<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26981
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MEREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESEGGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTVLAGASGLQQVQMAGAPSQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR |
Length | 268 |
Position | Head |
Organism | Sus scrofa (Pig) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.566 |
Instability index | 46.04 |
Isoelectric point | 6.14 |
Molecular weight | 29120.59 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26981
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.06| 23| 27| 165| 191| 1
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165- 191 (33.84/25.64) GLRPNKQTFNPADTNALVAAvafgKGL
198- 220 (41.22/21.69) GSSGPGQPGQPGAGTVLAGA....SGL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.41| 19| 27| 67| 86| 2
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67- 86 (29.90/25.96) KTPLFRNQViIP..LVLSPDRD
96- 116 (30.51/21.01) RVPVFSHEV.VPdhLRTKPDPE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 73.42| 24| 29| 1| 29| 3
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1- 26 (32.46/27.13) MEREEKQLeaSLDALLSQVADLKNSL
33- 56 (40.96/19.51) LENEYDRL..TWPSVLDSFALLSGQL
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