<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26968

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMNALQSLTSGPAAGATGIGIPSRGPGQPLGGMSGLGAMGQPMPLSGQPPPGTSGMAPHSMAVVSTAAPQTQLQLQQAALQQQQQQFQQQVALQQQQQQLQAQQSAMQQQFQVAVQQQQQQLQQQQQQQQHLIKLHHQNQQQMQQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPPMQQPQPPPSQALPQQLQQLHHPQHHQPPPQPQPPVAQNQPSQLPPQSQTQPLVSQAATLPGQMLYAQPQLKLVRAPMVVQQPQVQPQVQPQVQPQTAVPTAQASQIVGSGVQVSQSSLTMLSSPSPSQQVQTPQSMPPPPQPSPQPGPPSSQPNSNVSSGPTPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCARKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length654
PositionTail
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.03
Grand average of hydropathy-0.678
Instability index92.24
Isoelectric point9.29
Molecular weight71621.63
Publications
PubMed=30723633

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26968
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     208.58|      33|      34|      75|     108|       1
---------------------------------------------------------------------------
   67-   99 (46.77/ 8.90)	.APQTQLQLQ.QAALQQQQQQFQQQvALQQQQQQL
  100-  131 (51.07/ 8.42)	QAQQSAMQQQfQVAVQQQQQQLQQQ...QQQQQHL
  169-  197 (56.17/10.30)	QAQPPMQQ....PPMQQPQPPPSQ..ALPQQLQQL
  201-  230 (54.57/ 9.71)	QHHQPPPQPQ.PPVAQNQPSQLPP....QSQTQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.08|      18|      21|      14|      34|       4
---------------------------------------------------------------------------
   14-   33 (29.50/ 9.85)	GATGIGIPSrgPGQPLGGMS
   36-   53 (37.58/10.86)	GAMGQPMPL..SGQPPPGTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.12|      27|      27|     442|     468|       6
---------------------------------------------------------------------------
  442-  468 (46.29/22.45)	PSKRCPLKTLQKCEIALEKLKNDMAVP
  472-  498 (48.83/24.12)	PPPVPPTKQQYLCQPLLDAVLANIRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.57|      17|      61|     259|     278|       7
---------------------------------------------------------------------------
  259-  278 (26.30/15.95)	QPQVqpqVQPQVQPQTAVPT
  281-  297 (24.27/ 6.53)	ASQI...VGSGVQVSQSSLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.72|      11|      36|     329|     341|       8
---------------------------------------------------------------------------
  329-  341 (17.48/13.71)	SQPNSNVSsgPTP
  379-  389 (18.23/ 6.76)	VNPSSVMS..PAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26968 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNALQSLTSGPAAGATGIGIPSRGPGQPLGGMSGLGAMGQPMPLSGQPPPGTSGMAPHSMAVVSTAA
2) QQQQQQALQAQPPMQQPPMQQPQPPPSQALPQQLQQLHHPQHHQPPPQPQPPVAQNQPSQLPPQSQTQPLVSQAATLPGQMLYAQPQLKLVRAPMVVQQPQVQPQVQPQVQPQTAVPTAQASQIVGSGVQVSQSSLTMLSSPSPSQQVQTPQSMPPPPQPSPQPGPPSSQPNSNVSSGPTPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLS
1
161
67
406










Molecular Recognition Features






MoRF SequenceStartStop




NANANA