<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26971

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISENKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGPTVGPLPHDVEVAIWQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDHNSSVIFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVRQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGSGRSGPYGVTVPPDLLHHPNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTSMIGTMTPLGAQSVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQAHQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2179
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.07
Grand average of hydropathy-0.515
Instability index57.39
Isoelectric point6.66
Molecular weight243307.86
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26971
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     183.31|      16|      16|    2052|    2067|       1
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 2052- 2065 (29.47/ 9.55)	....QQQ....QQQQQQQ......QQQQ
 2066- 2086 (29.27/ 9.43)	QQ.qQQQ....QQQQQQQ..yhirQQQQ
 2087- 2104 (33.51/11.80)	QQilRQQ....QQQQQQQ......QQQQ
 2105- 2120 (36.85/13.67)	QQ..QQQ....QQQQQQQ......QAHQ
 2121- 2140 (29.66/ 9.65)	QQ..QQQaappQPQPQSQ......PQFQ
 2141- 2162 (24.55/ 6.79)	RQ..GLQ....QTQQQQQtaalvrQLQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     514.29|     166|     232|     217|     447|       2
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  217-  413 (272.10/261.85)	GPTVGPLPHDVEV....AIWQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPTTPAPQ...............PPTSSTPSTPFSD..LLMCPQHRPLVFGlscilqtillccpsalvwH..YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSA
  451-  650 (242.19/224.49)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPSAPIFQdvllqfldtqapmltDPRSESERVEFFNlvLLFCELIRHDVFS..................HnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     754.90|     193|     230|    1626|    1820|       3
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 1450- 1624 (167.40/81.74)	......................EELEKGQHLGSSSRKERDrqkqksmsLLSQQPFLSLVLT...CLKGQDE..QREGLLTSlysqVRQIVNNWrdDqylddckpkqlMHEA..LKLRLNLVGGMFDTVQ..RSTQQT....TEWAVLLL..................EI..IISGTVDMQSNNelfTTVLDMlSVLINGTLAADMSSISQ......GSMEENKRAYMNLVKKLQKE.......................
 1627- 1820 (329.54/170.39)	ERQS..................DSLEKVRQLLPLPKQTRD........VITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVS....TKQKISPW..D...........LFEG..LKPSAPLSWGWFGTVRVDRRVARG....EEQQRLLLYHTHL....RPRPRAYYLEP..LPLPPEDEEPPA...PTLLEP.EKKAPEPPKTDKPGAAP......PSTEERKKKSTKGKKRSQPATKTeDYGMGSGRSGPYGVTVPPD
 1835- 2050 (257.96/131.84)	YRQGsiglytqnqplpaggprvDPYRPVR..LPMQK............LPTRPPYPGVLPTTMTGVMGLEPSYKTSVYR......QQQPAVP.................QGqrLRQQLQQSQGMLGQSSVHQMTPSSsyglQTSQGYTPYVSHVglqqHTGPAGTMVPPsySSQPYQSTHPST..nPTLVDP.TRHLQQRPSGYVHQQAPtyghglTST.QRFSHQTL.QQTSMIGTMT.PLGAQSVQAGVRSASILPE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.15|      38|     229|    1143|    1211|       4
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  993- 1030 (69.46/31.84)	LFSDF..CSKVKNTIY..CNVEPSESNMRWAPEFMIDTLENP
 1143- 1184 (55.69/71.56)	LLEDLirCAAIPSLLNaaCSEQDSEPGARLTCRILLHLFKTP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26971 with Med12 domain of Kingdom Metazoa
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