------
  703-  835 (195.51/137.68)	NANPSLGRRMSVNGEKLLKREKPRELI..FPSNYDLLRHLQyathFPIPLDESSSHECNQRTI.LLYGVG...KERDEARHQ.LKKITKDILKILNKKSTTePGVGDEGQKARKNKQEAFptLETVFTKLQLLSYFDQHQ
 1463- 1533 (72.91/38.48)	......GRVLKAAGEEL...EKGQHLG..SSSKKERDRQKQ..........KSMSLLSQQPFLsLVLTCL...KGQDEQREGlLTSLQNQVNQIL.............................................
 1622- 1744 (190.52/115.61)	NASPGGSEENKRAYMNLVKKLK.KELGdkRSESIDKVRQL.....LPLPKQTCDVITCEPMGS.LIDTKGnkiAGFD....S.IDK..KQGLQVSTKQKVS.PWDLFEGQKNPAPLSWAW..FGTVRMDRKVVKYEEQHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.08|      61|    1093|     634|     698|       6
---------------------------------------------------------------------------
  634-  698 (93.55/83.53)	RPRS......PAGENADENYPKDhDVKMEEQTLMAHMGiDSGTTNIfDEVDKS...DFKTDFGSEFPIFsPMPG
 1755- 1824 (93.53/63.60)	KPRSyyleplPLPPEEEEEEPTS.PISQEPERKSAELS.DQGKTAT.DEEKKTkgrKRKTKSSSRVDEY.PQSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.56|      28|    1093|     428|     455|       7
---------------------------------------------------------------------------
  428-  455 (50.62/28.71)	EQQIKQR...GRAVEVRWS.....FDKCQESTAGVT
 1542- 1577 (38.94/20.58)	QDDIKARqmmHEALQLRLNlvggmFDTVQRSTQWTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.90|      16|      27|     910|     935|       8
---------------------------------------------------------------------------
  910-  935 (10.06/33.95)	YtTGLCvcivAVLRryHsclILNPEQ
  940-  955 (29.84/16.86)	F.EGLC....GVVK..H...VVNPSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.36|      13|     748|     373|     387|       9
---------------------------------------------------------------------------
  373-  387 (25.03/21.58)	LCCPSALVWNYstND
 1091- 1103 (30.33/19.04)	LCCSSNHVWGF..ND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.56|      56|    1093|     308|     369|      10
---------------------------------------------------------------------------
  308-  369 (96.07/63.82)	DSPGLLAAHSPHVMIGPNNASIGAPSPGppgpgmSPVQLAFSDFLSCAQH......GPLVYGLSCMLQ
 1401- 1462 (88.49/46.41)	QSADLNNNSSNSGMGLFNPNGIGSADAS......STRQNGIKTFLSSSERrgvwlvAPLIARLPTSVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.37|      34|    1093|      87|     120|      11
---------------------------------------------------------------------------
   87-  120 (62.30/38.49)	QDTGKKKPQVNTK.DNYWLVPARSQSAIHSWFSDL
 1181- 1215 (53.07/31.68)	QATGKPFPGIRSScDRHLLAAAHNSIEVGAVFAVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.20|      53|     192|     840|     902|      12
---------------------------------------------------------------------------
  840-  902 (74.84/71.51)	ISNNVLEQItSFASGTSYHLPLAHhiqlifdlmEPALNINGLIDFAIQLLNELSVVEAELL..LK
 1035- 1089 (90.36/59.92)	LSDNAANRY.SFVCNTLMNVCMGH.........QDAGRINDIANFSSELTACCTVLSSEWLgvLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.11|      51|     750|     513|     571|      13
---------------------------------------------------------------------------
  513-  571 (82.86/74.02)	WAVSC..KRSGKHRAMAVAKLLE.KR.......QAEIEAERC.GESEVL.DEKESISSaslagsslPVFQN
 1254- 1316 (68.25/46.07)	WTASQnpKSCGKSISIETANLREyARyvlrticQQEWVGEHClKEPERLcTDKELILD........PVLSN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26988 with Med12 domain of Kingdom Metazoa
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